Opportunity Information: Apply for RFA MH 14 050
Apply for RFA MH 14 050
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Dimensional Approaches to Research Classification in Psychiatric Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Mar 8, 2013 and posted on Mar 8, 2013.
- Applicants must submit their applications by Jun 27, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Public and State controlled institutions of higher education Private institutions of higher education County governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Dimensional Approaches to Research Classification in Psychiatric Disorders (R01) (Funding Opportunity Number RFA-MH-14-050) is a National Institutes of Health, National Institute of Mental Health (NIMH) grant opportunity aimed at reshaping how mental disorders are studied in clinical research. Instead of relying primarily on traditional diagnostic categories (such as those used in common clinical diagnostic manuals), this FOA encourages researchers to design studies around experimentally grounded dimensions of behavior and brain function. The central idea is to build a research classification approach that reflects underlying mechanisms more directly, using evidence from genetics, neuroscience, and observable behavior.
This announcement is rooted in NIMH's Research Domain Criteria (RDoC) initiative, which promotes studying mental health and psychopathology through measurable constructs that can cut across multiple disorders. In practice, the FOA is looking for R01 research projects that investigate mechanisms shared across diagnostic boundaries, for example, processes that appear in depression, anxiety, PTSD, substance use, or psychosis in different combinations or levels rather than being treated as separate, siloed conditions. Applications are expected to be explicitly based on RDoC criteria as developed to date and to align with constructs defined through RDoC consensus workshops and accompanying guidance documents.
The FOA organizes the RDoC framework into five major domains that applicants can draw from: Negative Valence Systems (broadly involving responses to aversive situations such as threat, loss, or frustrative nonreward), Positive Valence Systems (reward responsiveness, reward learning, motivation toward positive outcomes), Cognitive Systems (processes such as attention, perception, memory, cognitive control, and related functions including working memory), Social Process Systems (how people perceive and respond to self and others, including social communication and affiliation-related processes), and Arousal/Regulatory Systems (arousal, circadian rhythms, sleep-wake regulation, and other regulatory functions). A key requirement emphasized in the announcement is that proposed studies must focus on at least one construct that has been defined in the relevant RDoC workshops available by the application due date, and applicants are encouraged to consult the NIMH RDoC website for the most current definitions and updates.
From an administrative and funding standpoint, this is a discretionary grant program using the R01 mechanism within the health research area (CFDA 93.242, Mental Health Research Grants). The FOA stated an estimated total funding amount of $3,000,000, with an award ceiling of $400,000, and it does not require cost sharing or matching. The opportunity was posted on March 8, 2013, with an original and current closing date of June 27, 2013, and an archive date of July 28, 2013, indicating it was time-limited and is now archived as originally issued.
Eligibility is broad and includes many types of organizations that commonly participate in NIH funding, such as public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and various governmental entities (state, county, city/township, special district governments, and eligible federal agencies). The eligibility list also explicitly includes a range of specialized and community-serving institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based and community-based organizations, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations).
Overall, the grant opportunity is designed to accelerate research that explains mental health conditions in terms of underlying functional dimensions and measurable constructs, with the longer-term goal of informing future diagnostic systems with stronger biological and behavioral foundations. Applicants were directed to the official FOA page for full details and to NIMH contacts (including the NIH Office of Extramural Research webmaster) for access or technical issues related to the posting.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Dimensional Approaches to Research Classification in Psychiatric Disorders (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-MH-14-050.
Which agency and institute are offering this opportunity?
This is a National Institutes of Health (NIH) opportunity offered by the National Institute of Mental Health (NIMH).
What is the main purpose of this FOA?
The FOA is intended to reshape how mental disorders are studied in clinical research by encouraging studies organized around experimentally grounded dimensions of behavior and brain function, rather than relying primarily on traditional diagnostic categories.
How does this FOA differ from research based on traditional diagnostic categories?
Instead of treating disorders as separate, siloed categories (as commonly presented in clinical diagnostic manuals), this FOA encourages research designs that focus on underlying mechanisms supported by evidence from genetics, neuroscience, and observable behavior, potentially cutting across multiple disorders.
What initiative is this FOA rooted in?
This announcement is rooted in NIMH's Research Domain Criteria (RDoC) initiative.
What is the RDoC approach in the context of this FOA?
RDoC promotes studying mental health and psychopathology through measurable constructs that can cut across multiple disorders, helping researchers investigate dimensions and mechanisms that may appear in different combinations or levels across conditions.
What types of research projects is the FOA seeking?
The FOA is seeking R01 research projects that investigate mechanisms shared across diagnostic boundaries, such as processes that may be relevant to depression, anxiety, PTSD, substance use, or psychosis in varying combinations or degrees.
Do applications need to be explicitly based on RDoC?
Yes. Applications are expected to be explicitly based on RDoC criteria as developed to date and aligned with constructs defined through RDoC consensus workshops and related guidance documents.
Is there a specific requirement about RDoC constructs in proposed studies?
Yes. A key requirement is that proposed studies must focus on at least one construct that has been defined in the relevant RDoC workshops available by the application due date.
Where should applicants look for the most current RDoC definitions and updates?
Applicants are encouraged to consult the NIMH RDoC website for the most current definitions and updates.
What are the five major RDoC domains listed in the FOA?
The FOA lists five major domains applicants can draw from:
- Negative Valence Systems (responses to aversive situations such as threat, loss, or frustrative nonreward)
- Positive Valence Systems (reward responsiveness, reward learning, motivation toward positive outcomes)
- Cognitive Systems (attention, perception, memory, cognitive control, working memory, and related functions)
- Social Process Systems (processes involved in perceiving and responding to self and others, including social communication and affiliation-related processes)
- Arousal/Regulatory Systems (arousal, circadian rhythms, sleep-wake regulation, and other regulatory functions)
What grant mechanism is used for this opportunity?
This opportunity uses the R01 mechanism.
Is this a discretionary grant program?
Yes. The FOA describes it as a discretionary grant program.
What is the CFDA number associated with this program?
The CFDA listing provided is 93.242, identified as Mental Health Research Grants.
How much total funding was estimated under this FOA?
The FOA stated an estimated total funding amount of $3,000,000.
What is the award ceiling stated in the FOA?
The stated award ceiling is $400,000.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
When was this opportunity posted?
The FOA was posted on March 8, 2013.
What was the application closing date?
The original and current closing date listed was June 27, 2013.
Is this FOA still open for applications?
No. The FOA is indicated as time-limited and is archived, with an archive date of July 28, 2013.
Which organizations are eligible to apply?
Eligibility is broad and includes:
- Public and private institutions of higher education
- Nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities)
- For-profit organizations (including small businesses and other for-profits)
- Governmental entities (state, county, city/township, and special district governments)
- Eligible federal agencies
- U.S. territories or possessions and regional organizations
- Non-U.S. entities (foreign organizations)
Are minority-serving and community-serving institutions included in eligibility?
Yes. The eligibility list explicitly includes, among others:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs)
- Faith-based and community-based organizations
Does this FOA allow non-U.S. (foreign) organizations to apply?
Yes. The eligibility list explicitly includes foreign organizations.
What is the longer-term goal described for this research direction?
The FOA describes a longer-term goal of informing future diagnostic systems with stronger biological and behavioral foundations, by accelerating research that explains mental health conditions in terms of underlying functional dimensions and measurable constructs.
Where were applicants directed for full details and technical help?
Applicants were directed to the official FOA page for full details and to NIMH contacts, including the NIH Office of Extramural Research webmaster, for access or technical issues related to the posting.
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