Opportunity Information: Apply for PA 06 414
Apply for PA 06 414
- The National Institutes of Health in the education food and nutrition health sector is offering a public funding opportunity titled "Diet, Epigenetic Events, and Cancer Prevention (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research.
- This funding opportunity was created on Dec 5, 2008 and posted on May 16, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities City or township governments For profit organizations other than small businesses Private institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Special district governments State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply. Investigators wishing to apply for an R03 grant should be aware that not all NIH Institutes and Centers (ICs) accept investigator initiated R03 applications and that the different NIH ICs may have specific purposes for which they use this funding mechanism. Therefore, all investigators should consult the R03 web site at http://grants.nih.gov/grants/funding/r03.htm as well as the NIH IC staff listed on this web site to determine if an R03 application is appropriate. Information related to the use of R03 awards by NIH ICs that do not participate in this FOA is also listed on the R03 web site. Additional information about special initiatives involving R03 awards can be found by searching the NIH Guide for Grants and Contracts at http://grants.nih.gov/grants/guide/index.html#search, by examining NIH IC web sites, and by consulting with NIH staff. All investigator initiated small grant R03 applications described in this FOA will be assigned to the NIH ICs according to standard PHS referral guidelines and specific program interests. Applicants may submit more than one application, provided each application is scientifically distinct. Small grant support may not be used for thesis or dissertation research.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
Diet, Epigenetic Events, and Cancer Prevention (R03) is an NIH small-grant funding opportunity (PA-06-414) focused on understanding how diet influences epigenetic mechanisms that matter for cancer risk, prevention, and tumor behavior. The core scientific goal is to support clinical and preclinical studies that test how dietary patterns, specific nutrients, and dietary supplements can change DNA methylation, histone posttranslational modifications, and other epigenetic processes that help regulate gene expression. A major emphasis is building clearer connections between diet-driven epigenetic changes (including methylation patterns) and real cancer-related outcomes, such as tumor incidence, progression, or behavior.
A key feature of the program is its push for collaboration between nutrition scientists and epigenetics researchers. The FOA explicitly encourages teams that can link bioactive food components with cancer-preventive properties to measurable epigenetic events involved in cancer biology. Examples of relevant cancer processes named in the announcement include carcinogen metabolism, cell division, differentiation, and apoptosis. The broader idea is to move beyond describing diet or epigenetic marks in isolation and instead map specific dietary exposures to specific epigenetic alterations and then to biologically meaningful cancer endpoints.
Two NIH institutes highlight special interests within the overall scope. NIAAA (alcohol research) calls out projects examining chronic alcohol consumption and how it affects one-carbon metabolism-related factors such as SAM (S-adenosylmethionine), betaine, and folate, along with potential downstream associations with DNA methylation and cancer. NIDDK (diabetes, digestive, and kidney diseases) is especially interested in research on normal and neoplastic conditions in the gastrointestinal tract and related organs, particularly studies centered on epigenetic influences on cell division, differentiation, and/or apoptosis in those tissues.
This announcement uses the NIH R03 mechanism, which is designed for smaller, tightly scoped projects that can be completed relatively quickly with limited resources. The FOA notes that appropriate project types can include pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, and work focused on developing research methods or new research technology. The R03 is not renewable, and it cannot be used to support thesis or dissertation research. The FOA also notes that NIH ran parallel announcements with the same scientific scope using other mechanisms: an R01 (PA-06-412) for larger full-scale projects and an R21 (PA-06-413) for exploratory/developmental work.
Funding levels are capped at modest amounts consistent with the small-grant format. Applicants may request up to $50,000 per year in direct costs for up to two years, for a maximum of $100,000 in direct costs over the two-year period. The FOA specifies that consortium/third-party facilities and administrative costs are not counted within that direct-cost cap. There is no cost-sharing or matching requirement. The number of awards is not predetermined and depends on available funds and how many high-quality, meritorious applications are submitted; award size and duration can vary based on the proposed work.
Eligibility is broad and includes for-profit and nonprofit organizations, public and private institutions (such as universities, hospitals, and laboratories), units of state and local government, eligible federal agencies, and domestic or foreign institutions. Faith-based and community-based organizations are eligible, as are federally recognized tribes, other tribal governments, and tribally designated organizations. For investigators, the FOA is open to any qualified project director/principal investigator with the expertise and resources to conduct the work, and NIH continues to encourage applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities. Multiple applications from the same applicant are allowed as long as each submission is scientifically distinct.
