Opportunity Information: Apply for PAR 16 236

  • The HHS-NIH11 in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Dissemination and Implementation Research in Health (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.213, 93.242, 93.273, 93.279, 93.307, 93.361, 93.399, 93.853, 93.855, 93.856, 93.865, 93.866,.
  • This funding opportunity was created on May 10, 2016 and posted on May 10, 2016.
  • Applicants must submit their applications by May 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PAR 16 236

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Opportunity Summary:

Dissemination and Implementation Research in Health (R21) (PAR 16-236) is a National Institutes of Health (NIH) grant opportunity designed to support research that helps move proven health interventions into real-world use. The focus is not on inventing entirely new clinical or public health interventions, but on understanding how to spread and integrate evidence-based practices more effectively across the settings where people actually receive care and services. This includes public health systems, clinical practices, and community-based environments where uptake can be uneven, slow, or limited by practical constraints.

The work supported under this announcement centers on identifying, developing, testing, evaluating, and refining strategies that improve dissemination and implementation. In practice, that means studying approaches that encourage organizations, providers, and communities to adopt interventions that already have evidence behind them. The FOA explicitly points to a wide range of evidence-based practices that could be the target of implementation efforts, such as behavioral interventions; prevention programs; early detection and screening approaches; diagnostic tools and workflows; treatment protocols; disease management interventions; and quality improvement programs. A key expectation is that projects will address the barriers and facilitators that affect whether these practices are adopted, delivered with fidelity, sustained over time, and scaled to reach the intended populations.

Beyond studying implementation strategies themselves, the announcement also encourages proposals that strengthen the field of dissemination and implementation (D and I) science by improving research methods and measurement. That can include developing or refining D and I study designs, testing implementation outcomes and metrics, creating better measures of adoption and fidelity, improving ways to assess context and organizational readiness, or advancing analytic approaches that help explain why certain strategies work in some settings but not others. In other words, the FOA supports both applied projects that solve specific implementation problems and methodological projects that make future D and I research more rigorous and useful.

This opportunity uses the NIH R21 mechanism, which is commonly associated with exploratory, developmental, or early-stage projects. The listed award ceiling is $200,000, indicating a relatively modest budget compared to larger research project grants and reinforcing the expectation of focused, well-justified studies that can generate actionable findings, preliminary evidence, or refined tools and methods that can later be expanded through larger awards. The funding instrument type is a grant, and the opportunity category is discretionary, reflecting standard NIH competitive research funding.

Eligibility is broad and includes many types of organizations that participate in health research and service delivery. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as described in the full announcement. This breadth fits the nature of D and I work, which often requires partnerships among academic researchers, health systems, community organizations, and government agencies to test implementation approaches under real operating conditions.

The sponsoring agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), listed as HHS-NIH11. The FOA was posted and created on May 10, 2016, and the closing date shown in the source data is May 7, 2019. The opportunity is also associated with multiple CFDA numbers (now often referred to under Assistance Listings), reflecting participation across several NIH institutes and centers and a broad relevance to different health domains.

Overall, this FOA is aimed at closing the gap between what research shows works and what is routinely delivered in health and community settings. Successful applications typically emphasize real-world impact, clear implementation challenges, strong partnerships with delivery settings, well-specified dissemination or implementation strategies, and outcomes that meaningfully capture adoption, delivery quality, reach, sustainability, and the contextual factors that drive success or failure.

Frequently Asked Questions (FAQs)

What is the purpose of the Dissemination and Implementation Research in Health (R21) opportunity (PAR 16-236)?

This NIH funding opportunity supports research on how to move proven, evidence-based health interventions into routine, real-world use. The emphasis is on improving the spread (dissemination) and integration (implementation) of practices that already have evidence behind them, especially in settings where uptake is uneven, slow, or constrained by practical realities.

Is this grant meant to fund brand-new clinical or public health interventions?

No. The focus is not on inventing entirely new interventions. Instead, it supports studies that examine how to adopt, deliver, sustain, and scale evidence-based practices more effectively in real-world systems and communities.

What kinds of settings does this opportunity focus on?

