Opportunity Information: Apply for PAR 07 416
Apply for PAR 07 416
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Developmental Pharmacology (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.279 Drug Abuse and Addiction Research Programs 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 24, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Public housing authorities/Indian housing authorities Independent school districts County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education Public and State controlled institutions of higher education State governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Developmental Pharmacology (R01) funding opportunity (PAR-07-416) is a National Institutes of Health (NIH) grant program designed to support investigator-initiated research that explains how normal growth and development shape the way drugs work in the body. The central idea is ontogeny, meaning the age-dependent changes that occur from fetal life through adolescence, and how those changes affect drug response. Projects are expected to take a multidisciplinary approach and can be either basic or translational, as long as they advance understanding of developmental differences in key biological systems that determine drug disposition and drug effects. The emphasis is on how developmental stage influences the activity and regulation of drug-metabolizing enzymes, drug transporters, receptors, and intracellular signaling pathways, because these factors collectively drive variability in pharmacokinetics and pharmacodynamics across pediatric life stages.
This opportunity uses the NIH Research Project Grant (R01) mechanism, which generally supports discrete, hypothesis-driven research projects led by a principal investigator (or multiple PIs, when appropriate). In practical terms, that means applicants are expected to propose a clear research plan with strong scientific rationale, appropriate methods, and measurable aims, and to justify why an R01-level effort is needed to answer the proposed questions. The announcement is structured around multiple receipt dates (rather than a single deadline), consistent with many NIH program announcements that accept applications on recurring submission cycles.
Eligible applicants are broad and include many types of U.S. organizations such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses as well as small businesses), independent school districts, and various local, county, and state government entities. It also allows participation by Native American tribal governments and tribal organizations, special district governments, and public housing authorities/Indian housing authorities. Notably, the eligibility language states that foreign institutions may apply, eligible agencies of the federal government may apply, and faith-based or community-based organizations may apply, which widens the pool beyond the typical academic applicants and encourages contributions from diverse settings where pediatric or developmental research capacity exists.
The program is categorized as a discretionary grant and is associated with multiple CFDA numbers spanning environmental health, drug abuse and addiction research, neuroscience and neurological disorders, biomedical research and training, and child health and human development extramural research. That spread signals that developmental pharmacology is viewed as cross-cutting: understanding how children process and respond to medications is relevant not only to general pediatrics but also to environmental exposures, neurologic conditions, and substance-related research. There is no cost sharing or matching requirement, which is typical for many NIH research project grants and means applicants are not required to provide non-federal matching funds as a condition of the award.
From an applicant standpoint, the most responsive projects under this announcement would be those that directly interrogate developmental trajectories in biological determinants of drug response. That could include characterizing age-dependent expression or function of specific metabolizing enzymes (such as CYP pathways), maturation of transporter systems that affect absorption and distribution, developmental differences in receptor density or sensitivity that alter drug efficacy or toxicity, or changes in signaling networks that shift pharmacologic responses during growth. Translational work would often connect these mechanistic insights to dosing, safety, or therapeutic response questions relevant to pediatric populations, with an eye toward improving evidence-based medication use across fetal, neonatal, infant, child, and adolescent stages.
Administratively, the opportunity was posted July 24, 2007, created December 5, 2008, and archived June 23, 2010. The full announcement was historically available through the NIH Grants Guide at the provided link (http://grants.nih.gov/grants/guide/pa-files/PAR-07-416.html). For access issues or technical problems with the posting, the listed point of contact is the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV.
Developmental Pharmacology (R01) (PAR-07-416) FAQs
What is the Developmental Pharmacology (R01) funding opportunity (PAR-07-416)?
PAR-07-416 is a National Institutes of Health (NIH) grant opportunity that supports investigator-initiated research aimed at explaining how normal growth and development shape the way drugs work in the body. It focuses on developmental (age-related) biology and how that biology affects drug response.
What is the main scientific focus of this opportunity?
The central scientific idea is ontogeny: age-dependent changes from fetal life through adolescence, and how those changes influence drug response. The program emphasizes developmental differences in the biological systems that determine drug disposition and drug effects.
What does "ontogeny" mean in the context of this program?
Ontogeny refers to the age-dependent changes that occur as an individual grows, specifically from fetal development through adolescence. In this program, it means studying how those developmental changes alter pharmacokinetics and pharmacodynamics across pediatric life stages.
