Opportunity Information: Apply for RFA RM 13 018
Apply for RFA RM 13 018
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "DNA Sequencing Core for an Undiagnosed Diseases Network (UDN) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Aug 7, 2013 and posted on Aug 6, 2013.
- Applicants must submit their applications by Nov 19, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public housing authorities/Indian housing authorities County governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Small businesses City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
This funding opportunity, RFA-RM-13-018, called "DNA Sequencing Core for an Undiagnosed Diseases Network (UDN) (U01)," is a National Institutes of Health (NIH) discretionary grant solicitation aimed at creating a single, centralized DNA Sequencing Core to support patients enrolled in the Undiagnosed Diseases Network (UDN). The central idea is to fund one coordinated sequencing hub that can provide high-quality DNA sequencing services for UDN cases, with the goal of improving diagnostic discovery for individuals whose conditions have remained unexplained after standard clinical evaluation. By establishing a dedicated core, NIH is signaling the need for consistency, efficiency, and shared standards across the network, so that sequencing data are generated and handled in a uniform way that supports reliable analysis, interpretation, and collaboration across UDN sites.
The award mechanism is a cooperative agreement (U01), which matters because it typically involves substantial scientific or programmatic involvement by NIH staff compared with a standard grant. In practice, this means the sequencing core would be expected to operate as an active partner within the UDN framework rather than as a standalone service provider. The funded group would likely be coordinating closely with NIH and UDN investigators on priorities, workflows, quality expectations, reporting, and how sequencing outputs feed into downstream interpretation efforts. The funding activity is categorized under Health, and the associated CFDA number listed is 93.310 (Trans-NIH Research Support), indicating this opportunity supports a cross-NIH, network-oriented research infrastructure function rather than a narrow institute-specific project.
Key dates show this was a time-limited competition posted on August 6, 2013 (created August 7, 2013), with an original and final application due date of November 19, 2013, and an archive date of December 20, 2013. In other words, it is not an open, rolling program; it was a targeted solicitation intended to stand up a specific core capability for the UDN during that period.
Eligibility is broad across U.S.-based organizations and government entities, reflecting NIH interest in attracting either academic, nonprofit, governmental, or private-sector groups that can demonstrate technical and operational capacity for centralized sequencing at scale. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other than small businesses), and a wide range of governmental units (state, county, city/township governments, special district governments, and public housing authorities/Indian housing authorities). The FOA also explicitly includes various mission-focused institution types and community-oriented organizations under "Other Eligible Applicants," such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and regional organizations. This breadth suggests NIH wanted to prioritize capability and readiness to run a high-performing sequencing core, regardless of sector, as long as the applicant could meet federal requirements and integrate effectively with the UDN.
At the same time, the FOA clearly restricts foreign involvement: non-U.S. entities (foreign institutions) are not eligible to apply; non-U.S. components of U.S. organizations are not eligible; and foreign components, as defined in the NIH Grants Policy Statement, are not allowed. Those constraints are consistent with an infrastructure-like award tied to a U.S.-based network and likely reflect governance, data handling, compliance, and coordination considerations for human genomic data generated for UDN patients.
No cost sharing or matching is required, which is typical for many NIH research and research-support awards and reduces barriers for applicants by not requiring institutional matching funds. The listed agency is NIH, and the FOA provides a primary link to the full announcement on the NIH grants site. For access or technical issues, the contact pathway is through the NIH Office of Extramural Research (OER) webmaster email (FBOWebmaster@OD.NIH.GOV), which is framed as support for problems accessing or linking to the announcement rather than scientific or programmatic questions.
Overall, the opportunity is best understood as NIH funding to stand up a centralized sequencing infrastructure component for the UDN via a cooperative agreement, with broad domestic eligibility, no matching requirement, strict prohibition on foreign components, and an emphasis on coordinated network operations to generate consistent, high-quality DNA sequencing data for undiagnosed patient cases.
Frequently Asked Questions (FAQs)
What is the funding opportunity RFA-RM-13-018?
RFA-RM-13-018 is an NIH funding opportunity titled "DNA Sequencing Core for an Undiagnosed Diseases Network (UDN) (U01)." It is a discretionary grant solicitation intended to create a single, centralized DNA Sequencing Core to support patients enrolled in the Undiagnosed Diseases Network (UDN).
What is the main purpose of this opportunity?
The main purpose is to fund one coordinated sequencing hub that can provide high-quality DNA sequencing services for UDN cases. The goal is to improve diagnostic discovery for individuals whose conditions remain unexplained after standard clinical evaluation.
