DoD Breast Cancer Breakthrough Award Level 3 Award | Apply Online

Opportunity Summary:

The DoD Breast Cancer Breakthrough Award Level 3 (Funding Opportunity Number W81XWH 15 BCRP BREAKTHROUGH2 FL3) is a U.S. Army Medical Research Acquisition Activity (USAMRAA) funding opportunity intended to back breast cancer research that is genuinely positioned to change the field, not just add another incremental step. The program is built around the idea of "impact" and expects applicants to make a clear case that their work could meaningfully accelerate progress toward ending breast cancer. Importantly, the Department of Defense is not limiting impact to immediate patient-facing outcomes; instead, proposals must explain a believable pathway to clinical impact for people with breast cancer or those at risk, even if the project itself is not the final clinical deliverable.

Level 3 is specifically aimed at advanced translational research that is close enough to human application to support near-term clinical investigation. In practice, this means projects should be beyond early discovery and should be positioned to move a promising concept toward clinical testing, validation, or implementation. The announcement explicitly notes that small-scale clinical trials may apply, which signals that proposals can include early clinical studies when they are well-justified and appropriately designed for the stage of development. The broader Breakthrough Award mechanism can support projects ranging from small to large scale and across different levels of idea maturity, but this particular announcement covers only Funding Level 3; separate announcements were planned for Funding Levels 1 and 2.

A notable feature is the Partnering PI Option, which encourages meaningful collaboration between two principal investigators. Under this structure, there is an Initiating PI and a Partnering PI, and each PI receives a separate award while contributing jointly to a single, integrated research project. The program emphasizes that both investigators should play substantial roles in shaping the project narrative, statement of work, and other core components, and that each PI must bring distinct expertise rather than duplicating the same role. Collaborations can be new or existing, but the application needs to explain why doing the work together creates added value compared with running two separate projects. The program also discourages investigators from serving as a Partnering PI on multiple applications unless those applications clearly pursue different research questions, which is meant to keep collaborations focused and substantive.

The opportunity places strong expectations on team composition and engagement. The PI or PI team is expected to assemble a robust, appropriately skilled group with the breast cancer-relevant expertise needed to execute a translational project and, where applicable, clinical components such as recruitment, oversight, and evaluation. A required and central element is consumer advocate involvement: every application must include at least two breast cancer consumer advocates who are integrated throughout planning and implementation rather than added as a symbolic advisory layer. These advocates are expected to contribute to core aspects such as refining the research question, shaping the study design, providing oversight input, advising on recruitment approaches, and participating in evaluation. The announcement also sets clear eligibility and independence standards for advocates: they must be individuals diagnosed with breast cancer, active in a breast cancer advocacy organization, and not employees of any participating organization on the application. Their role is intended to provide independent, objective input focused on patient relevance and real-world impact, and they are expected to have sufficient knowledge of breast cancer issues and research to participate effectively.

From an administrative standpoint, this is a discretionary funding opportunity using a cooperative agreement or grant mechanism under the Science and Technology and other Research and Development category. The CFDA listing is 12.420 (Military Medical Research and Development). The agency anticipated making about three awards, with an estimated total funding amount of $11.25 million, and it did not require cost sharing or matching. Eligibility was broadly unrestricted (open to any entity type), subject to any specific clarifications in the full announcement. The opportunity was posted July 23, 2015, with an application closing date of December 21, 2015, and it was later archived on January 20, 2016. For access issues, applicants were directed to the CDMRP Help Desk at 301-682-5507.

Browse more opportunities from the same agency: Dept. of the Army USAMRAA

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Previous opportunity: FY 2015 Marine Minerals Branch (MMB)

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