Opportunity Information: Apply for W81XWH 15 BCRP BREAKTHROUGH FL12
Apply for W81XWH 15 BCRP BREAKTHROUGH FL12
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer Breakthrough Award Levels 1 and 2" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Mar 3, 2015 and posted on Mar 3, 2015.
- Applicants must submit their applications by Apr 22, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $30,800,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 30 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Breast Cancer Breakthrough Award Levels 1 and 2 (Funding Opportunity Number W81XWH 15 BCRP BREAKTHROUGH FL12) is a Department of the Army, USAMRAA-managed funding opportunity within the Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program. Its purpose is to fund promising breast cancer research that has a strong chance of producing true breakthroughs, not just small stepwise gains. The central expectation is impact: proposed work should be positioned to significantly accelerate progress toward ending breast cancer, whether the payoff is expected in the near term or further out. Even when immediate clinical testing is not part of the project, applicants are expected to clearly explain how the research could plausibly translate into clinical impact for people who have breast cancer or who are at risk.
A major theme of this mechanism is that projects can range from small to large and can sit at different points along the research pipeline, as long as the work is clearly framed around breakthrough potential. The program offers two distinct funding levels under this announcement, and applicants are responsible for choosing the level that fits the scope and maturity of the proposed science. Importantly, the funding level selection is meant to be driven by what the project is trying to accomplish (scope, readiness, and stage of development), not simply by how large a budget the team wants to request. The announcement also notes that additional Breakthrough Award levels (Levels 3 and 4) exist but are competed under a separate opportunity, so this particular solicitation is focused only on Levels 1 and 2.
Funding Level 1 is intended for innovative, high-risk/high-reward ideas that are still at the earliest stage of development. This level is designed to give investigators room to test bold concepts and generate proof-of-concept evidence that could open up entirely new lines of investigation. A key feature is that preliminary data are not required, which makes Level 1 a better fit for well-justified concepts that are compelling but not yet extensively supported by existing results. The expectation is that the work could rapidly clarify whether a new approach is viable and worth pursuing at a larger scale.
Funding Level 2 targets research that is more mature and already backed by preliminary data. Projects proposed at this level should be positioned to make significant advances toward clinical translation, meaning the work should not only be scientifically interesting but also oriented toward moving closer to interventions, diagnostics, risk reduction strategies, or other clinically relevant outcomes. Where relevant, applicants are expected to show efficacy in in vivo models, reflecting the program's emphasis on demonstrating biological and translational credibility beyond purely exploratory or in vitro findings. Level 2 therefore fits teams that have already established a foundation and can make a strong case for the next set of studies needed to drive the work toward human impact.
The opportunity also includes a Partnering PI Option that is meant to support real, productive collaborations. Under this structure, two principal investigators participate as an Initiating PI and a Partnering PI, and each receives a separate award. While their submission requirements differ, both investigators are expected to play substantial roles in shaping the project, including joint responsibility for core elements like the Project Narrative and Statement of Work. The program encourages collaborations across similar or different disciplines, but it requires applicants to clearly spell out what each PI uniquely contributes and why the research is stronger as a coordinated partnership rather than two separate efforts. New collaborations are welcome but not mandatory. At the same time, the program discourages token or overextended partnering arrangements, noting that applicants should avoid being listed as a Partnering PI on multiple applications unless the projects truly address distinct questions. It also explicitly states that a mentor and their current postdoctoral fellow or junior investigator pairing as Initiating and Partnering PIs does not align with the intent of this collaboration option.
Administratively, this is a discretionary funding opportunity offered as grants and cooperative agreements within the Science and Technology and other Research and Development activity category (CFDA 12.420, Military Medical Research and Development). The competition anticipated around 30 awards, with an estimated total funding amount of $30.8 million, and it does not require cost sharing or matching. Eligibility is listed as unrestricted, meaning it is broadly open to different types of applicant organizations, subject to any additional eligibility clarifications in the full announcement. The opportunity was posted March 3, 2015, with an original and current closing date of April 22, 2015, and an archive date of May 22, 2015. For access issues or help with the full announcement, the listed point of contact is the CDMRP Help Desk at 301-682-5507.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the DoD Breast Cancer Breakthrough Award Levels 1 and 2, Funding Opportunity Number W81XWH 15 BCRP BREAKTHROUGH FL12. It is managed by the Department of the Army (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program.
What is the main purpose of the Breakthrough Award (Levels 1 and 2)?
The purpose is to support promising breast cancer research that has a strong chance of producing true breakthroughs rather than small, stepwise advances. The central expectation is meaningful impact: the proposed work should be positioned to significantly accelerate progress toward ending breast cancer, whether the payoff is near-term or longer-term.
What does the program mean by "breakthrough" and "impact"?
