Opportunity Information: Apply for W81XWH 13 DMDRP IIRA
Apply for W81XWH 13 DMDRP IIRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Duchenne Muscular Dystrophy Investigator Initiated Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Jun 6, 2013 and posted on Jun 6, 2013.
- Applicants must submit their applications by Nov 6, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,020,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Duchenne Muscular Dystrophy Research Program (DMDRP) Investigator Initiated Research Award (IIRA) is a Department of the Army (USAMRAA) funding opportunity meant to push promising Duchenne muscular dystrophy (DMD) ideas closer to real-world patient impact. It is specifically aimed at translational research, meaning work that deliberately connects basic science findings and clinical observations with the practical goal of developing or improving therapies. The program emphasizes that translation is not a one-way path from lab to clinic; it is a continuous back-and-forth where clinical insights shape lab experiments and lab results inform clinical decision-making. Within that bench-to-bedside continuum, this award focuses on mid-stage to later-stage translation, not early discovery research.
The types of projects the IIRA is designed to support include preclinical studies in relevant animal models and studies involving human subjects or human anatomical substances, as well as early-phase, proof-of-principle clinical trials. It also supports correlative studies that can clarify or validate signals relevant to the development of drugs, devices, and other interventions for DMD, such as biomarker work tied to treatment response or disease progression. A key expectation is that proposed studies are built on a foundation of preliminary data that directly relates to DMD and supports the feasibility of the proposed approach. In other words, applicants are expected to show they are not starting from scratch and that the work is ready for a translational push rather than initial exploration.
A major requirement of the award is rigorous study design and transparent reporting. The announcement points applicants to widely recognized reporting standards (described in a Nature article) and highlights core practices such as randomization, blinding, sample size estimation, and clear plans for data handling. Although those standards are often discussed in the context of preclinical research, the program makes it clear that the same principles reflect established best practices in clinical research and should also be applied where relevant in human studies. The overall message is that the DoD wants proposals that will produce credible, reproducible results that can genuinely support the next step toward clinical adoption.
Just as important as what the IIRA supports is what it does not support. The award mechanism excludes several categories typically associated with earlier-stage discovery science, including target discovery, broad drug screening, mechanism-of-action studies, and purely hypothesis-driven pathophysiology research. This boundary reinforces the program’s purpose: funding work that is already positioned to advance an intervention or an intervention-enabling strategy, rather than work aimed primarily at uncovering new biological targets or explaining disease mechanisms in a general sense.
Collaboration is strongly encouraged, though not strictly required. The program particularly values partnerships that bridge laboratory and clinical expertise, as well as collaborations between academia and biotechnology or pharmaceutical industry scientists. It also welcomes teams that bring in new disciplinary perspectives or introduce new investigators to the DMD field, reflecting an interest in cross-pollination and practical development expertise that can speed translation.
Administratively, this opportunity is listed under Funding Opportunity Number W81XWH 13 DMDRP IIRA and uses a cooperative agreement/grant structure within the science and technology and research and development category. It was posted June 6, 2013, with an original and current closing date of November 6, 2013, and an archive date of December 6, 2013. The program anticipated making about two awards with an estimated total funding level of $2,020,000 and reported no cost sharing or matching requirement. Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement. The CFDA listing referenced is 12.420 (Military Medical Research and Development). For access issues or announcement-related help, the contact provided is the CDMRP Help Desk (301-682-5507, help@cdmrp.org).
FAQs: DoD Duchenne Muscular Dystrophy Research Program (DMDRP) - Investigator Initiated Research Award (IIRA)
What is the DMDRP Investigator Initiated Research Award (IIRA)?
The DMDRP IIRA is a Department of the Army (USAMRAA) funding opportunity intended to move promising Duchenne muscular dystrophy (DMD) research ideas closer to real-world patient impact. It is designed for translational research with a practical focus on developing or improving therapies or other interventions for DMD.
What is the main goal of this award?
