DoD Defense Medical Research and Development Program Basic Research Award | Apply Online

Opportunity Summary:

The DoD Defense Medical Research and Development Program (DMRDP) Basic Research Award is a U.S. Army-managed funding opportunity (USAMRAA) intended to support early-stage, conceptually innovative basic research that increases fundamental scientific and medical understanding. The emphasis is on high risk/high reward ideas that may be too new for extensive preliminary results, but that have clear potential to generate impactful data, open new research directions, and ultimately drive major advances relevant to military medicine. The program frames "basic research" in the classic sense: work aimed at uncovering underlying principles and mechanisms rather than demonstrating an immediately deployable product, while still keeping an eye on downstream relevance to military health needs.

A central goal of the award is to accelerate breakthroughs that could improve protection, diagnosis, and treatment for health threats faced in military operational environments. This includes research that could someday enable new medical countermeasures, better clinical approaches for injured or ill service members, and stronger evidence foundations for preventing or mitigating mission-related health risks. In addition to discovery-oriented biomedical science, the announcement also highlights support for basic research that can enhance training and education for military personnel and health care providers, recognizing that readiness depends not only on technologies and therapies but also on how effectively people are trained to apply medical knowledge in demanding settings.

Preliminary data are not required, which is a notable feature for investigators proposing bold, untested concepts. That said, competitiveness still depends on rigorous scientific thinking. Applicants are expected to present a well-formed, testable hypothesis and back it with a sound rationale grounded in a critical, well-reasoned analysis of existing literature. In practical terms, the program is signaling that it will consider early ideas, but only if the proposal demonstrates clear logic, strong command of the field, and a credible plan to answer an important foundational question.

From an administrative standpoint, awards under this announcement are issued only as assistance agreements, specifically grants and cooperative agreements, under the broader category of science and technology and research and development. The opportunity is explicitly targeted to extramural investigators, meaning applicants who are not Department of Defense employees working within DoD laboratories or military medical treatment facilities, and not part of a DoD activity embedded within a civilian medical center. Intramural DoD researchers are directed to separate announcements.

Key details from the posted opportunity include a Funding Opportunity Number of W81XWH 10 DMRDP BRA and a CFDA listing under 12.420 (Military Medical Research and Development). The program projected up to about 50 awards, with an estimated total funding level of $60,000,000, and it indicated no cost sharing or matching requirement. Eligibility was listed as unrestricted (open to any entity type), subject to any additional clarifications in the full text of the announcement. The opportunity was originally posted in November 2009, created in February 2010, and had a closing date in February 2010 that was extended to February 24, 2010 due to inclement weather, with an archive date in March 2010. For applicant support, the announcement provided help contacts for accessing the announcement and for electronic submission troubleshooting through the CDMRP help channels.

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