Opportunity Information: Apply for 13 506

  • The National Science Foundation in the science and technology and other research and development sector is offering a public funding opportunity titled "Division of Integrative Organismal Systems" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 47.074 Biological Sciences.
  • This funding opportunity was created on Jan 2, 2013 and posted on Nov 5, 2012.
  • Applicants must submit their applications by Aug 2, 2013 Preliminary Proposal Due Date(s) (required) (due by 5 p.m. proposers local time) January 18, 2013 Third Friday in January, Annually Thereafter Full Proposal Deadline(s) August 02, 2013 First Friday in August, Annually Thereafter By Invitation Only. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $55,000,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 200 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:

The National Science Foundation (NSF) Division of Integrative Organismal Systems (IOS) grant opportunity supports basic research that explains how and why organisms are built the way they are and how they function. The central idea is that the organism is treated as a fundamental unit of biological organization, so proposed projects should aim to produce insight at the whole-organism level rather than focusing only on isolated parts. IOS particularly encourages systems-style approaches, meaning projects that integrate multiple components (for example, genes, development, physiology, morphology, behavior, and environment) in ways that generate broader conceptual or theoretical understanding. Competitive proposals are expected to go beyond describing mechanisms and instead build toward generalizable explanations, predictions, or models of emergent organismal properties.

The scientific scope is intentionally broad and spans many areas of organismal biology. Topics explicitly highlighted include developmental biology and the evolution of developmental processes; nervous system development, structure, and function; physiological processes; functional morphology; symbioses and other multi-species relationships; how organisms interact with both living (biotic) and nonliving (abiotic) environments; and animal behavior. IOS indicates that it welcomes proposals across all research areas supported by the division, so investigators working in diverse organismal systems and approaches can potentially align, as long as the work centers on organismal form and function and contributes to integrative understanding.

A key feature of this opportunity is its two-stage, invitation-based submission process for IOS Core Programs. Investigator-initiated proposals must begin with a preliminary proposal, which undergoes merit review. Full research proposals are only accepted if the team is invited to submit one based on the preliminary review outcome. In other words, unsolicited full proposals are not accepted into the IOS Core Programs under this solicitation, and the preliminary step is required. The solicitation also imposes a submission cap: each investigator may submit no more than two preliminary proposals per year as a Principal Investigator (PI) or co-PI in response to this IOS solicitation, though there is no limit on participation as a collaborator or senior personnel. These caps apply to this solicitation specifically and do not limit submissions to other NSF programs or solicitations.

From an administrative and funding standpoint, this is a discretionary NSF grant program within the Science and Technology and other Research and Development category, associated with CFDA number 47.074 (Biological Sciences). The opportunity anticipated roughly 200 awards and listed an estimated total funding level of $55,000,000, with no cost sharing or matching requirement. Eligibility is described as unrestricted (open to any type of entity), subject to any clarifications that may appear in the full announcement text.

The timeline described in the posting sets an annual cadence. Preliminary proposals are due by 5 p.m. local time on the third Friday in January each year (for the cited year, January 18, 2013). Full proposals, when invited, are due by 5 p.m. local time on the first Friday in August each year (for the cited year, August 2, 2013), and submission is explicitly “by invitation only.” The funding opportunity was originally posted November 5, 2012, created January 2, 2013, and later archived September 2, 2017. For official details, IOS points applicants to NSF Publication 13-506, with general access and linking issues routed through NSF’s Grants.gov support channel (grantsgovsupport@nsf.gov).

Frequently Asked Questions (FAQs)

What is the purpose of this NSF IOS grant opportunity?

This opportunity from the National Science Foundation (NSF) Division of Integrative Organismal Systems (IOS) supports basic research aimed at explaining how and why organisms are built the way they are and how they function. A central expectation is that the organism is treated as a fundamental unit of biological organization, with projects producing insight at the whole-organism level.

What kind of research is IOS looking for under this opportunity?

IOS is looking for integrative, systems-style research that connects multiple biological components (for example, genes, development, physiology, morphology, behavior, and environment) to generate broader conceptual or theoretical understanding. Competitive proposals are expected to move beyond describing mechanisms and build toward generalizable explanations, predictions, or models of emergent organismal properties.

