Opportunity Information: Apply for PA 08 166
Apply for PA 08 166
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Dissemination, Implementation, and Operational Research for HIV Prevention Interventions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.361 Nursing Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on May 8, 2008.
- Applicants must submit their applications by May 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Public and State controlled institutions of higher education State governments City or township governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses County governments Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH funding opportunity PA 08-166, titled "Dissemination, Implementation, and Operational Research for HIV Prevention Interventions (R01)," supports U.S.-focused research aimed at improving how proven HIV prevention interventions are transferred into real-world practice. Rather than funding the discovery of brand-new prevention approaches, this announcement emphasizes the later stages of the public health pipeline: getting evidence-based interventions adopted, delivered well, sustained over time, and adapted appropriately across settings and populations. The goal is to strengthen the science behind technology transfer, dissemination, implementation, and operational research so that interventions with strong evidence actually reach people and communities in ways that reduce HIV risk and improve prevention outcomes.
This FOA is sponsored by three NIH institutes: the National Institute of Mental Health (NIMH), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Institute of Nursing Research (NINR). The research priorities and gaps were identified through a collaborative process involving both NIH and the Centers for Disease Control and Prevention (CDC), which signals an intent to align research with practical public health needs and on-the-ground implementation challenges. In plain terms, the announcement is looking for studies that explain what helps or blocks the use of effective HIV prevention programs in clinics, community organizations, schools, correctional settings, and other service systems, and what strategies reliably improve uptake, fidelity, reach, equity, and sustainability.
The primary mechanism of support is the NIH Research Project Grant (R01), which is typically used for mature, hypothesis-driven projects with substantial scope and rigorous methods. At the same time, the announcement notes that similar scientific aims could also be pursued through other NIH mechanisms, including the R03 (Small Research Grant), R21 (Exploratory/Developmental Research Grant), and the NIMH R34 (Clinical Exploratory/Developmental Research Grant), by applying under their respective parent FOAs (PA-06-180, PA-06-181, and PA-06-248). This structure gives investigators flexibility: smaller pilot work, early-stage development, and preparatory clinical implementation efforts can be proposed under the smaller or developmental mechanisms, while larger, more definitive studies align with the R01.
Funding decisions under PA 08-166 are described as contingent on the availability of funds and the submission of a sufficient number of high-quality, meritorious applications. The opportunity was posted May 8, 2008, with an original and final closing date of May 7, 2011, and it was archived June 7, 2011. Even though it is archived now, the description remains useful as a clear snapshot of NIH priorities at the time around implementation science for HIV prevention and the types of applicants and project scopes NIH sought to attract.
Eligibility is broad and includes many organization types that commonly participate in public health research. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (including small businesses and other for-profits), state and local governments (state, county, city/township), independent school districts, special district governments, public housing authorities/Indian housing authorities, and multiple tribal entities (federally recognized tribal governments as well as other tribal organizations). The eligibility language also explicitly includes a range of mission-focused and community-anchored institutions and organizations, such as faith-based and community-based organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), U.S. territories or possessions, regional organizations, and even non-U.S. (foreign) entities. This wide eligibility reflects the reality that HIV prevention implementation often depends on partnerships across academic, clinical, public health, and community systems, and that meaningful dissemination and implementation research frequently requires embedded relationships with the organizations that deliver services.
In terms of content, the announcement centers on four related research areas. Technology transfer focuses on how knowledge, tools, training, and intervention packages move from research settings into practice settings. Dissemination research examines how information and interventions are communicated and spread to intended audiences and service systems, including which channels, messaging, and distribution strategies increase awareness and demand. Implementation research studies the methods and strategies that help organizations adopt and integrate evidence-based interventions, including workforce training, supervision models, workflow redesign, quality improvement, and policy supports. Operational research looks at practical, system-level questions about how programs function day to day, such as barriers in service delivery, costs and efficiencies, and how operational decisions affect outcomes, reach, and sustainability. Across all of these areas, the underlying theme is improving real-world impact by understanding and addressing the gaps between evidence and routine practice.
The FOA is issued by the National Institutes of Health and is associated with CFDA numbers tied to the participating institutes and research portfolios: 93.242 (Mental Health Research Grants), 93.361 (Nursing Research), and 93.865 (Child Health and Human Development Extramural Research). It specifies that there is no cost sharing or matching requirement. The full archived announcement was made available through the NIH grants guide at the link provided in the source, and NIH also listed contact support through the NIH Office of Extramural Research (OER) webmaster for access and linking issues.
FAQs: NIH PA 08-166 - Dissemination, Implementation, and Operational Research for HIV Prevention Interventions (R01)
What is the NIH funding opportunity PA 08-166?
PA 08-166 is an NIH Funding Opportunity Announcement (FOA) titled "Dissemination, Implementation, and Operational Research for HIV Prevention Interventions (R01)." It supports research focused on improving how proven HIV prevention interventions are transferred into real-world practice in the United States.
What is the main purpose of this FOA?
The purpose is to strengthen the science of technology transfer, dissemination, implementation, and operational research so that evidence-based HIV prevention interventions are adopted, delivered with quality, sustained over time, and adapted appropriately across settings and populations.
Does this FOA fund the discovery of new HIV prevention interventions?
No. This FOA emphasizes later stages of the public health pipeline, focusing on getting interventions with strong evidence into routine practice rather than developing brand-new prevention approaches.
What does "U.S.-focused" research mean in this opportunity?
It means the research emphasis is on improving the transfer and use of proven HIV prevention interventions in U.S. settings and service systems where HIV prevention is delivered.
Which NIH institutes sponsor PA 08-166?