The main goal is to support mid-stage to later-stage translational work that deliberately connects basic science and clinical observations with the practical next steps needed to advance DMD interventions toward patient use.
Is this award intended for early discovery research?
No. This award focuses on mid-stage to later-stage translation rather than early discovery research.
How does the program describe "translational research"?
The program emphasizes that translation is a continuous bench-to-bedside-and-back process: clinical insights should inform laboratory experiments, and laboratory findings should inform clinical decision-making. The IIRA is positioned within that continuum to fund research closer to application and impact.
What types of studies are supported under this award?
Supported project types include preclinical studies in relevant animal models, studies involving human subjects or human anatomical substances, early-phase proof-of-principle clinical trials, and correlative studies that clarify or validate signals relevant to the development of drugs, devices, or other interventions for DMD (including biomarker efforts tied to treatment response or disease progression).
Does the IIRA support clinical trials?
Yes. The opportunity includes support for early-phase, proof-of-principle clinical trials, based on the description provided.
Does the IIRA support preclinical animal studies?
Yes. The IIRA is designed to support preclinical studies conducted in relevant animal models.
Are studies with human subjects or human anatomical substances allowed?
Yes. The program description includes studies involving human subjects or human anatomical substances.
What are "correlative studies" in the context of this award?
Correlative studies are described as studies that clarify or validate signals relevant to developing DMD interventions. Examples mentioned include biomarker work tied to treatment response or disease progression.
Is preliminary data required?
Yes. A key expectation is that proposals are supported by preliminary data directly related to DMD and demonstrating the feasibility of the proposed translational approach. The intent is that applicants are not starting from scratch and are ready for a translational push.
What does the program emphasize about study design and reporting?
The award requires rigorous study design and transparent reporting to support credible and reproducible results. The announcement points applicants to widely recognized reporting standards (noted as being described in a Nature article) and highlights core practices such as randomization, blinding, sample size estimation, and clear data handling plans.
Are the rigorous design principles only for preclinical work?
No. While the standards are often discussed for preclinical research, the program indicates that the same principles represent established best practices in clinical research and should be applied where relevant in human studies as well.
What kinds of projects are explicitly not supported?
The award mechanism excludes several categories typically associated with earlier-stage discovery science, including target discovery, broad drug screening, mechanism-of-action studies, and purely hypothesis-driven pathophysiology research.
Does the program fund mechanism-of-action studies?
No. Mechanism-of-action studies are listed among the categories excluded under this award mechanism.
Does the program fund target discovery or broad drug screening?
No. Target discovery and broad drug screening are specifically listed as excluded categories.
Does the program fund purely hypothesis-driven pathophysiology research?
No. Purely hypothesis-driven pathophysiology research is excluded as described in the opportunity summary.
Is collaboration required?
Collaboration is strongly encouraged but not described as strictly required.
What types of collaborations does the program value?
The program particularly values collaborations that bridge laboratory and clinical expertise, partnerships between academia and biotechnology or pharmaceutical industry scientists, and teams that bring new disciplinary perspectives or introduce new investigators to the DMD field.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number listed is W81XWH 13 DMDRP IIRA.
What agency or administrative organization is associated with this opportunity?
The opportunity is described as a Department of the Army (USAMRAA) funding opportunity within the DoD Duchenne Muscular Dystrophy Research Program (DMDRP).
What award or funding structure is used?
It uses a cooperative agreement/grant structure and is categorized under science and technology and research and development.
When was this funding opportunity posted?
The posting date provided is June 6, 2013.
What was the closing date?
The original and current closing date provided is November 6, 2013.
When was the opportunity archived?
The archive date provided is December 6, 2013.
How many awards were anticipated?
The program anticipated making about two awards.
What was the estimated total funding level?
The estimated total funding level reported is $2,020,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement.
What CFDA number is referenced for this opportunity?
The CFDA listing referenced is 12.420 (Military Medical Research and Development).
Who can applicants contact for access issues or help with the announcement?
The contact provided is the CDMRP Help Desk at 301-682-5507 or help@cdmrp.org.
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