Opportunity Information: Apply for W81XWH 16 BCRP DIA

  • The DOD-AMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Breast Cancer Distinguished Investigator Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on Mar 01, 2016 and posted on Mar 01, 2016.
  • Applicants must submit their applications by Aug 11, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 16 BCRP DIA

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Opportunity Summary:

The DOD Breast Cancer Research Program (BCRP) Distinguished Investigator Award is designed to support well-established, highly respected scientific leaders who can bring bold, unconventional thinking to breast cancer research. The program is aimed at principal investigators who are widely recognized for groundbreaking contributions in their own fields and who have a clear track record of high-impact discovery, strong productivity, and the ability to build and lead effective collaborations. In short, the award is meant for researchers with the stature and vision to make unusually significant advances toward the goal of ending breast cancer.

A defining requirement of this opportunity is that the proposed project must represent a fundamental departure from the PI's prior published research trajectory. The intent is not to fund a continuation of existing work or an incremental next step; instead, the application must propose a genuine shift in direction that tackles at least one of the BCRP overarching challenges. The award is positioned to encourage high-risk, high-reward concepts, and it allows for limited preliminary data. Even so, applicants must still present a well-constructed, testable hypothesis grounded in a strong scientific rationale, meaning the work should be ambitious but not speculative to the point of being untestable.

Importantly, the program does not require prior experience in breast cancer research. Investigators from other disciplines are explicitly encouraged to apply if they can bring novel tools, concepts, or perspectives that could change the breast cancer landscape. However, the project itself must be clearly focused on breast cancer. If the PI is not already a breast cancer researcher, the research team must include at least one collaborator with breast cancer expertise to ensure the work is scientifically and clinically grounded in the realities of the disease.

The award also places a strong emphasis on meaningful engagement with the breast cancer community through required consumer advocacy participation. Each application must include two or more breast cancer consumer advocates who have personally been diagnosed with breast cancer and who are actively involved in a breast cancer advocacy organization. These advocates must serve as independent, lay representatives and cannot be employees of any organization participating in the application. They are expected to have enough knowledge of current breast cancer issues and sufficient training or background in research to provide informed feedback. Their role is to offer objective input on the project, particularly regarding relevance, patient-centered impact, and the potential significance for individuals living with breast cancer or those at risk.

From an administrative and funding standpoint, this opportunity was issued by DOD-AMRAA under Funding Opportunity Number W81XWH-16-BCRP-DIA and falls under CFDA 12.420 for science and technology research and development. The funding instrument type allows for either a grant or a cooperative agreement, indicating that awards may involve varying levels of government involvement depending on the project structure. Eligibility is described as unrestricted, meaning it is broadly open to many entity types, subject to any additional eligibility clarifications in the full announcement. The original and current closing date listed for this cycle was August 11, 2016, with an expected two awards and an award ceiling not specified in the provided source details.

Frequently Asked Questions (FAQs)

What is the DOD Breast Cancer Research Program (BCRP) Distinguished Investigator Award?

The Distinguished Investigator Award is a funding opportunity intended to support well-established, highly respected scientific leaders who can bring bold, unconventional thinking to breast cancer research. It is positioned for principal investigators (PIs) with a strong record of high-impact discovery, high productivity, and the ability to build and lead effective collaborations, with the goal of making unusually significant advances toward ending breast cancer.

Who is this award intended for?

This award is intended for widely recognized scientific leaders (PIs) with a demonstrated track record of groundbreaking contributions in their own fields, strong productivity, and proven leadership in collaborative research. The focus is on investigators with the stature and vision to pursue high-risk, high-reward ideas that could meaningfully change the breast cancer landscape.

Does the proposed project need to be different from the PI's previous research?

Yes. A defining requirement is that the project must represent a fundamental departure from the PI's prior published research trajectory. The intent is to fund a genuine shift in direction rather than a continuation of existing work or an incremental next step.

Are incremental or continuation projects allowed?

No. The opportunity is specifically intended to avoid funding incremental extensions of prior work. The application should propose a clear, substantive change in research direction that is distinct from the PI's previous published trajectory.

What kinds of research concepts does this award encourage?

The award is designed to encourage high-risk, high-reward concepts and bold, unconventional approaches. While limited preliminary data are allowed, the proposed work must still be scientifically grounded and testable.

Is preliminary data required?

The program allows for limited preliminary data. Even with limited preliminary data, the application must present a well-constructed, testable hypothesis supported by a strong scientific rationale.

How speculative can the proposed research be?

The research can be ambitious and high-risk, but it should not be speculative to the point of being untestable. Applicants must still provide a testable hypothesis and strong scientific rationale.

Does the project have to address specific program goals?

Yes. The project must tackle at least one of the BCRP overarching challenges (as referenced in the opportunity description). The proposed shift in direction should clearly connect to those broader program challenges.

Do applicants need prior experience in breast cancer research?

No. Prior breast cancer research experience is not required. Investigators from other disciplines are explicitly encouraged to apply if they can bring novel tools, concepts, or perspectives that could change the breast cancer landscape.

If the PI is not a breast cancer researcher, are collaborators required?

Yes. If the PI is not already a breast cancer researcher, the research team must include at least one collaborator with breast cancer expertise to ensure the work is scientifically and clinically grounded in the realities of the disease.

Does the proposed work still have to be focused on breast cancer?

Yes. Even if the PI comes from another field, the project itself must be clearly focused on breast cancer.

Is consumer advocacy participation required?

Yes. Meaningful engagement with the breast cancer community is a required element of this opportunity through consumer advocacy participation.

How many consumer advocates are required in the application?

Each application must include two or more breast cancer consumer advocates.

Who qualifies as a consumer advocate for this award?

Consumer advocates must have personally been diagnosed with breast cancer and be actively involved in a breast cancer advocacy organization. They are expected to serve as independent, lay representatives who can provide informed feedback based on knowledge of current breast cancer issues and sufficient training or background in research.

Can consumer advocates be employees of participating organizations?

No. The consumer advocates cannot be employees of any organization participating in the application.

What is the role of consumer advocates on the project?

They provide objective, lay input on the project, particularly around relevance, patient-centered impact, and potential significance for individuals living with breast cancer or those at risk.

What is the Funding Opportunity Number for this award?

The Funding Opportunity Number (FON) is W81XWH-16-BCRP-DIA.

Which agency issued this opportunity?

This opportunity was issued by DOD-AMRAA.

What is the CFDA number associated with this opportunity?

The opportunity falls under CFDA 12.420, categorized as science and technology research and development.

What type of funding instrument is used (grant or cooperative agreement)?

The opportunity allows for either a grant or a cooperative agreement. This indicates awards may involve varying levels of government involvement depending on the project structure.

Who is eligible to apply?

Eligibility is described as unrestricted, meaning it is broadly open to many entity types, subject to any additional eligibility clarifications in the full announcement.

What was the application closing date listed for this cycle?

The original and current closing date listed for this cycle was August 11, 2016.

How many awards were expected for this cycle?

The opportunity listed an expectation of two awards.

What is the award ceiling (maximum funding amount)?

The award ceiling was not specified in the provided details.

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