Opportunity Information: Apply for PAR 13 094
Apply for PAR 13 094
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Differentiation and Integration of Stem Cells (Embryonic and Induced Pluripotent) Into Developing or Damaged Tissues (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jan 28, 2013 and posted on Jan 28, 2013.
- Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) County governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Special district governments For profit organizations other than small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH grant opportunity "Differentiation and Integration of Stem Cells (Embryonic and Induced Pluripotent) Into Developing or Damaged Tissues (R01)" (Funding Opportunity Number PAR-13-094) is a discretionary research grant designed to push stem cell science beyond the dish and into real biological settings. Its core goal is to support in vivo studies, primarily in animal models and potentially in humans when appropriate, to clarify how stem cells behave, differentiate, and integrate within developing tissues or in tissues that are injured, degenerating, or otherwise diseased. The emphasis is on understanding stem cells in their native context, where signals from neighboring cells, extracellular matrix, inflammation, vascular supply, and other microenvironmental factors strongly shape cell fate and function.
A major scientific priority in this announcement is the systematic profiling and cataloging of changes that occur at both the genetic and epigenetic levels. This includes not only the stem cells themselves but also the surrounding microenvironment that influences them. The FOA highlights the value of mapping how gene expression programs and epigenetic states shift over time as cells move through progressive differentiation. In practical terms, this means studying the transitions from embryonic stem cells (ESCs) into early embryonic lineages, then into progenitor populations, and ultimately into specialized mature cell types. It also encourages investigating adult stem cells and progenitor cells that participate in tissue regeneration and wound healing, where the biology is often complicated by injury-related signals such as hypoxia, immune responses, fibrosis, and remodeling.
Induced pluripotent stem cells (iPSCs) are a central piece of the FOA as well, particularly in the context of regenerative medicine and cell therapy. The announcement calls for research that examines what happens to iPSCs at the site of injury during therapeutic use, with attention to differentiation trajectories, integration into host tissue, and how local cues guide or derail intended outcomes. A key motivation is to determine which mechanisms allow iPSC-derived cells to behave more like their embryonic counterparts, and how researchers can generate iPSCs that more closely match ESCs genetically and epigenetically. This is important because differences in epigenetic memory, incomplete reprogramming, or aberrant gene regulation can affect stability, differentiation potential, and safety.
Safety is an explicit driver of the program. By learning how developmental mechanisms naturally guide cells to mature and integrate correctly, the FOA aims to reduce major risks that have historically limited stem cell therapies, including incomplete differentiation, inappropriate cell fate decisions, abnormal tissue integration, and the possibility of adverse outcomes such as ectopic tissue formation or uncontrolled proliferation. The underlying idea is that therapies will become safer and more effective when they intentionally replicate or leverage normal developmental pathways and regenerative cues rather than forcing differentiation through oversimplified conditions that may not translate in vivo.
Administratively, this opportunity uses the NIH R01 mechanism, supporting hypothesis-driven projects that can build a substantial body of work. The program sits within the NIH mission space and is listed under CFDA 93.865 (Child Health and Human Development Extramural Research), reflecting its connection to developmental biology and tissue formation as well as injury and repair. The FOA does not require cost sharing or matching. The posted date was January 28, 2013, with an original and final closing date of September 7, 2016, and an archive date of October 8, 2016, meaning it is no longer active but remains a useful reference for the kinds of projects NIH has sought in this area. The award ceiling is listed as $500,000.
Eligibility is broad and includes many types of organizations: public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit structures), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district). It also explicitly includes tribal governments and tribal organizations, public housing authorities, independent school districts, and a range of mission-focused institutions such as HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations. Notably, non-U.S. entities are eligible: foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and NIH-defined foreign components are allowed, making this an internationally accessible opportunity consistent with NIH policy.
Overall, PAR-13-094 is best understood as a call for rigorous, in vivo, mechanism-focused stem cell research that connects developmental biology, regenerative repair, and translational safety. It prioritizes studies that track and explain how stem cells and their environments change over time at genetic and epigenetic levels, with the long-term aim of enabling iPSC-based approaches that resemble ESC biology more closely and integrate more predictably and safely into damaged or developing tissues.
FAQs: NIH PAR-13-094 - Differentiation and Integration of Stem Cells (R01)
What is this funding opportunity?
This is an NIH discretionary research grant opportunity titled "Differentiation and Integration of Stem Cells (Embryonic and Induced Pluripotent) Into Developing or Damaged Tissues (R01)" under Funding Opportunity Number (FON) PAR-13-094. It uses the NIH R01 mechanism to support hypothesis-driven research projects.
What is the main scientific goal of PAR-13-094?
The core goal is to move stem cell research beyond in vitro (dish-based) work and support in vivo studies that clarify how stem cells behave, differentiate, and integrate within real biological settings, including developing tissues and injured, degenerating, or diseased tissues.
What types of study settings are emphasized (in vivo vs. in vitro)?
