Opportunity Information: Apply for W81XWH 12 ALSRP TDA
Apply for W81XWH 12 ALSRP TDA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Amyotrophic Lateral Sclerosis Therapeutic Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Mar 8, 2012 and posted on Mar 8, 2012.
- Applicants must submit their applications by Jul 24, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,800,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Amyotrophic Lateral Sclerosis (ALS) Therapeutic Development Award is a U.S. Department of Defense research funding opportunity focused on accelerating potential treatments for ALS through preclinical therapeutic development. The core purpose of the program is to support studies that generate practical, decision-ready evidence about candidate therapeutics before they move toward clinical testing. Projects are expected to be empirical and product driven, meaning the work should be centered on evaluating a therapeutic agent or intervention in a way that meaningfully advances it along the development pipeline. While hypothesis-driven elements can be included, the emphasis must remain firmly on therapeutics and on producing actionable data that supports advancement of new ALS therapies.
This opportunity was released by the Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the broader military medical research and development assistance listing (CFDA 12.420). It was offered as either a cooperative agreement or a grant within the Science and Technology and other Research and Development activity category. The announcement anticipated making two awards, with an estimated total funding level of $4,800,000 across all awards. There was no cost sharing or matching requirement, which means applicants were not required to contribute non-federal funds as a condition of receiving an award.
Eligibility for the program was described as unrestricted, indicating it was open to any type of entity, assuming no additional limitations were specified elsewhere in the full announcement under eligibility clarifications. The funding opportunity was posted on March 8, 2012, and the application window closed on July 24, 2012, with the opportunity later archived on August 23, 2012. The overall expectation of funded work was that the therapeutic agents evaluated and/or the datasets produced would be strong enough to directly support the next steps in ALS therapy development, such as optimizing candidates, strengthening the preclinical evidence base, or preparing for later-stage translational milestones.
For applicants or organizations that had difficulty accessing the full announcement, administrative support was available through the Congressionally Directed Medical Research Programs (CDMRP) Help Desk at 301-682-5507 or via email at help@cdmrp.org.
DoD ALS Therapeutic Development Award - FAQs
What is the DoD Amyotrophic Lateral Sclerosis (ALS) Therapeutic Development Award?
It is a U.S. Department of Defense (DoD) research funding opportunity focused on accelerating potential treatments for ALS by supporting preclinical therapeutic development. The program is aimed at moving candidate therapeutics forward by generating practical, decision-ready evidence before clinical testing.
What is the main goal of this funding opportunity?
The core purpose is to support empirical, product-driven studies that evaluate a therapeutic agent or intervention and produce actionable data that can directly inform next development steps (for example, optimizing candidates, strengthening preclinical evidence, or preparing for later translational milestones).
What kind of work does the program prioritize?
The program prioritizes preclinical therapeutic development work that is centered on evaluating a candidate therapeutic. Projects are expected to be empirical and product driven, with an emphasis on generating practical evidence that helps determine whether and how a therapeutic should advance along the development pipeline.
Are hypothesis-driven research projects allowed?
Hypothesis-driven elements may be included, but the emphasis must remain firmly on therapeutics and on producing actionable data that supports advancement of new ALS therapies.
What does "product driven" mean in this context?
"Product driven" means the proposed work should be centered on a therapeutic agent or intervention and designed to generate development-relevant evidence, rather than being primarily exploratory or mechanism-focused without a clear path to advancing a specific therapeutic candidate.
What stage of research is supported (preclinical or clinical)?
This opportunity focuses on preclinical therapeutic development, specifically generating decision-ready evidence before a candidate moves toward clinical testing.
What outcomes were expected from funded projects?
Funded work was expected to produce evidence and/or datasets strong enough to directly support next steps in ALS therapy development, such as candidate optimization, strengthening the preclinical evidence base, or preparing for later-stage translational milestones.
Which agency released and administered this opportunity?
The opportunity was released by the Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA), under the broader military medical research and development assistance listing.
What is the CFDA listing associated with this program?
The announcement was issued under CFDA 12.420.
What funding mechanism(s) were used for awards?
The opportunity was offered as either a cooperative agreement or a grant.
What activity category was this opportunity listed under?
It was listed under the Science and Technology and other Research and Development activity category.
How many awards were expected to be made?
The announcement anticipated making two awards.
What was the estimated total funding level?
The estimated total funding level was $4,800,000 across all awards.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement, meaning applicants were not required to contribute non-federal funds as a condition of receiving an award.
Who was eligible to apply?
Eligibility was described as unrestricted, meaning it was open to any type of entity, assuming no additional limitations were specified elsewhere in the full announcement under eligibility clarifications.
When was the opportunity posted?
It was posted on March 8, 2012.
What was the application deadline?
The application window closed on July 24, 2012.
Is this funding opportunity still open?
No. The opportunity was later archived on August 23, 2012.
Where could applicants get help if they could not access the full announcement?
Administrative support was available through the Congressionally Directed Medical Research Programs (CDMRP) Help Desk.
How can the CDMRP Help Desk be contacted?
Phone: 301-682-5507
Email: help@cdmrp.org
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