Does this opportunity support research focused only on isolated parts (like a single gene or pathway)?

Based on the opportunity description, proposals should aim for insight at the whole-organism level rather than focusing only on isolated parts. Work can include components like genes or physiology, but the emphasis is on integrating components in ways that advance organism-level understanding.

What does IOS mean by a "systems-style" approach?

In this solicitation, a systems-style approach refers to projects that integrate multiple components of biology and context (such as genes, development, physiology, morphology, behavior, and environment) to produce broader conceptual or theoretical insight, rather than isolated findings about a single component.

What scientific areas are included in the scope?

The scope is intentionally broad across organismal biology. Topics explicitly highlighted include developmental biology and evolution of developmental processes; nervous system development, structure, and function; physiological processes; functional morphology; symbioses and other multi-species relationships; interactions with biotic and abiotic environments; and animal behavior.

Is the opportunity limited to certain organisms or organismal systems?

The description states that IOS welcomes proposals across all research areas supported by the division, and eligibility is described as unrestricted (open to any type of entity), subject to clarifications in the full announcement. The main fit consideration described is whether the work centers on organismal form and function and contributes to integrative understanding.

Are proposals expected to generate models or predictions?

Yes. The description indicates competitive proposals are expected to go beyond describing mechanisms and build toward generalizable explanations, predictions, or models of emergent organismal properties.

What is the submission process for IOS Core Programs under this solicitation?

The IOS Core Programs use a two-stage, invitation-based process for investigator-initiated proposals. Applicants must first submit a preliminary proposal for merit review. Full research proposals are accepted only if the team is invited to submit one based on the preliminary review outcome.

Can applicants submit a full proposal without submitting a preliminary proposal?

No. The opportunity states that unsolicited full proposals are not accepted into the IOS Core Programs under this solicitation, and the preliminary proposal step is required.

Are full proposals accepted from everyone who submits a preliminary proposal?

No. Full proposals are submitted "by invitation only" after the preliminary proposal undergoes merit review.

How many preliminary proposals can an investigator submit each year?

Each investigator may submit no more than two preliminary proposals per year as a Principal Investigator (PI) or co-PI in response to this IOS solicitation.

Is there a limit on participating as a collaborator or senior personnel?

No. The submission cap applies to preliminary proposals submitted as PI or co-PI under this solicitation, and the description states there is no limit on participation as a collaborator or senior personnel.

Do these submission caps affect proposals to other NSF programs?

No. The caps apply to this solicitation specifically and do not limit submissions to other NSF programs or solicitations.

What is the CFDA number associated with this opportunity?

The opportunity is associated with CFDA number 47.074, Biological Sciences.

What kind of funding program is this described as?

It is described as a discretionary NSF grant program within the Science and Technology and other Research and Development category.

How many awards and how much total funding are anticipated?

The posting anticipated roughly 200 awards and listed an estimated total funding level of $55,000,000.

Is cost sharing or matching required?

No. The posting states there is no cost sharing or matching requirement.

Who is eligible to apply?

Eligibility is described as unrestricted (open to any type of entity), subject to any clarifications that may appear in the full announcement text.

When are preliminary proposals due?

Preliminary proposals are due by 5 p.m. local time on the third Friday in January each year (the cited example date is January 18, 2013).

When are full proposals due (if invited)?

Invited full proposals are due by 5 p.m. local time on the first Friday in August each year (the cited example date is August 2, 2013). The solicitation notes that full proposal submission is by invitation only.

Is this opportunity still open?

The posting indicates the opportunity was later archived on September 2, 2017. For current status and any active successor opportunities, applicants are directed to the official NSF materials referenced in the announcement.

Where can applicants find the official NSF publication for this opportunity?

The posting points applicants to NSF Publication 13-506 for official details.

Where should technical access or linking issues related to Grants.gov be directed?

The announcement routes general access and linking issues through NSF's Grants.gov support channel at grantsgovsupport@nsf.gov.

When was the opportunity posted, created, and archived?

The opportunity was originally posted on November 5, 2012, created on January 2, 2013, and later archived on September 2, 2017.

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