Opportunity Information: Apply for RFA MH 15 500
Apply for RFA MH 15 500
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Dimensional Approaches to Research Classification in Psychiatric Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Apr 8, 2014 and posted on Apr 8, 2014.
- Applicants must submit their applications by Oct 3, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education Special district governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Small businesses For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Dimensional Approaches to Research Classification in Psychiatric Disorders (R01) is a National Institutes of Health (NIH), National Institute of Mental Health (NIMH) funding opportunity that supports research aimed at rethinking how mental disorders are studied in clinical research. Instead of relying primarily on traditional diagnostic categories (for example, the kinds of disorder labels found in standard diagnostic manuals), this program is built around the idea that many important psychological and biological mechanisms do not neatly fit within a single diagnosis. The core goal is to fund studies that classify and investigate psychopathology using experimental, measurable dimensions of functioning tied to genetics, brain circuitry, behavior, and other observable systems. In practical terms, the FOA is trying to move the field toward an evidence-based framework where symptoms and dysfunction are understood through underlying processes that can be measured and compared across people, rather than through broad diagnostic groupings.
This opportunity is directly grounded in the NIMH Research Domain Criteria (RDoC) initiative. RDoC is a research framework designed to organize mental health research around fundamental domains of human functioning and the neural and behavioral systems that support them. The FOA encourages applicants to design studies that can reveal mechanisms shared across multiple disorders, or that explain why individuals with the same diagnosis can look very different clinically. Applicants are expected to align their projects with RDoC criteria and to use the constructs and guidance produced through RDoC consensus workshops. The intention is that, over the long run, findings from this kind of research can help shape future diagnostic systems by anchoring them more firmly in neuroscience, genetics, and behavioral science.
The FOA highlights five major organizing domains in the RDoC draft structure: Negative Valence Systems (processes related to responses to aversive situations such as threat, fear, loss, or frustration), Positive Valence Systems (reward-related processes such as motivation, reward learning, and habit), Cognitive Systems (functions like attention, perception, memory, and cognitive control, including working memory as a specific sub-area), Social Process Systems (processes supporting social behavior and understanding of self and others), and Arousal/Regulatory Systems (systems involved in arousal, sleep-wake regulation, and broader regulatory processes). A key requirement is that proposed projects must focus on at least one construct that has been defined in completed RDoC workshops and described in the associated proceedings and guidance documents. Because RDoC is an evolving framework, applicants are also encouraged to consult the NIMH RDoC website for the most current definitions and expectations.
From an administrative and funding perspective, this is an R01 research grant mechanism, categorized as a discretionary grant under the health funding activity area. The funding opportunity number is RFA-MH-15-500, and it is associated with CFDA number 93.242 (Mental Health Research Grants). The program does not require cost sharing or matching. The FOA listed an estimated total funding amount of $3,000,000, with an award ceiling of $400,000. Key dates provided in the announcement include a posted date of April 8, 2014, and an application closing date of October 3, 2014, with an archive date of November 3, 2014.
Eligibility for this FOA is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations both with and without 501(c)(3) status (including faith-based and community-based organizations); small businesses; for-profit organizations (including those other than small businesses); public housing authorities/Indian housing authorities; and tribal governments and organizations (federally recognized and other than federally recognized). The eligibility list also explicitly includes a range of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign organizations (non-U.S. entities).
Overall, this FOA is aimed at investigators who want to run clinically relevant studies that are mechanistically focused and cross-cutting, using RDoC constructs as the organizing framework. The program is essentially asking researchers to design projects that can clarify how particular neurobehavioral systems operate across individuals, how dysfunction in those systems relates to symptoms and impairment, and how these dimensions might ultimately provide a stronger scientific foundation for understanding, studying, and eventually classifying mental disorders. For full official details, the announcement is linked through NIH at http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-15-500.html.
Frequently Asked Questions (FAQs)
What is the Dimensional Approaches to Research Classification in Psychiatric Disorders (R01) opportunity?
This is a National Institutes of Health (NIH) funding opportunity from the National Institute of Mental Health (NIMH) to support research that studies and classifies psychopathology using measurable dimensions of functioning (for example, mechanisms tied to genetics, brain circuitry, and behavior) rather than relying mainly on traditional diagnostic categories.
Which NIH institute is sponsoring this funding opportunity?
The sponsoring institute is the National Institute of Mental Health (NIMH), within the National Institutes of Health (NIH).
What is the funding opportunity number?
The funding opportunity number is RFA-MH-15-500.
What grant mechanism does this opportunity use?
This opportunity uses the R01 research grant mechanism.
What is the core scientific goal of the FOA?
The core goal is to fund clinically relevant, mechanistically focused studies that classify and investigate mental health-related dysfunction through experimental, measurable dimensions of functioning that can be compared across people, rather than through broad diagnostic groupings.
