Opportunity Information: Apply for PAR 13 307
Apply for PAR 13 307
- The National Institutes of Health in the environment health income security and social services sector is offering a public funding opportunity titled "Developmental Pharmacology and Toxicology Role of Ontogeny (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Aug 7, 2013 and posted on Aug 5, 2013.
- Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts City or township governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses County governments Public and State controlled institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Developmental Pharmacology and Toxicology Role of Ontogeny (R03) funding opportunity (PAR-13-307) is a National Institutes of Health (NIH) discretionary grant program designed to support small, investigator-initiated projects that advance basic and translational research in developmental pharmacology and toxicology. The central goal is to improve understanding of how normal growth and maturation (ontogeny) shapes the way drugs are handled by the body and how drugs affect developing biological systems, with a clear focus on the full pediatric developmental spectrum from fetal life through adolescence. By emphasizing multidisciplinary approaches, the FOA aims to bring together expertise across fields such as pharmacology, toxicology, pediatrics, developmental biology, genetics/genomics, biochemistry, computational modeling, and clinical research to address questions that cannot be answered well within a single discipline.
A key scientific emphasis of the opportunity is on how developmental stage influences drug response and toxicity through changes in drug-metabolizing enzymes, drug transporters, receptors, and downstream signaling pathways. In practical terms, this includes research on how expression and function of these systems differ in fetuses, newborns, infants, children, and adolescents, and how those differences can alter absorption, distribution, metabolism, and excretion of therapeutics, as well as vulnerability to adverse effects. Projects responsive to the FOA would typically aim to clarify age-dependent mechanisms that drive variability in drug exposure or pharmacodynamic response, identify developmental windows of increased susceptibility to toxicity, or generate data that can help improve pediatric dosing, safety assessment, and therapeutic decision-making.
This FOA uses the NIH R03 mechanism, which is intended for smaller, focused studies such as pilot or feasibility work, proof-of-concept research, secondary analyses, method or assay development, or tightly scoped mechanistic investigations that can provide a foundation for larger future projects. The listed award ceiling is $50,000, and the announcement states there is no cost sharing or matching requirement. The funding instrument type is a grant, and the activity aligns with federal categories tied to environmental health and child health and human development (CFDA 93.113 and 93.865), reflecting the program’s dual focus on both therapeutic drug action and toxicological risk during development.
Eligibility is broad and includes many types of domestic and non-U.S. organizations. Eligible applicants include public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; state, county, city/township, and special district governments; independent school districts; public and Indian housing authorities; and Native American tribal governments and tribal organizations. The FOA also explicitly includes a wide range of mission-focused institutions and community-based entities such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, along with faith-based or community-based organizations. Foreign organizations and foreign institutions are eligible, non-U.S. components of U.S. organizations may apply, and foreign components are allowed consistent with NIH policy.
Key timeline details in the source data indicate the opportunity was posted on August 5, 2013 (created August 7, 2013), with an original and current closing date of September 7, 2016, and an archive date of October 8, 2016, meaning the announcement is no longer active for new submissions under that specific posting. The administering agency is NIH, and the full announcement was available through the NIH Grants Guide (link provided in the source). For technical issues accessing the announcement, the contact point listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: Developmental Pharmacology and Toxicology Role of Ontogeny (R03) (PAR-13-307)
What is the Developmental Pharmacology and Toxicology Role of Ontogeny (R03) opportunity (PAR-13-307)?
It is a National Institutes of Health (NIH) discretionary grant program that supports small, investigator-initiated projects advancing basic and translational research in developmental pharmacology and toxicology, with a focus on how ontogeny (normal growth and maturation) influences drug handling and drug effects in developing biological systems.
What is the main goal of this funding opportunity?
The central goal is to improve understanding of how developmental stage shapes pharmacology and toxicology, including how drugs are absorbed, distributed, metabolized, and excreted, and how drugs affect developing tissues and systems across the pediatric developmental spectrum.
Which populations or life stages are the focus of the research scope?
The FOA emphasizes the full pediatric developmental spectrum, specifically from fetal life through adolescence, including fetuses, newborns, infants, children, and adolescents.
What types of scientific questions does the FOA emphasize?
The FOA emphasizes questions about how developmental stage influences drug response and toxicity, including age-related changes in drug-metabolizing enzymes, drug transporters, receptors, and downstream signaling pathways, and how these changes affect variability in exposure, response, and adverse effects.
What kinds of projects are considered responsive to this FOA?
Projects that clarify age-dependent mechanisms driving variability in drug exposure or pharmacodynamic response, identify developmental windows of increased susceptibility to toxicity, or generate data that can improve pediatric dosing, safety assessment, and therapeutic decision-making are described as responsive in the provided information.
Does the FOA encourage multidisciplinary approaches?
Yes. The FOA explicitly emphasizes multidisciplinary work that brings together expertise across fields such as pharmacology, toxicology, pediatrics, developmental biology, genetics/genomics, biochemistry, computational modeling, and clinical research, especially for questions that are difficult to address within a single discipline.
What funding mechanism does this opportunity use?
This opportunity uses the NIH R03 mechanism, which is intended for smaller, focused studies.
What types of studies fit the R03 mechanism as described here?
Examples listed include pilot or feasibility studies, proof-of-concept research, secondary analyses, method or assay development, or tightly scoped mechanistic investigations that can serve as a foundation for larger future projects.
What is the award ceiling for this opportunity?
The listed award ceiling is $50,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
What is the funding instrument type?
The funding instrument type is a grant.
Which federal program categories (CFDA) are associated with this FOA?
The activity aligns with federal categories tied to environmental health and child health and human development, specifically CFDA 93.113 and 93.865.
Who administers this funding opportunity?
The administering agency is the National Institutes of Health (NIH).
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-U.S. organizations. Eligible applicants include public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; state, county, city/township, and special district governments; independent school districts; public and Indian housing authorities; and Native American tribal governments and tribal organizations.
Are community-based and mission-focused institutions included in eligibility?
Yes. The FOA explicitly includes institutions such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, along with faith-based or community-based organizations.
Are foreign organizations eligible to apply?
Yes. Foreign organizations and foreign institutions are eligible, non-U.S. components of U.S. organizations may apply, and foreign components are allowed consistent with NIH policy.
When was this opportunity posted, and what are the key dates?
The source data indicates it was posted on August 5, 2013 (created August 7, 2013). The original and current closing date is listed as September 7, 2016, and the archive date is October 8, 2016.
Is this funding opportunity still open for submissions?
No. Based on the provided dates (closing date September 7, 2016, archive date October 8, 2016), the announcement is no longer active for new submissions under that specific posting.
Where was the full announcement made available?
The full announcement was available through the NIH Grants Guide (a link was provided in the source information).
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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