Administratively, the opportunity is listed as discretionary grant funding under NIH and is associated with CFDA program areas that include alcohol research programs and cancer cause, prevention, and biology research (CFDA numbers 93.273, 93.393, and 93.396). The announcement uses multiple receipt dates (rather than a single deadline), and awards are contingent on availability of funds and program priorities. The archived listing indicates it was originally posted May 16, 2006, with an archive date of October 2, 2009, and the full announcement was available through NIH Grants guidance for PA-06-414.
FAQs: Diet, Epigenetic Events, and Cancer Prevention (R03) - NIH (PA-06-414)
What is the Diet, Epigenetic Events, and Cancer Prevention (R03) opportunity?
Diet, Epigenetic Events, and Cancer Prevention (R03) is an NIH small-grant funding opportunity (PA-06-414) that supports research on how diet influences epigenetic mechanisms relevant to cancer risk, cancer prevention, and tumor behavior.
What is the main scientific goal of this funding opportunity?
The core goal is to support clinical and preclinical studies that test how dietary patterns, specific nutrients, and dietary supplements can affect epigenetic processes (such as DNA methylation and histone posttranslational modifications) that regulate gene expression, and to connect those diet-driven epigenetic changes to cancer-related outcomes.
What types of epigenetic mechanisms are specifically mentioned?
The announcement highlights DNA methylation, histone posttranslational modifications, and other epigenetic processes involved in regulating gene expression.
What cancer-related outcomes does the FOA emphasize linking to epigenetic changes?
A major emphasis is building clearer links between diet-driven epigenetic changes (including methylation patterns) and outcomes such as tumor incidence, tumor progression, or tumor behavior.
Does this program focus only on describing epigenetic marks or dietary exposures?
No. The program encourages moving beyond studying diet or epigenetic marks in isolation. The intent is to map specific dietary exposures to specific epigenetic alterations and then to biologically meaningful cancer endpoints.
What kinds of research studies are encouraged (clinical vs. preclinical)?
Both clinical and preclinical studies are within scope, as long as they test diet-related exposures and measure resulting epigenetic events relevant to cancer prevention and biology.
Is collaboration encouraged, and between which fields?
Yes. A key feature of the program is encouraging collaboration between nutrition scientists and epigenetics researchers to better connect bioactive food components and cancer-preventive properties to measurable epigenetic events involved in cancer biology.
What are examples of cancer processes mentioned as relevant to this research?
Examples named include carcinogen metabolism, cell division, differentiation, and apoptosis.
Are dietary supplements included in the scope?
Yes. The FOA explicitly includes studies of dietary patterns, specific nutrients, and dietary supplements as potential exposures that could influence epigenetic mechanisms related to cancer.
Which NIH institutes identified specific interests within the broader topic?
Two institutes are described as highlighting special interests: NIAAA and NIDDK.
What special interests are noted for NIAAA (alcohol research)?
NIAAA calls out projects examining chronic alcohol consumption and how it affects one-carbon metabolism-related factors such as SAM (S-adenosylmethionine), betaine, and folate, along with potential downstream associations with DNA methylation and cancer.
What special interests are noted for NIDDK?
NIDDK is especially interested in research on normal and neoplastic conditions in the gastrointestinal tract and related organs, particularly studies focused on epigenetic influences on cell division, differentiation, and/or apoptosis in those tissues.
What grant mechanism does this opportunity use?
This announcement uses the NIH R03 mechanism, which is intended for smaller, tightly scoped projects that can be completed relatively quickly with limited resources.
What project types does the FOA say are appropriate for an R03 under this announcement?
The FOA notes that appropriate projects can include pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, and projects aimed at developing research methods or new research technology.
Can this R03 be renewed?
No. The R03 mechanism described in the FOA is not renewable.
Can R03 funds under this announcement be used for a thesis or dissertation project?
No. The FOA states that the R03 cannot be used to support thesis or dissertation research.
Are there related NIH opportunities with the same scientific scope but different mechanisms?
Yes. NIH ran parallel announcements with the same scientific scope using an R01 mechanism (PA-06-412) for larger projects and an R21 mechanism (PA-06-413) for exploratory/developmental work.
How much funding can an applicant request?
Applicants may request up to $50,000 per year in direct costs for up to two years, for a maximum of $100,000 in direct costs over the two-year period.
How long can the project period be?
The project can be supported for up to two years under this R03 opportunity, consistent with the described cap.
Do consortium or third-party facilities and administrative (F&A) costs count toward the direct-cost cap?
No. The FOA specifies that consortium/third-party facilities and administrative costs are not counted within the direct-cost cap.
Is cost-sharing or matching required?
No. The FOA states that there is no cost-sharing or matching requirement.
How many awards will be made?
The number of awards is not predetermined. It depends on available funds and the number of high-quality, meritorious applications submitted.