How is this FOA different from research based on traditional diagnostic categories?
Instead of organizing studies primarily around disorder labels from standard diagnostic manuals, this FOA emphasizes underlying psychological and biological mechanisms that may cut across multiple disorders or help explain why people with the same diagnosis can look very different clinically.
How is this FOA connected to the NIMH Research Domain Criteria (RDoC) initiative?
The FOA is directly grounded in NIMH's Research Domain Criteria (RDoC) initiative, which organizes mental health research around fundamental domains of human functioning and the neural and behavioral systems that support them.
Does an application need to align with RDoC?
Yes. Applicants are expected to align projects with RDoC criteria and use constructs and guidance produced through RDoC consensus workshops.
What are the major RDoC domains highlighted in the FOA?
The FOA highlights five major organizing domains in the RDoC draft structure: Negative Valence Systems, Positive Valence Systems, Cognitive Systems, Social Process Systems, and Arousal/Regulatory Systems.
What is meant by Negative Valence Systems in this FOA?
Negative Valence Systems refer to processes related to responses to aversive situations, such as threat, fear, loss, or frustration.
What is meant by Positive Valence Systems in this FOA?
Positive Valence Systems refer to reward-related processes such as motivation, reward learning, and habit.
What is meant by Cognitive Systems in this FOA?
Cognitive Systems include functions like attention, perception, memory, and cognitive control, and the FOA notes working memory as a specific sub-area within this domain.
What is meant by Social Process Systems in this FOA?
Social Process Systems refer to processes that support social behavior and understanding of self and others.
What is meant by Arousal/Regulatory Systems in this FOA?
Arousal/Regulatory Systems include systems involved in arousal, sleep-wake regulation, and broader regulatory processes.
Is there a required focus on specific RDoC constructs?
Yes. A key requirement is that proposed projects must focus on at least one construct that has been defined in completed RDoC workshops and described in the associated proceedings and guidance documents.
Where should applicants look for the most current RDoC definitions and expectations?
The FOA encourages applicants to consult the NIMH RDoC website because RDoC is an evolving framework and definitions and expectations may be updated over time.
What kinds of research questions does the FOA encourage?
The FOA encourages studies that can reveal mechanisms shared across multiple disorders and studies that can explain why individuals with the same diagnosis can present with very different clinical features. It also emphasizes understanding how dysfunction in specific neurobehavioral systems relates to symptoms and impairment.
What is the long-term intended impact of this research approach?
The FOA states an intention that, over the long run, findings from this research can help shape future diagnostic systems by anchoring them more firmly in neuroscience, genetics, and behavioral science.
Is cost sharing or matching required?
No. The FOA specifies that cost sharing or matching is not required.
How much total funding was estimated for this opportunity?
The FOA listed an estimated total funding amount of $3,000,000.
What is the award ceiling?
The award ceiling listed in the FOA is $400,000.
How is this opportunity categorized from an administrative standpoint?
It is categorized as a discretionary grant under the health funding activity area.
What is the CFDA number associated with this FOA?
The FOA is associated with CFDA number 93.242 (Mental Health Research Grants).
What were the key dates listed in the announcement?
The FOA listed a posted date of April 8, 2014; an application closing date of October 3, 2014; and an archive date of November 3, 2014.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include (among others) various government entities, higher education institutions (public and private), nonprofit organizations (with or without 501(c)(3) status, including faith-based and community-based organizations), small businesses, for-profit organizations, public housing authorities/Indian housing authorities, tribal governments and organizations (federally recognized and other than federally recognized), eligible federal agencies, U.S. territories or possessions, regional organizations, and foreign organizations (non-U.S. entities).
Are state and local governments eligible?
Yes. The eligibility list includes state governments, county governments, city or township governments, and special district governments.
Are schools and universities eligible?
Yes. Eligible applicants include independent school districts, public and state-controlled institutions of higher education, and private institutions of higher education.
Are nonprofit organizations eligible even if they do not have 501(c)(3) status?
Yes. The FOA includes nonprofit organizations both with and without 501(c)(3) status, including faith-based and community-based organizations.
Are small businesses and for-profit organizations eligible?
Yes. The eligibility list includes small businesses and for-profit organizations (including those other than small businesses).
Are tribal governments and tribal organizations eligible?
Yes. The FOA lists tribal governments and organizations, including federally recognized tribal governments and tribal organizations other than federally recognized tribal governments.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The eligibility list explicitly includes foreign organizations (non-U.S. entities).
Does the FOA explicitly include certain institution designations (for example, HBCUs and Hispanic-serving institutions)?
Yes. The eligibility list explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Where can applicants find the official FOA details?
The official announcement is available through NIH at http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-15-500.html.
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