Within this mechanism, "breakthrough" and "impact" mean the work is framed around a plausible path to making a substantial difference in breast cancer outcomes. Even if a project does not include immediate clinical testing, applicants are expected to clearly explain how the research could reasonably translate into clinical impact for people who have breast cancer or who are at risk.
Does this solicitation include all Breakthrough Award levels?
No. This solicitation is focused only on Breakthrough Award Levels 1 and 2. The announcement notes that additional Breakthrough Award levels (Levels 3 and 4) exist, but those are competed under a separate opportunity.
How should an applicant choose between Funding Level 1 and Funding Level 2?
Applicants are responsible for selecting the level that matches the scope and maturity of the proposed work. The selection is intended to be driven by what the project is trying to accomplish (scope, readiness, and stage of development), not simply by how large a budget the team would like to request.
What kinds of projects are appropriate for Funding Level 1?
Funding Level 1 is intended for innovative, high-risk/high-reward ideas at the earliest stage of development. It is designed to support bold concepts and early proof-of-concept work that could open entirely new research directions.
Is preliminary data required for Funding Level 1?
No. A key feature of Funding Level 1 is that preliminary data are not required, which makes it suitable for compelling, well-justified ideas that are not yet extensively supported by existing results.
What is the expected outcome of a Funding Level 1 project?
Level 1 projects are expected to rapidly clarify whether a novel approach is viable and worth pursuing at a larger scale, generating proof-of-concept evidence that can inform next steps.
What kinds of projects are appropriate for Funding Level 2?
Funding Level 2 is for more mature research that is already supported by preliminary data. Projects at this level should be positioned to make significant advances toward clinical translation, with a clear orientation toward clinically relevant outcomes such as interventions, diagnostics, or risk reduction strategies.
Is preliminary data required for Funding Level 2?
Yes. Funding Level 2 targets research that is backed by preliminary data, reflecting that the work is beyond the earliest exploratory stage.
Does Funding Level 2 emphasize clinical translation?
Yes. Level 2 is specifically oriented toward moving closer to human impact. The work should not only be scientifically interesting, but also designed to advance toward clinically relevant outcomes.
Are in vivo model results expected for Funding Level 2?
Where relevant, applicants are expected to show efficacy in in vivo models. This reflects the program emphasis on demonstrating biological and translational credibility beyond purely exploratory or in vitro-only findings.
Can projects be small or large under this mechanism?
Yes. A major theme is that projects may range from small to large and may sit at different points along the research pipeline, as long as the application clearly frames the work around breakthrough potential and impact.
What is the Partnering PI Option?
The Partnering PI Option is a structure intended to support real, productive collaborations. Two principal investigators participate as an Initiating PI and a Partnering PI, and each PI receives a separate award.
How are responsibilities shared under the Partnering PI Option?
While the submission requirements differ for Initiating and Partnering PIs, both are expected to play substantial roles in shaping the project. They share joint responsibility for core components such as the Project Narrative and the Statement of Work.
What does the program expect applicants to explain about the partnership?
Applicants must clearly describe what each PI uniquely contributes and why the research is stronger as a coordinated partnership rather than two separate efforts. Collaborations may be within similar disciplines or across different disciplines.
Are new collaborations required for the Partnering PI Option?
No. New collaborations are welcomed but are not required.
Are there cautions against token or overly broad partnering arrangements?
Yes. The announcement discourages token or overextended partnering arrangements. It also notes that investigators should avoid being listed as a Partnering PI on multiple applications unless the projects truly address distinct questions.
Is a mentor and their current postdoctoral fellow (or junior investigator) allowed to apply together as Initiating and Partnering PIs?
The announcement explicitly states that pairing a mentor and their current postdoctoral fellow or junior investigator as Initiating and Partnering PIs does not align with the intent of the Partnering PI collaboration option.
What type of funding instrument is used (grant vs. cooperative agreement)?
This is a discretionary funding opportunity that may be offered as grants and cooperative agreements within the Science and Technology and other Research and Development activity category.
What is the CFDA number associated with this program?
The CFDA listing provided is 12.420, Military Medical Research and Development.
How many awards are anticipated and what is the estimated total funding?
The opportunity anticipates approximately 30 awards, with an estimated total funding amount of $30.8 million.
Is cost sharing or matching required?
No. The announcement indicates that cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning it is broadly open to different types of applicant organizations, subject to any additional eligibility clarifications in the full announcement.
What are the key dates for this opportunity?
The opportunity was posted on March 3, 2015. The original and current closing date is April 22, 2015. The archive date is May 22, 2015.
Who can be contacted for help accessing the full announcement or resolving access issues?
The listed point of contact is the CDMRP Help Desk at 301-682-5507.
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