DoD Breast Cancer Idea Award | Apply Online

Opportunity Summary:

The DoD Breast Cancer Research Program (BCRP) Idea Award (Funding Opportunity Number W81XWH-11-BCRP-IDEA) is a FY2011 discretionary funding opportunity from the Department of the Army, administered through USAMRAA, intended to push breast cancer research in bold directions that can open up new lines of investigation. The central purpose of the mechanism is to support promising, hypothesis-driven projects with an unusually strong chance of producing highly impactful data, even when the work carries more scientific risk than traditional incremental studies. The program is explicitly framed around accelerating major advances toward the eradication of breast cancer, so applicants are expected to make a clear case that their approach could change what is possible in the field rather than simply add another small piece of evidence.

This mechanism places the greatest emphasis on Impact and Innovation. Impact, in this context, means the project has credible potential to drive major advancements and meaningfully speed progress against breast cancer, such as enabling new prevention strategies, improving detection, transforming treatment approaches, or revealing important biological mechanisms that could redirect the field. Innovation refers to research that is conceptually original, such as introducing a new paradigm, challenging prevailing assumptions, reframing existing problems, or applying uniquely creative thinking or methods. Importantly, the solicitation notes that while innovation is highly valued, a proposal that is not especially innovative can still fit the award if it convincingly offers high potential impact. Regardless of where a project falls on the innovation spectrum, the Principal Investigator is responsible for explicitly explaining both the expected impact on breast cancer and what makes the work innovative (or, if not strongly innovative, why the likely impact is still extraordinary).

The funding opportunity allows preliminary data but does not require it, which signals openness to earlier-stage ideas as long as they are grounded in a strong scientific rationale and presented with a well-formulated, testable hypothesis. In other words, applicants do not need to have extensive pilot results in hand, but they do need to demonstrate that the proposed work is logically constructed, scientifically defensible, and designed to produce interpretable outcomes that can meaningfully move the field forward.

A notable feature is the Partnering PI Option, which is meant to encourage real, productive collaborations between two investigators. Under this structure, there are two PIs (an Initiating PI and a Partnering PI), and each PI is supported under a separate award, but both contribute to the development of a single, unified application. The intent is to bring together complementary strengths, whether from similar areas or very different disciplines, in a way that makes the combined effort more powerful than two parallel projects would be. Applicants using this option must clearly explain how the partnership improves the ability to answer the research question and why the work should be done together rather than split into separate efforts. New collaborations are welcomed but not mandatory. The announcement also clarifies a boundary for eligibility under this collaboration model: applications pairing a mentor and a postdoctoral trainee as the two PIs do not meet the intent of the Partnering PI Option.

From an administrative standpoint, this opportunity used grant and cooperative agreement funding instruments under the Science and Technology and other Research and Development activity category. The program anticipated about 10 awards with an estimated total funding level of $7.5 million, and it did not require cost sharing or matching. Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications in the full text of the announcement. The opportunity was posted April 19, 2011, with an original and final closing date of August 25, 2011, and an archive date of September 24, 2011. The CFDA listing associated with the program is 12.420 (Military Medical Research and Development). For applicant support, the announcement provides contact points for program announcement access issues and for electronic submission help through the CDMRP help desk channels.

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