The FOA is sponsored by three NIH institutes: the National Institute of Mental Health (NIMH), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Institute of Nursing Research (NINR).
How was the research agenda for this FOA informed?
Research priorities and gaps were identified through a collaborative process involving NIH and the Centers for Disease Control and Prevention (CDC), indicating an effort to align studies with practical public health needs and real implementation challenges.
What types of real-world settings are relevant for proposed studies?
The FOA highlights practical settings such as clinics, community organizations, schools, correctional settings, and other service systems where HIV prevention interventions are delivered and sustained.
What kinds of research questions does the FOA encourage?
It encourages studies that explain what helps or blocks the use of effective HIV prevention programs and what strategies improve adoption, delivery quality (including fidelity), reach, equity, and sustainability in routine practice.
What is the primary NIH funding mechanism for this FOA?
The primary mechanism is the NIH Research Project Grant (R01), generally used for mature, hypothesis-driven projects with substantial scope and rigorous methods.
Are other NIH grant mechanisms relevant to the same scientific aims?
Yes. The FOA notes that similar aims could be pursued through other mechanisms by applying under their respective parent FOAs: R03 (Small Research Grant; PA-06-180), R21 (Exploratory/Developmental Research Grant; PA-06-181), and the NIMH R34 (Clinical Exploratory/Developmental Research Grant; PA-06-248).
How does the FOA describe when an R01 versus smaller mechanisms might be appropriate?
It describes flexibility: smaller pilot work, early-stage development, and preparatory clinical implementation efforts may fit R03, R21, or NIMH R34 mechanisms, while larger, more definitive studies align with the R01 mechanism.
Is funding guaranteed if an application is submitted?
No. Funding decisions are described as contingent on the availability of funds and the submission of a sufficient number of high-quality, meritorious applications.
What were the key dates for PA 08-166?
The FOA was posted on May 8, 2008. The original and final closing date was May 7, 2011. It was archived on June 7, 2011.
Is PA 08-166 still open for applications?
No. It is archived, which indicates it is no longer accepting applications under that announcement.
Why might an archived FOA still be useful?
Even though it is closed, the archived description provides a snapshot of NIH priorities at the time related to implementation science for HIV prevention, including the kinds of research topics, settings, and applicant types NIH sought to support.
Who is eligible to apply under this FOA?
Eligibility is broad and includes public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations); for-profit organizations (including small businesses); state and local governments; independent school districts; special district governments; public housing authorities/Indian housing authorities; and tribal entities (federally recognized tribal governments and other tribal organizations).
Does the eligibility language include community-anchored organizations?
Yes. It explicitly includes faith-based and community-based organizations, reflecting the role of community partners in implementing HIV prevention interventions.
Are minority-serving institutions mentioned as eligible?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities (TCCUs).
Are U.S. territories or possessions included?
Yes. The eligibility language includes U.S. territories or possessions.
Are regional organizations included as eligible applicants?
Yes. Regional organizations are explicitly included in the eligibility description.
Can non-U.S. (foreign) entities apply?
Yes. The eligibility description explicitly includes non-U.S. (foreign) entities, even though the research focus is described as U.S.-focused.
What four research areas does the FOA emphasize?
The FOA centers on technology transfer, dissemination research, implementation research, and operational research, all aimed at improving real-world impact by closing gaps between evidence and routine practice.
What is meant by "technology transfer" in this FOA?
Technology transfer refers to how knowledge, tools, training, and intervention packages move from research settings into practice settings.
What is meant by "dissemination research" in this FOA?
Dissemination research examines how information and interventions are communicated and spread to intended audiences and service systems, including which channels, messaging, and distribution strategies increase awareness and demand.
What is meant by "implementation research" in this FOA?
Implementation research studies methods and strategies that help organizations adopt and integrate evidence-based interventions. The FOA gives examples such as workforce training, supervision models, workflow redesign, quality improvement, and policy supports.
What is meant by "operational research" in this FOA?
Operational research focuses on practical, system-level questions about day-to-day program functioning, including service delivery barriers, costs and efficiencies, and how operational decisions affect outcomes, reach, and sustainability.
Does the FOA mention specific outcomes or implementation goals?
Yes. It highlights improving uptake, fidelity, reach, equity, and sustainability, as well as appropriate adaptation across settings and populations.
Is there a cost sharing or matching requirement?
No. The FOA specifies that there is no cost sharing or matching requirement.
What CFDA numbers are associated with this FOA?
The FOA is associated with CFDA numbers 93.242 (Mental Health Research Grants), 93.361 (Nursing Research), and 93.865 (Child Health and Human Development Extramural Research).
Where was the full announcement made available?
The full archived announcement was made available through the NIH Grants Guide, using the link provided in the source description of the opportunity.
Who is listed for support related to access or linking issues?
NIH listed contact support through the NIH Office of Extramural Research (OER) webmaster for access and linking issues.
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| Reducing Risk Behaviors by Promoting Positive Youth Development (R01) Apply for PA 08 241 Funding Number: PA 08 241 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Reducing Risk Behaviors by Promoting Positive Youth Development (R03) Apply for PA 08 242 Funding Number: PA 08 242 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Neurotechnology Research, Development, and Enhancement (SBIR R43/R44) Apply for PA 07 389 Funding Number: PA 07 389 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
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| Womens Mental Health in Pregnancy and the Postpartum Period (R01) Apply for PA 09 174 Funding Number: PA 09 174 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Womens Mental Health in Pregnancy and the Postpartum Period (R21) Apply for PA 09 175 Funding Number: PA 09 175 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $200,000 |
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