Opportunity Information: Apply for W81XWH 13 BCRP BREAKTHROUGH
Apply for W81XWH 13 BCRP BREAKTHROUGH
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer Breakthrough Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on May 10, 2013 and posted on May 10, 2013.
- Applicants must submit their applications by Sep 25, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $75,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 50 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Breast Cancer Breakthrough Award (BCRP Breakthrough Award) is a FY13 funding opportunity from the U.S. Army Medical Research Acquisition Activity under the Congressionally Directed Medical Research Programs, created to back breast cancer research with real breakthrough potential. It was introduced for the first time in FY13 with a clear emphasis on impact, meaning the proposed work needs to aim for a major leap forward rather than a small, incremental improvement. Applicants are expected to spell out a believable pathway to how the research could meaningfully benefit breast cancer patients, even if the work is still at a stage where immediate clinical impact is not expected. The central idea is to accelerate progress toward ending breast cancer by supporting projects that can change what researchers understand, how clinicians treat, or how patients ultimately fare.
A defining feature of this opportunity is its tiered structure, which is designed to accommodate a wide range of project sizes and maturity levels, from early concept exploration to large clinical efforts. Investigators choose among four funding levels based on how developed the idea is and how close it is to translation or clinical use. Funding Level 1 is geared toward innovative, high-risk/high-reward concepts that are still in the earliest phases of development, where proof-of-concept is the main goal and preliminary data are not required. This level is meant to open new directions and encourage bold ideas that may be too early for more traditional funding mechanisms. Funding Level 2 supports projects that already have preliminary data and are positioned to make meaningful advances toward moving discoveries from the lab toward the clinic, with expectations such as demonstrating efficacy in relevant in vivo models when applicable. Funding Level 3 targets advanced translational research with a realistic path into near-term clinical investigation; small-scale clinical trials can fit here, reflecting a stronger push toward patient-facing evaluation. Funding Level 4 is reserved for large-scale, ambitious projects intended to transform and potentially revolutionize clinical management of breast cancer, where near-term clinical impact is anticipated and the principal investigator is expected to have a track record leading large, complex efforts.
The overall solicitation lists an estimated total funding amount of $75,000,000 and an expected 50 awards, offered through grants and cooperative agreements under the Science and Technology and other Research and Development activity category (CFDA 12.420, Military Medical Research and Development). Eligibility is broadly described as unrestricted, meaning it is open to a wide range of applicant organizations, subject to any additional eligibility clarifications in the full announcement. Cost sharing or matching is not required, lowering barriers for applicants who may not have access to substantial non-federal funds. The opportunity (Funding Opportunity Number W81XWH 13 BCRP BREAKTHROUGH) was posted May 10, 2013, with an application closing date of September 25, 2013, and an archive date of October 25, 2013.
One special review-related requirement applies to the highest tier: for Funding Level 4, an invited oral presentation to the BCRP Integration Panel is required as part of application review. This reflects the scale and clinical stakes of Level 4 proposals and signals that these projects receive additional scrutiny and discussion beyond written materials alone. For assistance accessing the announcement, the point of contact provided is the CDMRP Help Desk (301-682-5507, help@cdmrp.org).
FAQs: DoD Breast Cancer Breakthrough Award (BCRP Breakthrough Award, FY13)
What is the DoD Breast Cancer Breakthrough Award?
The DoD Breast Cancer Breakthrough Award (also called the BCRP Breakthrough Award) is an FY13 funding opportunity created under the Congressionally Directed Medical Research Programs (CDMRP) and managed by the U.S. Army Medical Research Acquisition Activity. It is intended to support breast cancer research projects with genuine breakthrough potential.
What is the main goal of this funding opportunity?
The central aim is impact: proposals should pursue a major leap forward in breast cancer research or care, rather than a small, incremental improvement. The program is designed to accelerate progress toward ending breast cancer by supporting projects that can change what researchers understand, how clinicians treat, or how patients ultimately fare.
What does the program mean by “breakthrough potential†and “impact�
“Breakthrough potential†and “impact†mean the work should be positioned to produce a substantial advance. Applicants are expected to describe a believable pathway showing how the research could meaningfully benefit breast cancer patients, even if immediate clinical impact is not expected because the work is still at an earlier stage.
When was the Breakthrough Award introduced?
This award mechanism was introduced for the first time in FY13.
How is the award structured?
The opportunity uses a tiered structure with four funding levels. Investigators select the funding level that best matches how mature the idea is and how close it is to translation or clinical use. The tiers range from early concept exploration through large clinical efforts.
What is Funding Level 1 intended to support?
Funding Level 1 is aimed at innovative, high-risk/high-reward concepts in the earliest phases of development. The emphasis is on proof-of-concept, and preliminary data are not required. This level is meant to encourage bold ideas that may be too early for traditional funding mechanisms.
Does Funding Level 1 require preliminary data?
No. Funding Level 1 does not require preliminary data and is focused on proof-of-concept for early, innovative ideas.
What is Funding Level 2 intended to support?
Funding Level 2 supports projects that already have preliminary data and are positioned to make meaningful advances toward moving discoveries from the lab toward the clinic. Expectations include demonstrating efficacy in relevant in vivo models when applicable.
What kinds of evidence or expectations are mentioned for Funding Level 2?
The solicitation notes that Funding Level 2 projects are expected to have preliminary data, and when applicable, to demonstrate efficacy in relevant in vivo models as part of advancing toward translation.
What is Funding Level 3 intended to support?
Funding Level 3 targets advanced translational research with a realistic path into near-term clinical investigation. Small-scale clinical trials may be appropriate at this level, reflecting a stronger push toward patient-facing evaluation.
Are clinical trials allowed under this opportunity?
Yes. The solicitation indicates that small-scale clinical trials can fit under Funding Level 3, and Funding Level 4 is designed for large-scale projects with near-term clinical impact anticipated.
What is Funding Level 4 intended to support?
Funding Level 4 is reserved for large-scale, ambitious projects intended to transform and potentially revolutionize clinical management of breast cancer. Near-term clinical impact is anticipated, and the principal investigator is expected to have a track record leading large, complex efforts.
Is there any special review requirement for Funding Level 4?
Yes. For Funding Level 4, an invited oral presentation to the BCRP Integration Panel is required as part of application review. This is in addition to written review materials and reflects the scale and clinical stakes of Level 4 proposals.
How much total funding is estimated for this solicitation?
The solicitation lists an estimated total funding amount of $75,000,000.
How many awards are expected?
The solicitation indicates an expected 50 awards.
What types of funding instruments are used?
Awards are offered through grants and cooperative agreements.
What is the Funding Opportunity Number?
The Funding Opportunity Number is W81XWH 13 BCRP BREAKTHROUGH.
Which federal program/category is associated with this opportunity?
The activity category is listed as Science and Technology and other Research and Development, with CFDA 12.420 (Military Medical Research and Development).
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is open to a wide range of applicant organizations, subject to any additional eligibility clarifications in the full announcement.
Is cost sharing or matching required?
No. Cost sharing or matching is not required for this opportunity.
When was the opportunity posted?
The opportunity was posted on May 10, 2013.
What was the application closing date?
The application closing date was September 25, 2013.
When was the opportunity archived?
The archive date was October 25, 2013.
Who can applicants contact for help accessing the announcement?
The point of contact listed for assistance is the CDMRP Help Desk at 301-682-5507 or help@cdmrp.org.
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