The FOA emphasizes in vivo studies, primarily in animal models, and potentially in humans when appropriate, to understand stem cell differentiation and integration in native tissue contexts.
Why does the FOA emphasize studying stem cells in their native context?
Because stem cell fate and function are strongly shaped by signals present in living tissues, including neighboring cells, extracellular matrix, inflammation, vascular supply, and other microenvironmental factors that can be difficult to replicate accurately in simplified in vitro systems.
What cell types are within scope?
The FOA focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), and it also encourages investigation of adult stem cells and progenitor cells involved in tissue regeneration and wound healing.
How does the FOA describe the differentiation pathway researchers are encouraged to study?
It highlights studying progressive differentiation over time, including transitions from embryonic stem cells into early embryonic lineages, then into progenitor populations, and ultimately into specialized mature cell types.
What kinds of molecular profiling are prioritized?
A major priority is systematic profiling and cataloging of changes at both genetic and epigenetic levels. This includes profiling not only the stem cells but also the surrounding microenvironment that influences them.
Does the FOA focus only on the stem cells themselves?
No. It explicitly emphasizes studying both the stem cells and the microenvironment, including how the tissue context changes genetically and epigenetically in ways that influence stem cell behavior and outcomes.
What does the FOA mean by mapping changes "over time"?
It refers to tracking how gene expression programs and epigenetic states shift as cells move through stages of differentiation and as tissues change during development, injury, degeneration, disease, and repair.
What role do iPSCs play in this FOA?
iPSCs are a central focus, especially for regenerative medicine and cell therapy contexts. The FOA calls for research examining what happens to iPSCs at sites of injury during therapeutic use, including differentiation trajectories and integration into host tissue.
What iPSC-related challenges does this opportunity aim to address?
It aims to understand mechanisms that influence whether iPSC-derived cells behave like embryonic counterparts and how to generate iPSCs that more closely match ESCs genetically and epigenetically. It specifically notes concerns such as epigenetic memory, incomplete reprogramming, and aberrant gene regulation that can affect stability, differentiation potential, and safety.
What does the FOA say about local cues at injury sites?
It highlights that local tissue cues can guide or derail intended therapeutic outcomes, so studies should pay close attention to how the injury microenvironment influences differentiation, integration, and function of transplanted or therapeutically deployed cells.
What injury-related biological factors are specifically mentioned as complicating regeneration studies?
The FOA notes that regeneration and wound-healing contexts can be complicated by signals such as hypoxia, immune responses, fibrosis, and remodeling.
How is safety addressed in PAR-13-094?
Safety is an explicit driver. The FOA aims to reduce risks that have limited stem cell therapies, including incomplete differentiation, inappropriate cell fate decisions, abnormal tissue integration, and adverse outcomes such as ectopic tissue formation or uncontrolled proliferation.
How does understanding development relate to safer stem cell therapies in this FOA?
The FOA is motivated by the idea that therapies can be safer and more effective when they replicate or leverage normal developmental pathways and regenerative cues, rather than relying on oversimplified differentiation conditions that may not translate well in vivo.
What NIH funding mechanism is used?
This opportunity uses the NIH R01 mechanism, intended to support substantial, hypothesis-driven research programs.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
What is the listed award ceiling?
The award ceiling is listed as $500,000.
What CFDA number is associated with this opportunity?
The FOA is listed under CFDA 93.865 (Child Health and Human Development Extramural Research).
When was PAR-13-094 posted, and is it still active?
The posted date was January 28, 2013. The original and final closing date was September 7, 2016, and the archive date was October 8, 2016, which means this opportunity is no longer active.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofits (including 501(c)(3) and other nonprofit structures); for-profit organizations (including small businesses and other for-profits); and government entities at multiple levels (state, county, city/township, and special district).
Are tribal entities eligible?
Yes. The FOA explicitly includes tribal governments and tribal organizations.
Are public housing authorities and school districts eligible?
Yes. The FOA explicitly includes public housing authorities and independent school districts.
Does the FOA encourage participation from mission-focused institutions?
Yes. It explicitly includes and recognizes eligibility for a range of mission-focused institutions, including HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations.
Can non-U.S. organizations apply?
Yes. Foreign organizations and foreign institutions may apply. Non-U.S. components of U.S. organizations are eligible, and NIH-defined foreign components are allowed, consistent with NIH policy.
What kinds of projects does PAR-13-094 appear designed to support?
Based on the description, it is a call for rigorous, in vivo, mechanism-focused stem cell research that connects developmental biology with regenerative repair and translational safety, with a particular emphasis on genetic and epigenetic profiling over time in both cells and their microenvironments.
How should this FOA be viewed today if it is archived?
Although it is no longer active, it remains a useful reference for understanding the kinds of in vivo stem cell integration and differentiation projects NIH has sought, especially those focused on mechanisms, microenvironmental influences, and safety-relevant outcomes.
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