Opportunity Information: Apply for RFA AI 09 018
Apply for RFA AI 09 018
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Dissecting the Early HIV Immune Response A Systems Biology Approach (P01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy, Immunology and Transplantation Research.
- This funding opportunity was created on Jun 2, 2009 and posted on Jun 2, 2009.
- Applicants must submit their applications by Dec 1, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Eligible applicants include: City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses County governments Special district governments Independent school districts Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Dissecting the Early HIV Immune Response: A Systems Biology Approach (P01)" (Funding Opportunity Number RFA-AI-09-018) is a National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) funding announcement aimed at supporting large, coordinated research programs that use systems biology to study what happens immunologically in the earliest stages of HIV or SIV exposure and infection. The central idea is that early immune events can strongly shape downstream outcomes, and that understanding these events requires looking beyond single genes, pathways, or cell types. Instead, applicants are expected to analyze networks of interacting components (for example, integrated immune cell behavior, signaling pathways, gene expression patterns, cytokine networks, and other multi-parameter data) to build a more complete, predictive picture of how early immune responses influence whether exposure leads to infection, how infection establishes itself, and how the host response evolves.
This FOA specifically solicits Program Project Grant (P01) applications, which are meant for multi-project, team-based efforts built around a unifying theme and shared overall objectives. Under this structure, each application must include at least two distinct research projects that are clearly connected by a common scientific focus, plus an Administrative and Data Management Core. The required core component signals that NIAID is emphasizing coordination, standardization, and robust handling of complex datasets, which is especially important for systems biology work where data types are diverse and integration across projects is a major part of the scientific value. In practical terms, the expectation is that the individual projects will not operate as isolated studies; they should be interdependent and designed to collectively generate, manage, and interpret datasets in a way that enables modeling or prediction of system behavior related to early HIV/SIV immune responses.
From a funding standpoint, NIAID indicated an intent to commit a total of $5.0 million in FY2010 (total costs) to support an anticipated one to two awards. That combination of relatively high total funding and a small number of awards suggests a competitive, high-impact program intended to fund a limited set of comprehensive research hubs rather than many smaller, independent projects. The posting date for the announcement was June 2, 2009, and the original and current closing date listed is December 1, 2009, with an archive date of January 1, 2010, indicating this is an older, time-limited opportunity that has since been archived.
Eligibility is broad and includes many types of domestic and non-domestic institutions and organizations. Eligible applicants listed include public and private institutions of higher education; nonprofits with or without 501(c)(3) status (other than institutions of higher education); small businesses and certain for-profit organizations; and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility section also highlights additional categories such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, U.S. territories or possessions, and foreign (non-U.S.) entities and regional organizations, among others. The FOA explicitly states there is no cost sharing or matching requirement, which means applicants are not required to provide non-federal funds as a condition of receiving the award.
Programmatically, the emphasis on early HIV/SIV immune response and systems biology implies that strong applications would likely combine high-dimensional experimental approaches (such as multi-omics profiling, advanced immunophenotyping, longitudinal sampling, and computational modeling) with rigorous data management and integration strategies to reveal how multiple immune components interact over time. The stated objective is not only descriptive understanding but also the ability to predict system behavior in ways that inform outcomes of exposure or infection. In other words, the program is geared toward building models and integrated frameworks that can explain why early immune responses differ across individuals or experimental conditions, and how those differences might relate to protection, susceptibility, or disease trajectory.
The sponsoring agency is NIH (specifically NIAID), and the activity aligns with CFDA number 93.855 (Allergy, Immunology and Transplantation Research). The full announcement was made available through the NIH grants guide, and contact information is provided through the NIH Office of Extramural Research (OER) webmaster addresses for technical access issues.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "Dissecting the Early HIV Immune Response: A Systems Biology Approach (P01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AI-09-018.
Which agency is sponsoring this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH), specifically the National Institute of Allergy and Infectious Diseases (NIAID).
What type of grant mechanism is being solicited?