Can award size and project duration vary?
Yes. The FOA notes that award size and duration can vary based on the proposed work, within the small-grant framework described.
What types of organizations are eligible to apply?
Eligibility is broad and includes for-profit and nonprofit organizations, public and private institutions (including universities, hospitals, and laboratories), units of state and local government, eligible federal agencies, and domestic or foreign institutions.
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly listed as eligible.
Are tribal entities eligible?
Yes. Federally recognized tribes, other tribal governments, and tribally designated organizations are included as eligible applicants.
Are foreign institutions eligible?
Yes. The FOA indicates that domestic or foreign institutions are eligible.
Who is eligible to serve as the project director/principal investigator (PD/PI)?
The FOA is open to any qualified PD/PI with the expertise and resources to conduct the proposed work.
Does NIH encourage applications from underrepresented groups?
Yes. NIH continues to encourage applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities.
Can the same applicant submit more than one application?
Yes. Multiple applications from the same applicant are allowed as long as each application is scientifically distinct.
What kind of funding opportunity is this administratively?
It is listed as discretionary grant funding under NIH.
Which CFDA program areas are associated with this opportunity?
The opportunity is associated with CFDA program areas including alcohol research programs and cancer cause, prevention, and biology research, with CFDA numbers 93.273, 93.393, and 93.396.
Does the FOA have a single deadline?
No. The announcement uses multiple receipt dates rather than a single deadline.
Are awards guaranteed if an application is submitted?
No. Awards are contingent on availability of funds and NIH program priorities, and depend on the merit of applications received.
When was this announcement originally posted, and when was it archived?
The archived listing indicates it was originally posted on May 16, 2006, and has an archive date of October 2, 2009.
What is the FOA identifier for this opportunity?
The FOA identifier provided is PA-06-414.
Where was the full announcement made available?
The full announcement was available through NIH Grants guidance for PA-06-414.
Browse more opportunities from the same category: Education Food and Nutrition Health
Next opportunity: Exploratory/Developmental Bioengineering Research Grants(EBRG) R21
Previous opportunity: Diet, Epigenetic Events, and Cancer Prevention (R21)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 06 414
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 06 414) also looked into and applied for these:
| Funding Opportunity |
|---|
| Mechanisms of Alcohol and Drug InducedPancreatitis (R01) Apply for PA 07 067 Funding Number: PA 07 067 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Diet, Epigenetic Events, and Cancer Prevention (R01) Apply for PA 07 175 Funding Number: PA 07 175 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Application of Metabolomics for Translational and Biological Research (R01) Apply for PA 07 301 Funding Number: PA 07 301 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Application of Metabolomics for Translational and Biological Research (R21) Apply for PA 07 302 Funding Number: PA 07 302 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Development of Assays for High Throughput Drug Screening (R01) Apply for PA 07 320 Funding Number: PA 07 320 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Research on the Economics of Diet, Activity, and Energy Balance (R01) Apply for PA 08 078 Funding Number: PA 08 078 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R01) Apply for PA 08 083 Funding Number: PA 08 083 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (R01) Apply for PA 08 243 Funding Number: PA 08 243 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Lab to Marketplace Tools for Brain and Behavioral Research (SBIR R43/R44) Apply for PA 08 071 Funding Number: PA 08 071 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Lab to Marketplace Tools for Biomedical and Behavioral Research (SBIR R43/R44) Apply for PA 08 114 Funding Number: PA 08 114 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Exploratory/Developmental Clinical Research Grants in Obesity (R21) Apply for PA 09 124 Funding Number: PA 09 124 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: $200,000 |
| Biobehavioral Methods to Improve Outcomes Research (R01) Apply for PA 09 125 Funding Number: PA 09 125 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Pilot and Feasibility Clinical Research Studies in Digestive Diseases and Nutrition (R21) Apply for PA 09 151 Funding Number: PA 09 151 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: $200,000 |
| Development and Validation of Disease Biomarkers (R01) Apply for PA 09 204 Funding Number: PA 09 204 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Health Disparities in NIDDK Diseases (R01) Apply for PA 09 262 Funding Number: PA 09 262 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Development of Assays for High Throughput screening for use in Probe and Pre therapeutic Discovery (R01) Apply for PA 10 213 Funding Number: PA 10 213 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Health Promotion Among Racial and Ethnic Minority Males (R01) Apply for PA 10 236 Funding Number: PA 10 236 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
| Lab to Marketplace Tools for Brain and Behavioral Research (SBIR R43/R44) Apply for PA 11 134 Funding Number: PA 11 134 Agency: National Institutes of Health Category: Education Food and Nutrition Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 06 414", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.