What will the DNA Sequencing Core do for the UDN?
The Sequencing Core is intended to generate DNA sequencing data for UDN patients in a consistent, efficient, and standardized way across the network. This uniformity is meant to support reliable analysis, interpretation, and collaboration among UDN sites.
How many sequencing cores does NIH intend to fund under this FOA?
Based on the description, NIH is signaling the intent to establish a single, centralized DNA Sequencing Core (one coordinated sequencing hub) for the UDN.
What type of award mechanism is used (U01) and why does it matter?
The award mechanism is a cooperative agreement (U01). This matters because a U01 typically involves substantial scientific or programmatic involvement by NIH staff compared with a standard grant. In practice, the funded sequencing core is expected to operate as an active partner within the UDN framework rather than as a standalone service provider.
What kind of involvement from NIH should an awardee expect under a U01?
The FOA indicates close coordination with NIH and UDN investigators on priorities, workflows, quality expectations, reporting, and how sequencing outputs feed into downstream interpretation efforts. This reflects the cooperative nature of the U01 mechanism.
Which federal agency is offering this opportunity?
The agency listed for this opportunity is the National Institutes of Health (NIH).
What is the CFDA number associated with this funding opportunity?
The associated CFDA number listed is 93.310 (Trans-NIH Research Support).
What does CFDA 93.310 suggest about the nature of the project?
CFDA 93.310 (Trans-NIH Research Support) indicates this opportunity supports a cross-NIH, network-oriented research infrastructure function rather than a narrow institute-specific project.
Is this an open, ongoing program or a time-limited competition?
It is a time-limited competition. The information provided indicates it was a targeted solicitation intended to stand up a specific core capability for the UDN during a defined period.
When was the opportunity posted and when were applications due?
The opportunity was posted on August 6, 2013 (created August 7, 2013). The original and final application due date was November 19, 2013.
What does the archive date mean for applicants?
The archive date is listed as December 20, 2013, which indicates the opportunity is no longer active and is presented as an archived solicitation rather than an open call for applications.
Who is eligible to apply?
Eligibility is broad for U.S.-based organizations and government entities. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other than small businesses), and multiple types of U.S. governmental units (state, county, city/township, special district governments, and public housing authorities/Indian housing authorities).
Are mission-focused and community-based organizations eligible?
Yes. The FOA explicitly includes "Other Eligible Applicants" such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), and faith-based or community-based organizations, as well as regional organizations.
Are for-profit companies eligible to apply?
Yes. For-profit organizations are included as eligible applicants, including small businesses and organizations other than small businesses.
Are foreign (non-U.S.) institutions eligible to apply?
No. Non-U.S. entities (foreign institutions) are not eligible to apply.
Can a U.S. organization apply if it includes a non-U.S. component?
No. Non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed under this FOA.
Does this opportunity allow any foreign components at all?
No. The FOA states that foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Is cost sharing or matching required?
No. The opportunity specifies that no cost sharing or matching is required.
What topic area does NIH categorize this funding under?
The funding activity is categorized under Health.
What is NIH trying to achieve by centralizing sequencing for the UDN?
NIH is signaling the need for consistency, efficiency, and shared standards across the network so that sequencing data are generated and handled uniformly. This is intended to support reliable analysis, interpretation, and collaboration across UDN sites for undiagnosed patient cases.
Where can applicants find the full official announcement?
The FOA provides a primary link to the full announcement on the NIH grants site (NIH Grants).
Who should be contacted for technical issues accessing the announcement?
For access or technical issues (such as problems accessing or linking to the announcement), the contact pathway provided is the NIH Office of Extramural Research (OER) webmaster email: FBOWebmaster@OD.NIH.GOV.
Is the provided contact intended for scientific or programmatic questions?
No. The contact is framed as support for problems accessing or linking to the announcement, rather than for scientific or programmatic questions.
What kind of operational role is the sequencing core expected to play within the UDN?
The sequencing core is expected to integrate with the UDN as a coordinated partner, aligning on priorities, workflows, quality expectations, reporting, and ensuring sequencing outputs can feed into downstream interpretation efforts across the network.
What is the overall takeaway about this opportunity?
This opportunity is best understood as NIH funding to stand up a centralized sequencing infrastructure component for the UDN via a cooperative agreement, with broad domestic eligibility, no matching requirement, a strict prohibition on foreign components, and an emphasis on coordinated network operations to generate consistent, high-quality DNA sequencing data for undiagnosed patient cases.
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