What types of research projects are encouraged (basic vs. translational)?
Projects can be basic or translational, as long as they advance understanding of developmental differences in key biological systems that drive drug disposition and drug effects.
What key biological systems are highlighted as priorities?
The opportunity highlights developmental stage effects on the activity and regulation of drug-metabolizing enzymes, drug transporters, receptors, and intracellular signaling pathways, because these factors contribute to variability in pharmacokinetics and pharmacodynamics across pediatric stages.
How does this funding opportunity relate to pediatric pharmacokinetics and pharmacodynamics?
The program is specifically concerned with how developmental biology creates variability in pharmacokinetics (how the body handles drugs) and pharmacodynamics (how drugs affect the body) from fetal life through adolescence.
What is the grant mechanism used for this opportunity?
This opportunity uses the NIH Research Project Grant (R01) mechanism.
What does an R01 typically support?
An R01 generally supports a discrete, hypothesis-driven research project led by a principal investigator (or multiple PIs when appropriate). Applicants are expected to propose a clear research plan with strong scientific rationale, appropriate methods, and measurable aims, and to justify why an R01-level effort is needed to answer the proposed questions.
Are multidisciplinary projects expected or allowed?
Yes. Projects are expected to take a multidisciplinary approach.
What kinds of project topics would be considered responsive to PAR-07-416?
Examples of responsive topics described include studies that directly interrogate developmental trajectories in biological determinants of drug response, such as age-dependent expression or function of specific drug-metabolizing enzymes (including CYP pathways), maturation of transporter systems affecting absorption and distribution, developmental differences in receptor density or sensitivity that alter efficacy or toxicity, and changes in intracellular signaling networks that shift responses during growth.
Does the opportunity support research across multiple pediatric life stages?
Yes. The program explicitly frames development from fetal life through adolescence and notes relevance across fetal, neonatal, infant, child, and adolescent stages.
How is translational work described for this opportunity?
Translational work is described as connecting mechanistic insights about developmental biology to dosing, safety, or therapeutic response questions relevant to pediatric populations, with the goal of improving evidence-based medication use across developmental stages.
Are applications accepted on a single deadline or multiple submission cycles?
The announcement is structured around multiple receipt dates rather than a single deadline, consistent with NIH program announcements that accept applications on recurring submission cycles.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses and other than small businesses), independent school districts, and various local, county, and state government entities.
Are Native American tribal governments and tribal organizations eligible?
Yes. The eligibility language allows participation by Native American tribal governments and tribal organizations.
Are special district governments and housing authorities eligible?
Yes. Special district governments and public housing authorities/Indian housing authorities are included in the listed eligible applicant types.
Can foreign institutions apply?
Yes. The eligibility language states that foreign institutions may apply.
Can federal government agencies apply?
Yes. The eligibility language states that eligible agencies of the federal government may apply.
Are faith-based and community-based organizations eligible?
Yes. The eligibility language states that faith-based or community-based organizations may apply.
Is this program a discretionary grant?
Yes. The program is categorized as a discretionary grant.
Are there cost sharing or matching requirements?
No. There is no cost sharing or matching requirement stated for this opportunity.
What subject areas or federal program categories is this opportunity associated with?
The opportunity is associated with multiple CFDA numbers spanning environmental health, drug abuse and addiction research, neuroscience and neurological disorders, biomedical research and training, and child health and human development extramural research. This reflects that developmental pharmacology is treated as cross-cutting across several research domains.
When was this funding opportunity posted and what is its current status?
The opportunity was posted July 24, 2007, created December 5, 2008, and archived June 23, 2010.
Where was the full announcement historically published?
The full announcement was historically available in the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAR-07-416.html.
Who should be contacted for access issues or technical problems with the posting?
For access issues or technical problems with the posting, the listed point of contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Does the information provided specify award amounts or project period limits?
No. The provided information describes the scientific scope, mechanism, eligibility, and administrative details, but it does not specify award amounts, budget caps, or project period limits.
Does the information provided specify review criteria or application formatting requirements?
No. The provided information notes that applicants should propose a clear, hypothesis-driven research plan suitable for an R01, but it does not list specific review criteria or formatting requirements.
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