Opportunity Information: Apply for PAR 15 259
Apply for PAR 15 259
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Discovery of the Genetic Basis of Structural Birth Defects and of Childhood Cancers Gabriella Miller Kids First Pediatric Research Program (X01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on May 15, 2015 and posted on May 15, 2015.
- Applicants must submit their applications by Jul 27, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public housing authorities/Indian housing authorities Special district governments Public and State controlled institutions of higher education Independent school districts Small businesses County governments City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity PAR 15-259, titled "Discovery of the Genetic Basis of Structural Birth Defects and of Childhood Cancers - Gabriella Miller Kids First Pediatric Research Program (X01)," is a National Institutes of Health (NIH) initiative designed to expand what researchers know about the genetic causes of serious pediatric conditions. The program focuses on two broad problem areas: (1) structural birth defects, where a child is born with a physical anomaly affecting organs or body structures, and (2) childhood cancers, with a particular interest in understanding genetic factors that contribute to cancer development and to treatment failure in childhood sarcomas. A central feature of the opportunity is that awardees would use whole genome sequencing (WGS) performed at an NHGRI-supported sequencing center, meaning the sequencing component is tied to established, federally supported genomic infrastructure rather than being independently arranged by the applicant.
The main scientific goal is to use WGS to identify and better explain genetic variants and genomic mechanisms that underlie these pediatric diseases. For structural birth defects, applicants are expected to investigate genetic etiology, which typically involves searching for rare or de novo variants, inherited risk variants, structural variants, and other genome-wide changes that could plausibly contribute to developmental disruption. For childhood cancers, the opportunity emphasizes clarifying genetic contributions to disease and, importantly, examining genomic reasons some pediatric sarcomas do not respond to treatment or recur after therapy. This can include studying tumor genomes, germline genomes, or paired tumor-normal samples depending on the project design, with the broader intention of teasing apart which genomic features might predict resistance, relapse, or poor outcomes.
A major programmatic purpose goes beyond any single research project: the resulting sequence data are intended to become part of a shared data resource for the larger pediatric research community. In other words, the work funded through this X01 mechanism is meant to generate high-value genomic datasets that other qualified researchers can reuse, reanalyze, and combine with other datasets to accelerate discovery. NIH also notes that insights gained from these projects will help shape and design future activities of the Gabriella Miller Kids First Pediatric Research Program, so the funded studies serve both as research efforts and as learning opportunities that inform how the Kids First program evolves.
From an administrative and funding standpoint, the opportunity is listed as a discretionary grant under the NIH, with the activity category falling under health (CFDA 93.310, Trans-NIH Research Support). It does not require cost sharing or matching. The posting and creation date were May 15, 2015, with an original and current closing date of July 27, 2015, and an archive date of August 27, 2015, indicating this specific solicitation window has passed, though it remains informative for understanding the program and any follow-on initiatives.
Eligibility is broad and includes many organization types across the public, private, nonprofit, and educational sectors. Eligible applicants include for-profit organizations (other than small businesses), small businesses, nonprofits with and without 501(c)(3) status, private and public institutions of higher education, state and local governments (including counties, cities or townships, independent school districts, special district governments, and public housing authorities/Indian housing authorities), and tribal governments and organizations. The eligibility list also explicitly includes a range of institution types and community-serving organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based or community-based organizations, certain federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations) are also included, reflecting NIH's intent to encourage wide participation in building pediatric genomic resources.
Operationally, this announcement points applicants to the full funding announcement text hosted on the NIH grants site (the additional information link). For technical issues accessing the announcement or linking problems, NIH directs users to contact the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. Overall, the opportunity is best understood as a data-generation and discovery-focused mechanism that leverages high-throughput whole genome sequencing to address fundamental questions in pediatric genetics and oncology while building a community resource that supports future research and program development.
Frequently Asked Questions (FAQs)
What is PAR 15-259?
PAR 15-259 is a National Institutes of Health (NIH) funding opportunity titled "Discovery of the Genetic Basis of Structural Birth Defects and of Childhood Cancers - Gabriella Miller Kids First Pediatric Research Program (X01)." It supports research that uses whole genome sequencing (WGS) to advance understanding of genetic factors behind serious pediatric conditions.
What program is this opportunity associated with?