This FOA specifically solicits Program Project Grant (P01) applications, which are designed for coordinated, multi-project research programs organized around a unifying theme and shared objectives.
What scientific area does this FOA focus on?
The FOA focuses on the earliest immune events that occur during HIV or SIV exposure and infection, with the goal of understanding how early immune responses shape downstream outcomes.
What approach is emphasized by this FOA?
The FOA emphasizes a systems biology approach, meaning applicants are expected to study networks of interacting immune components rather than isolated genes, pathways, or single cell types.
What kinds of biological networks or data types does the FOA suggest analyzing?
Examples mentioned include integrated immune cell behavior, signaling pathways, gene expression patterns, cytokine networks, and other multi-parameter datasets that can be combined to build a more complete and predictive picture of early immune responses.
What is the central goal of studying early immune events in HIV/SIV exposure?
The central idea is that early immune events can strongly shape later outcomes, including whether exposure leads to infection, how infection becomes established, and how the host response evolves over time. The FOA also highlights building an understanding that supports modeling or prediction of system behavior.
How many research projects must be included in a P01 application under this FOA?
Each application must include at least two distinct research projects that are clearly connected by a common scientific focus.
Are any core components required?
Yes. The application must include an Administrative and Data Management Core.
Why is an Administrative and Data Management Core required?
Based on the FOA description, the required core reflects NIAID's emphasis on coordination, standardization, and robust handling of complex, diverse systems biology datasets, including integration across projects.
Do the individual projects in the P01 need to be connected to each other?
Yes. The FOA indicates that projects should not function as isolated studies. They are expected to be interdependent and designed to collectively generate, manage, and interpret datasets in a way that enables integrated analysis and prediction.
What level of funding did NIAID plan to commit, and for what period?
NIAID indicated an intent to commit a total of $5.0 million in FY2010 (total costs) for this FOA.
How many awards were anticipated?
The FOA anticipated making one to two awards.
What does the small number of anticipated awards suggest about competitiveness?
With relatively high total funding and only one to two awards anticipated, the FOA reads as a competitive, high-impact program intended to support a limited number of comprehensive, coordinated research hubs.
What are the key dates listed for this FOA?
The FOA lists a posting date of June 2, 2009, a closing date of December 1, 2009 (shown as both original and current), and an archive date of January 1, 2010.
Is this FOA still active?
Based on the dates provided (including an archive date of January 1, 2010), this is an older, time-limited opportunity that has been archived.
Is cost sharing or matching required?
No. The FOA explicitly states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes domestic and non-domestic institutions and organizations. The FOA lists eligible applicants such as public and private institutions of higher education; nonprofits (with or without 501(c)(3) status, other than institutions of higher education); small businesses; certain for-profit organizations; and a wide range of government entities.
What types of government entities are listed as eligible?
The FOA includes state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility section explicitly includes foreign (non-U.S.) entities and regional organizations among eligible applicants.
Does the FOA highlight any specific institution types as eligible?
Yes. The FOA highlights multiple categories, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, U.S. territories or possessions, and others.
What is the CFDA number associated with this opportunity?
The activity aligns with CFDA 93.855 (Allergy, Immunology and Transplantation Research).
Where was the full announcement made available?
The full announcement was made available through the NIH grants guide.
Who is listed for technical access or website support issues?
Contact information is provided through the NIH Office of Extramural Research (OER) webmaster addresses for technical access issues.
What kind of research strategies would align with the FOA's stated emphasis?
Based on the program description, strong alignment would come from combining high-dimensional experimental approaches (for example, multi-parameter immune profiling, longitudinal sampling, and computational modeling) with rigorous data management and integration strategies to support network-level analysis and prediction of early HIV/SIV immune response behavior.
Is the FOA focused on descriptive biology only, or does it aim for prediction?
The FOA goes beyond descriptive understanding and emphasizes building a predictive picture of how early immune responses influence outcomes related to exposure, infection establishment, and evolution of host responses.
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