Opportunity Information: Apply for W81XWH 15 BCRP BREAKTHROUGH2 FL12
Apply for W81XWH 15 BCRP BREAKTHROUGH2 FL12
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer Breakthrough Award Levels 1 and 2" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Aug 25, 2015 and posted on Aug 25, 2015.
- Applicants must submit their applications by Dec 2, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $25,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 25 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Breast Cancer Breakthrough Award Levels 1 and 2 is a U.S. Army Medical Research Acquisition Activity (USAMRAA) funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program. Its central goal is to back breast cancer research that has a genuine chance of producing a major breakthrough, not just another incremental step forward. Projects are expected to be positioned to meaningfully accelerate progress toward ending breast cancer, with impact that can be near term or longer term. A key expectation is that applicants clearly explain the pathway to clinical impact for people who have breast cancer or who are at risk for it, even if the work itself is not immediately clinical.
The program is structured around the idea that strong science is not enough on its own; it has to be impact-driven. That means the proposal should make a convincing case for why the research could shift the field in a significant way, open a new direction, or overcome an important barrier that has limited progress. The scope is intentionally flexible, allowing anything from smaller, early proof-of-concept efforts to larger projects that are further along, as long as the work matches the chosen funding level and fits the breakthrough intent.
Applicants must choose between two funding levels based on the scope and maturity of the proposed research, not simply based on how much money they want to request. Funding Level 1 is designed for innovative, high-risk/high-reward ideas that are still in the earliest stages of development. This level supports exploratory work that could create entirely new avenues of investigation and typically focuses on proof of concept. A notable feature is that preliminary data are not required, which makes this level a good fit for bold ideas that are plausible and well-argued but not yet extensively tested.
Funding Level 2 is intended for projects that are beyond the earliest idea stage and are supported by preliminary data. The expectation here is that the project is positioned to make a significant push toward clinical translation. Where it makes scientific sense, the announcement emphasizes demonstrating efficacy in in vivo models, reflecting a preference for evidence that the concept works in biologically relevant settings rather than only in simpler systems. In practice, Level 2 is meant for research that is more developed and closer to the kinds of findings that could inform future clinical studies, diagnostics, prevention strategies, or therapeutic approaches.
A distinctive feature of this opportunity is the Partnering PI Option, which is meant to encourage meaningful, productive collaborations. Under this structure, two investigators can apply together as an Initiating PI and a Partnering PI, with each PI receiving a separate award. Even though their submission requirements differ, both investigators are expected to play major roles in shaping the science and the core application components, including the project narrative and statement of work. The program is open to collaborations across similar or very different disciplines, but it requires applicants to clearly explain why the partnership is essential and why the work is better done together than as two separate efforts. While new collaborations are encouraged, they are not mandatory. At the same time, the program discourages someone from appearing as a Partnering PI on many applications unless each proposal is clearly focused on a distinct research question. It also explicitly notes that applications pairing a mentor with their current postdoctoral fellow or junior investigator as the two PIs do not fit the intent of this collaboration option.
From an administrative standpoint, the opportunity (Funding Opportunity Number W81XWH 15 BCRP BREAKTHROUGH2 FL12) is offered as discretionary federal funding through grant and cooperative agreement mechanisms under the science and technology/research and development category. The CFDA listing is 12.420 (Military Medical Research and Development). Eligibility is described as unrestricted, meaning it is broadly open to many entity types as long as applicants meet any additional eligibility details in the full announcement. The program anticipated making around 25 awards, supported by an estimated total funding pool of $25 million, and it does not require cost sharing or matching.
Key dates tied to the archived posting include an original and current closing date of December 2, 2015, with posting and creation dates of August 25, 2015, and an archive date of January 1, 2016. For help accessing the announcement, the listed contact is the CDMRP Help Desk (301-682-5507).
FAQs: DoD Breast Cancer Breakthrough Award Levels 1 and 2 (CDMRP BCRP)
What is the DoD Breast Cancer Breakthrough Award Levels 1 and 2?
It is a U.S. Army Medical Research Acquisition Activity (USAMRAA) funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program (BCRP). The award supports breast cancer research projects that have a real chance to produce a major breakthrough rather than incremental progress.
What is the main goal of this award?
The central goal is to fund impact-driven breast cancer research that can meaningfully accelerate progress toward ending breast cancer. Projects may aim for near-term or longer-term impact, but they are expected to be positioned for major advancement of the field.
What does the program mean by "breakthrough" rather than "incremental" research?
The emphasis is on proposals that could shift the field in a significant way, open a new direction, or overcome an important barrier that has limited progress. Strong science alone is not considered sufficient; the work must be clearly linked to a compelling and credible potential for major impact.
