Opportunity Information: Apply for W81XWH 14 BCRP BREAKTHROUGH2 FL34
Apply for W81XWH 14 BCRP BREAKTHROUGH2 FL34
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer Breakthrough Award Levels 3 and 4" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Sep 3, 2014 and posted on Sep 3, 2014.
- Applicants must submit their applications by Jan 29, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $20,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Breast Cancer Breakthrough Award Levels 3 and 4 (Funding Opportunity Number W81XWH 14 BCRP BREAKTHROUGH2 FL34) is a competitive Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under CFDA 12.420 (Military Medical Research and Development). Its central purpose is to back breast cancer research that is positioned to produce true breakthroughs, meaning work that can substantially change the landscape rather than add a small, incremental step. A defining expectation is "impact": proposed projects must be framed around how they could accelerate progress toward ending breast cancer. Even when the expected benefits are longer term, applicants are required to clearly explain the pathway to real clinical impact for people who have breast cancer or who are at risk for developing it.
This announcement covers two higher-scope funding tracks, Level 3 and Level 4, which are intended for more advanced efforts than the separate Level 1 and Level 2 program announcement. Applicants are responsible for selecting the level that best fits their project scope and maturity. Level 3 is designed for advanced translational research that is close enough to the clinic to support near-term clinical investigation. This can include small-scale clinical trials, reflecting the program's intent to move strong science toward testing in patients or other clinically relevant settings. Level 4 is reserved for large-scale, ambitious projects expected to transform and potentially revolutionize the clinical management and/or prevention of breast cancer, with near-term clinical impact explicitly expected. Because of the scale and complexity, Level 4 applicants are expected to have a track record of successfully leading large, coordinated research efforts. A special review feature applies to Level 4: an invited oral presentation to the BCRP Integration Panel is required as part of application review, making the process more interactive and emphasizing the need for applicants to defend and communicate the transformative potential of the work.
Collaboration is strongly encouraged through a Partnering PI Option intended to support genuine, productive, team-based science. Under this structure, two investigators apply together as an Initiating PI and a Partnering PI, and each PI receives a separate award. While their submission requirements are not identical, both investigators are expected to play major roles in shaping and executing the project, including core sections like the project narrative and the statement of work. The program is open to collaborations between investigators with similar expertise or very different disciplines, but the application must make it obvious what distinct value each PI brings and why the work is better done as an integrated partnership rather than as two separate projects. New collaborations are welcomed but not mandatory. To keep partnerships meaningful, the solicitation discourages investigators from serving as a Partnering PI on multiple submissions unless those applications clearly address different research questions.
From an administrative standpoint, the opportunity was posted September 3, 2014, with an original and current closing date of January 29, 2015, and an archive date of February 28, 2015. The total estimated funding for the solicitation was $20,000,000, with an anticipated 7 awards. The funding instruments listed include cooperative agreements and grants, and there is no cost sharing or matching requirement. Eligibility is described as unrestricted (open to any type of entity), subject to any clarifications included in the full announcement. Applicants needing technical assistance accessing the announcement were directed to the CDMRP Help Desk (help@eBRAP.org, 301-682-5507), reflecting the program's placement within the CDMRP application and submission ecosystem.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the Department of Defense (DoD) Breast Cancer Breakthrough Award Levels 3 and 4, Funding Opportunity Number W81XWH 14 BCRP BREAKTHROUGH2 FL34. It is a competitive DoD funding program administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under CFDA 12.420 (Military Medical Research and Development).
What is the overall purpose of the Breakthrough Award (Levels 3 and 4)?
The central purpose is to support breast cancer research that is positioned to produce true breakthroughs, meaning projects that could substantially change the landscape rather than add a small, incremental advance.
What does the program mean by "impact"?
A defining expectation is impact: proposals must be framed around how the project could accelerate progress toward ending breast cancer. Even if benefits are longer term, the application is expected to clearly explain a pathway to real clinical impact for people who have breast cancer or who are at risk of developing it.
