Opportunity Information: Apply for W81XWH 14 ALSRP TDA
Apply for W81XWH 14 ALSRP TDA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Amyotrophic Lateral Sclerosis Therapeutic Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Apr 1, 2014 and posted on Apr 1, 2014.
- Applicants must submit their applications by Aug 20, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,800,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Amyotrophic Lateral Sclerosis Therapeutic Development Award is a U.S. Army-sponsored funding opportunity focused on moving promising ALS treatments through the preclinical stage toward eventual clinical advancement. The central aim is therapeutic development rather than basic discovery, meaning the program is looking for practical, product-oriented work that can generate actionable evidence about a candidate therapy's potential. Projects are expected to produce data and/or therapeutic agents that meaningfully de-risk the next steps in translation, with the broader intent of accelerating new treatment options for ALS.
This award specifically supports preclinical assessment of therapeutics for ALS. The studies are expected to be empirical and product-driven, emphasizing real-world testing and development activities that inform whether a therapy is viable, safe enough, and sufficiently effective in relevant preclinical contexts. While a hypothesis-driven approach is allowed, the guiding priority is that the work remains centered on therapeutics rather than purely mechanistic biology. In practical terms, applicants should align proposed research with clear development milestones and measurable outputs that advance a defined therapeutic candidate or therapeutic strategy.
The funding mechanism allows support through either a cooperative agreement or a grant, and it falls under the Department of Defense research and development portfolio (CFDA 12.420, Military Medical Research and Development). The opportunity anticipated making two awards, with an estimated total funding amount of $4.8 million, and it does not require cost sharing or matching funds. Eligibility is listed as unrestricted, meaning it is broadly open to any type of applicant entity, subject to any additional eligibility details that may appear in the full announcement.
Administratively, the opportunity was posted on April 1, 2014, with an application closing date of August 20, 2014, and it was later archived on September 19, 2014. The sponsoring agency is the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA). For technical issues accessing the full announcement, the contact provided is the CDMRP Help Desk at 301-682-5507 or help@eBRAP.org.
FAQs: DoD Amyotrophic Lateral Sclerosis (ALS) Therapeutic Development Award
What is the DoD ALS Therapeutic Development Award?
The DoD Amyotrophic Lateral Sclerosis (ALS) Therapeutic Development Award is a U.S. Army-sponsored funding opportunity designed to move promising ALS treatments through the preclinical stage and position them for eventual clinical advancement. The program centers on therapeutic development work that can generate actionable evidence about a candidate therapy.
What is the main goal of this funding opportunity?
The central aim is therapeutic development rather than basic discovery. The program is looking for practical, product-oriented research that produces data and/or therapeutic agents that meaningfully de-risk next translation steps, with the broader intent of accelerating new ALS treatment options.
What stage of research does this award support?
This award specifically supports preclinical assessment of therapeutics for ALS. The focus is on development and testing activities that inform whether a therapy is viable for continued development and eventual clinical advancement.
What kinds of projects are a good fit?
Projects are expected to be empirical and product-driven, emphasizing real-world testing and development tasks. Competitive projects align proposed work with clear development milestones and measurable outputs that advance a defined therapeutic candidate or therapeutic strategy.
Is basic or mechanistic ALS research supported?
The priority is therapeutics rather than purely mechanistic biology. A hypothesis-driven approach is allowed, but the work needs to stay centered on therapeutic development and practical evidence generation for a candidate therapy.
What types of outcomes are expected from funded projects?
Projects are expected to produce data and/or therapeutic agents that reduce risk for the next steps in translation. In other words, the work should generate actionable results that help determine whether the therapeutic approach is viable, safe enough, and sufficiently effective in relevant preclinical contexts.
Does the opportunity emphasize milestones and measurable deliverables?
Yes. Applicants are expected to align proposed research with clear development milestones and measurable outputs that advance a defined therapeutic candidate or strategy.
Who is the sponsoring agency?
The sponsoring agency is the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA).
What funding mechanisms are available?
Support may be provided through either a cooperative agreement or a grant.
What is the CFDA number and program area for this opportunity?
The opportunity falls under the Department of Defense research and development portfolio: CFDA 12.420, Military Medical Research and Development.
How many awards were anticipated?
The opportunity anticipated making two awards.
What was the estimated total funding amount?
The estimated total funding amount was $4.8 million.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching funds.
Who was eligible to apply?
Eligibility is listed as unrestricted, meaning it is broadly open to any type of applicant entity, subject to any additional eligibility details that may appear in the full announcement.
When was the opportunity posted?
The opportunity was posted on April 1, 2014.
What was the application deadline?
The application closing date was August 20, 2014.
Is this opportunity still active?
No. It was archived on September 19, 2014.
What should applicants do if they have trouble accessing the full announcement?
For technical issues accessing the full announcement, the contact provided is the CDMRP Help Desk at 301-682-5507 or help@eBRAP.org.
Is this program intended to accelerate new ALS treatments?
Yes. The broader intent is to accelerate new treatment options for ALS by moving promising therapeutics through preclinical development with product-focused evidence.
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