Do applicants need to describe a pathway to clinical impact?
Yes. A key expectation is that the application clearly explains the pathway to clinical impact for people who have breast cancer or who are at risk for it, even if the proposed work itself is not immediately clinical.
How flexible is the scientific scope?
The scope is intentionally flexible. The opportunity can support smaller, early proof-of-concept efforts as well as larger, more mature projects, as long as the proposal aligns with the breakthrough intent and fits the chosen funding level.
What are the two funding levels?
Applicants must choose between Funding Level 1 and Funding Level 2 based on the scope and maturity of the proposed research (not simply the amount of funding they want to request).
How should an applicant decide between Level 1 and Level 2?
The choice is expected to reflect the development stage of the science. Level 1 is for earliest-stage, innovative high-risk/high-reward concepts typically focused on proof of concept. Level 2 is for projects that are beyond the earliest idea stage and supported by preliminary data, with an expectation of meaningful movement toward clinical translation.
What is Funding Level 1 designed to support?
Funding Level 1 is designed for innovative, high-risk/high-reward ideas in the earliest stages of development. It supports exploratory work that could create entirely new avenues of investigation and typically focuses on proof of concept.
Is preliminary data required for Funding Level 1?
No. A notable feature of Funding Level 1 is that preliminary data are not required, making it suitable for bold ideas that are plausible and well-argued but not yet extensively tested.
What is Funding Level 2 designed to support?
Funding Level 2 is intended for projects that are more developed than the earliest idea stage and are supported by preliminary data. The expectation is that the research is positioned to make a significant push toward clinical translation.
Does Funding Level 2 emphasize any particular types of evidence?
Yes. Where scientifically appropriate, the opportunity emphasizes demonstrating efficacy in in vivo models, reflecting a preference for evidence in biologically relevant settings rather than only simpler systems.
What kinds of downstream impacts are envisioned for Level 2 projects?
Level 2 projects are described as being closer to findings that could inform future clinical studies, diagnostics, prevention strategies, or therapeutic approaches.
What is the Partnering PI Option?
The Partnering PI Option is a feature intended to encourage meaningful, productive collaborations. Two investigators can apply together as an Initiating PI and a Partnering PI, with each PI receiving a separate award.
How does the Partnering PI Option affect award structure?
Under this structure, there are two investigators (Initiating PI and Partnering PI), and each receives a separate award. Even if submission requirements differ between them, both are expected to play major roles in shaping the science and core application components.
Are both PIs expected to contribute to the main scientific content?
Yes. Both investigators are expected to play major roles in developing the science and the core application components, including the project narrative and statement of work.
Do partnering collaborations need to be within the same discipline?
No. The program is open to collaborations across similar or very different disciplines, as long as the applicants clearly justify why the partnership is essential.
What must be explained to justify the Partnering PI Option?
Applicants are expected to clearly explain why the partnership is essential and why the work is better done together than as two separate efforts.
Are new collaborations required to apply under the Partnering PI Option?
No. New collaborations are encouraged but are not mandatory.
Can someone serve as a Partnering PI on many applications?
The opportunity discourages someone from appearing as a Partnering PI on many applications unless each proposal is clearly focused on a distinct research question.
Are mentor-postdoc or mentor-junior investigator pairings allowed under the Partnering PI Option?
The opportunity explicitly notes that applications pairing a mentor with their current postdoctoral fellow or junior investigator as the two PIs do not fit the intent of this collaboration option.
Who offers and administers this funding opportunity?
It is a USAMRAA funding opportunity under the CDMRP Breast Cancer Research Program.
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is W81XWH 15 BCRP BREAKTHROUGH2 FL12.
What type of federal funding mechanism is used?
It is described as discretionary federal funding offered through grant and cooperative agreement mechanisms under the science and technology/research and development category.
What is the CFDA number for this opportunity?
The CFDA listing is 12.420 (Military Medical Research and Development).
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to many entity types, subject to any additional eligibility details in the full announcement.
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
How many awards were anticipated and what was the estimated total funding?
The program anticipated making around 25 awards, supported by an estimated total funding pool of $25 million.
What were the key dates for this opportunity?
The posting and creation dates listed are August 25, 2015. The original and current closing date is December 2, 2015. The archive date is January 1, 2016.
Is this opportunity still open?
Based on the provided dates, the posting is archived (archive date January 1, 2016) and the listed closing date was December 2, 2015.
Who can be contacted for help accessing the announcement?
The listed contact is the CDMRP Help Desk at 301-682-5507.
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