Which award levels are covered in this announcement?
This announcement covers Level 3 and Level 4 only. These are described as higher-scope tracks intended for more advanced efforts than the separate Level 1 and Level 2 program announcement.
How do applicants choose between Level 3 and Level 4?
Applicants are responsible for selecting the level that best matches the project scope and maturity. Level 3 is oriented to advanced translational work that is close enough to the clinic to support near-term clinical investigation, while Level 4 is reserved for large-scale, ambitious projects expected to transform clinical management and/or prevention with near-term clinical impact explicitly expected.
What kinds of projects fit Level 3?
Level 3 is designed for advanced translational research that is close enough to the clinic to support near-term clinical investigation. The announcement states this can include small-scale clinical trials, reflecting an intent to move strong science toward testing in patients or other clinically relevant settings.
What kinds of projects fit Level 4?
Level 4 is reserved for large-scale, ambitious projects expected to transform and potentially revolutionize the clinical management and/or prevention of breast cancer. Near-term clinical impact is explicitly expected at this level.
Are Level 4 applicants expected to have prior experience leading large research efforts?
Yes. Because of the anticipated scale and complexity of Level 4 projects, applicants are expected to have a track record of successfully leading large, coordinated research efforts.
Is there any special review requirement for Level 4 applications?
Yes. Level 4 includes a special review feature: an invited oral presentation to the BCRP Integration Panel is required as part of application review. This makes the process more interactive and emphasizes the need to clearly defend and communicate the transformative potential of the proposed work.
Is collaboration encouraged?
Yes. Collaboration is strongly encouraged through a Partnering PI Option intended to support genuine, productive, team-based science.
What is the Partnering PI Option?
Under the Partnering PI Option, two investigators apply together as an Initiating PI and a Partnering PI. Each PI receives a separate award. The structure is meant to support integrated teamwork rather than loosely connected efforts.
Do the Initiating PI and Partnering PI have identical application requirements?
No. The announcement notes that submission requirements are not identical for the two investigators. However, both are expected to play major roles in shaping and executing the project, including key components such as the project narrative and the statement of work.
Do the two PIs need to be from different disciplines?
Not necessarily. The program is open to collaborations between investigators with similar expertise or with very different disciplines. The key is that the application clearly explains the distinct value each PI brings and why the work is stronger as an integrated partnership than as two separate projects.
Are new collaborations required?
No. New collaborations are welcomed but not mandatory.
Can an investigator serve as a Partnering PI on multiple submissions?
The solicitation discourages investigators from serving as a Partnering PI on multiple submissions unless the applications clearly address different research questions. This is intended to keep partnerships meaningful.
What is the posting date for this opportunity?
The opportunity was posted on September 3, 2014.
What is the closing date?
The original and current closing date listed is January 29, 2015.
When is the archive date?
The archive date listed is February 28, 2015.
How much total funding is estimated for this solicitation?
The total estimated funding amount is $20,000,000.
How many awards are anticipated?
The solicitation anticipates 7 awards.
What types of funding instruments are expected?
The funding instruments listed include cooperative agreements and grants.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is described as unrestricted (open to any type of entity), subject to any clarifications included in the full announcement.
What CFDA number is associated with this opportunity?
This opportunity is associated with CFDA 12.420, Military Medical Research and Development.
Where can applicants get technical help accessing the announcement?
Applicants needing technical assistance accessing the announcement were directed to the CDMRP Help Desk at help@eBRAP.org or 301-682-5507.
Which organization administers the funding?
The opportunity is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) within the DoD framework described in the announcement.
What is emphasized about describing clinical relevance in the application?
The announcement emphasizes that applicants must clearly explain how the work could lead to real clinical impact for people who have breast cancer or who are at risk, even when the primary benefits are expected to occur over a longer timeframe.
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