This opportunity is part of the Gabriella Miller Kids First Pediatric Research Program, an NIH initiative intended to expand knowledge and generate shared genomic data resources for the pediatric research community.
What are the main research areas supported by this opportunity?
The opportunity focuses on two broad areas: (1) structural birth defects (physical anomalies present at birth affecting organs or body structures) and (2) childhood cancers, with a particular interest in pediatric sarcomas and understanding genetic factors related to treatment failure and recurrence.
What is the primary scientific goal of the funded projects?
The main goal is to use whole genome sequencing to identify and explain genetic variants and genomic mechanisms that contribute to structural birth defects and childhood cancers, including factors that may influence cancer development, treatment resistance, relapse, or poor outcomes.
How does whole genome sequencing (WGS) fit into this opportunity?
A central feature is that awardees use WGS performed at an NHGRI-supported sequencing center. This ties the sequencing to established, federally supported genomic infrastructure rather than having applicants independently arrange sequencing.
What types of genetic factors might be studied for structural birth defects?
Projects focused on structural birth defects are expected to investigate genetic etiology, which can include rare variants, de novo variants, inherited risk variants, structural variants, and other genome-wide changes that could plausibly disrupt development.
What types of cancer-focused questions are emphasized?
For childhood cancers, the opportunity emphasizes understanding genetic contributions to disease and examining genomic reasons some pediatric sarcomas do not respond to treatment or recur after therapy.
What types of samples or data can be analyzed in childhood cancer studies?
Depending on project design, studies may examine tumor genomes, germline genomes, or paired tumor-normal samples, with the intent of identifying genomic features linked to resistance, relapse, or poor outcomes.
Is this opportunity only about answering a single research question?
No. A major program purpose is to generate sequence data that become part of a shared data resource for the broader pediatric research community, enabling reuse and reanalysis by other qualified researchers.
How will the data generated by funded projects be used beyond the original study?
The resulting sequence data are intended to be incorporated into a community resource so other researchers can reuse, reanalyze, and combine datasets to accelerate pediatric genetic and cancer discovery.
How does this opportunity affect the future direction of the Kids First program?
NIH notes that insights gained from funded projects will help shape and design future activities of the Gabriella Miller Kids First Pediatric Research Program, meaning funded studies also inform how the program evolves.
What funding mechanism is used for this opportunity?
The opportunity uses the X01 mechanism, described here as a data-generation and discovery-focused approach leveraging WGS performed at an NHGRI-supported sequencing center.
Which federal agency is offering this opportunity?
The opportunity is offered through the National Institutes of Health (NIH).
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
How is this opportunity categorized administratively?
It is listed as a discretionary grant under NIH, with an activity category under health. It references CFDA 93.310 (Trans-NIH Research Support).
Who is eligible to apply?
Eligibility is broad and includes many organization types across public, private, nonprofit, and educational sectors, including for-profit organizations (other than small businesses), small businesses, nonprofits (with and without 501(c)(3) status), and private and public institutions of higher education.
Are government entities eligible to apply?
Yes. Eligibility includes state and local governments, including counties, cities or townships, independent school districts, special district governments, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations are explicitly included in the eligibility list.
Are minority-serving institutions mentioned as eligible?
Yes. The eligibility list explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included as eligible applicants.
Are non-U.S. organizations eligible?
Yes. Non-U.S. entities (foreign organizations) are included in the eligibility list.
Are U.S. territories or possessions included as eligible?
Yes. U.S. territories or possessions are included in the eligibility list.
Where can applicants find the full funding announcement?
The announcement directs applicants to the full funding announcement text hosted on the NIH grants site via the additional information link.
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement or link problems, NIH directs users to contact the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
When was this opportunity posted, and what were the key dates?
The posting/creation date was May 15, 2015. The original and current closing date was July 27, 2015, and the archive date was August 27, 2015.
Is this specific solicitation still open?
No. Based on the closing date (July 27, 2015) and archive date (August 27, 2015), this specific solicitation window has passed, though it may still be informative for understanding the program and possible follow-on initiatives.
What is the overall intent of the opportunity in plain terms?
Overall, it is a discovery and data-generation focused opportunity that leverages federally supported whole genome sequencing to advance research in pediatric structural birth defects and childhood cancers while building a shared genomic resource for the research community.
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