The opportunity targets real-world environments where people receive services, including public health systems, clinical practices, and community-based settings. It is designed for situations where implementation is challenging due to organizational, resource, workflow, or contextual constraints.

What types of evidence-based practices can be the focus of a project?

The FOA points to a broad range of evidence-based practices that could be targeted for dissemination or implementation efforts, including:

  • Behavioral interventions
  • Prevention programs
  • Early detection and screening approaches
  • Diagnostic tools and workflows
  • Treatment protocols
  • Disease management interventions
  • Quality improvement programs

What kinds of research activities are supported under this FOA?

Projects may identify, develop, test, evaluate, and refine strategies that improve dissemination and implementation. In practical terms, this can include studying approaches that help organizations, providers, and communities adopt evidence-based practices and deliver them consistently and effectively over time.

What is meant by dissemination and implementation (D and I) strategies in this announcement?

Within the scope described, D and I strategies are approaches intended to increase the adoption and integration of evidence-based practices across real service settings. The announcement emphasizes understanding what helps or hinders uptake, delivery quality, and longer-term sustainment.

What kinds of barriers and facilitators should projects address?

The FOA expects projects to examine factors that influence whether evidence-based practices are adopted, delivered with fidelity, sustained, and scaled. This can include barriers and facilitators affecting organizations, providers, communities, and the context in which services are delivered.

Does the FOA support research on sustainability and scaling of interventions?

Yes. A key expectation is that studies address not only initial adoption and delivery, but also sustainment over time and scaling to reach intended populations.

Can projects focus on improving D and I research methods and measurement?

Yes. The FOA explicitly encourages proposals that strengthen dissemination and implementation science by improving methods and measurement, such as refining study designs, testing implementation outcomes and metrics, improving measures of adoption and fidelity, assessing context and organizational readiness, and advancing analytic approaches that explain why strategies work in some settings but not others.

What is the NIH activity code or mechanism for this opportunity?

This opportunity uses the NIH R21 mechanism, which is commonly used for exploratory, developmental, or early-stage projects.

What is the award ceiling for this R21 opportunity?

The listed award ceiling is $200,000, indicating a modest budget relative to larger research project grants and an expectation of focused, well-justified studies that can generate actionable findings, preliminary evidence, or refined tools and methods.

What is the funding instrument and category?

The funding instrument type is a grant, and the opportunity category is discretionary, consistent with competitive NIH research funding.

Who is the sponsoring agency for this FOA?

The sponsoring agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), listed as HHS-NIH11.

Which organizations are eligible to apply?

Eligibility is broad and includes many types of organizations involved in health research and service delivery, including:

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Federally recognized Native American tribal governments
  • Other Native American tribal organizations
  • Public housing authorities and Indian housing authorities
  • Nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education)
  • For-profit organizations (other than small businesses)
  • Small businesses
  • Other entities as described in the full announcement

Why is eligibility so broad for a D and I funding opportunity?

Dissemination and implementation research often requires collaboration among research teams and real delivery settings, such as health systems, community organizations, and government agencies. Broad eligibility reflects the practical nature of testing implementation approaches under real operating conditions.

What dates are associated with this FOA?

The FOA was posted and created on May 10, 2016. The closing date shown in the provided source data is May 7, 2019.

Are there specific health topics or domains covered?

The opportunity is described as broadly relevant across health domains and is associated with multiple CFDA numbers (now often referred to under Assistance Listings), reflecting participation across several NIH institutes and centers.

What makes an application a good fit for this FOA based on the description provided?

Based on the information provided, strong fit applications typically emphasize real-world impact, clearly define the implementation challenge, include strong partnerships with service delivery settings, specify dissemination or implementation strategies, and measure outcomes that capture adoption, delivery quality (including fidelity), reach, sustainability, and contextual factors that influence success or failure.

What outcomes does the FOA highlight as important to measure?

The description highlights outcomes related to adoption, delivery quality and fidelity, reach, sustainability, and contextual influences (such as organizational readiness and other setting-specific factors) that help explain variation in results across sites or systems.

What is the overall goal of this funding opportunity?

The overall goal is to close the gap between what research shows works and what is routinely delivered in health and community settings, by improving how evidence-based practices are disseminated and implemented under real-world conditions.

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