Opportunity Information: Apply for W81XWH 14 DMDRP TIA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Duchenne Muscular Dystrophy Therapeutic Idea Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on May 27, 2014 and posted on May 27, 2014.
  • Applicants must submit their applications by Oct 22, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $480,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:

The DoD Duchenne Muscular Dystrophy Therapeutic Idea Award (TIA) is a Department of Defense funding opportunity under the Duchenne Muscular Dystrophy Research Program (DMDRP) that focuses on pushing forward brand-new therapeutic concepts for Duchenne muscular dystrophy (DMD), especially ideas that are still early and not yet heavily supported by extensive prior results. It is intended to generate high-impact data that can open up fresh directions for DMD treatment research, with an emphasis on novel therapeutics rather than incremental extensions of established approaches. The mechanism explicitly favors conceptually innovative projects that carry a high risk but also the potential for a high reward, meaning applicants are encouraged to propose bold, well-justified ideas that could realistically lead to major breakthroughs or meaningful advances in DMD therapeutics if successful.

A central feature of this award is that proposals must be driven by a well-formulated, testable hypothesis supported by strong scientific rationale. In other words, even though the work can be exploratory and early stage, it still needs to be anchored in clear biological or therapeutic reasoning and laid out in a way that can be evaluated through defined experiments. The program also signals that extensive preliminary data is not the goal of this mechanism. While applicants are not banned from including preliminary findings, reviewers are instructed, in effect, to evaluate applications based on the innovation, logic, and potential impact of the idea rather than the depth of existing supportive data. This design is meant to lower the barrier for investigators who have compelling therapeutic concepts but are not yet at a stage where they can present a large body of preliminary results.

Administratively, this opportunity was issued as Funding Opportunity Number W81XWH-14-DMDRP-TIA, titled "DoD Duchenne Muscular Dystrophy Therapeutic Idea Award." It falls under the Department of the Army, administered through USAMRAA, and is categorized under science and technology and other research and development. The funding instrument type allows for either a cooperative agreement or a grant. The total estimated funding listed for the opportunity is $480,000, with an expectation of making 1 award, and there is no cost sharing or matching requirement. The CFDA listing associated with the program is 12.420 (Military Medical Research and Development). Eligibility is described as unrestricted, meaning it is broadly open to applicants of any entity type, subject to any additional eligibility clarifications contained in the full announcement text.

Key dates for this specific cycle include a posted and creation date of May 27, 2014, with an original and current closing date of October 22, 2014, and an archive date of November 21, 2014. For technical issues accessing the full announcement, the point of contact provided is the CDMRP Help Desk (phone: 301-682-5507; email: help@eBRAP.org).

DoD Duchenne Muscular Dystrophy Therapeutic Idea Award (TIA) FAQs

What is the DoD Duchenne Muscular Dystrophy Therapeutic Idea Award (TIA)?

The Therapeutic Idea Award (TIA) is a Department of Defense funding opportunity under the Duchenne Muscular Dystrophy Research Program (DMDRP). It is designed to push forward brand-new therapeutic concepts for Duchenne muscular dystrophy (DMD), particularly early-stage ideas that are not yet heavily supported by extensive prior results.

What is the main goal of this award mechanism?

The main goal is to generate high-impact data that can open up fresh directions for DMD treatment research. The program emphasizes novel therapeutics rather than incremental extensions of established approaches.

What types of projects are favored by this opportunity?

This mechanism explicitly favors conceptually innovative projects that carry high risk but also the potential for high reward. Applicants are encouraged to propose bold, well-justified ideas that could realistically lead to major breakthroughs or meaningful advances in DMD therapeutics if successful.

Is the award intended for incremental research or extensions of existing approaches?

No. The emphasis is on novel therapeutics and brand-new therapeutic concepts, not incremental extensions of established approaches.

Does the proposal need a hypothesis?

Yes. Proposals must be driven by a well-formulated, testable hypothesis that is supported by strong scientific rationale. Even though the work can be exploratory and early stage, it still needs to be anchored in clear biological or therapeutic reasoning and laid out so it can be evaluated through defined experiments.

Do applicants need extensive preliminary data to be competitive?

No. Extensive preliminary data is not the goal of this mechanism. While applicants are not prohibited from including preliminary findings, reviewers are expected to evaluate applications based on the innovation, logic, and potential impact of the idea rather than the depth of existing supportive data.

What does "high risk, high reward" mean in the context of this award?

It means the program encourages proposals that may be early and exploratory (and therefore carry more uncertainty), as long as they are bold, well-justified, and have the potential to produce major breakthroughs or meaningful advances in DMD therapeutics if successful.

What is the Funding Opportunity Number for this announcement?

The Funding Opportunity Number is W81XWH-14-DMDRP-TIA.

What is the official title of the opportunity?

The official title is "DoD Duchenne Muscular Dystrophy Therapeutic Idea Award."

Which agency and office administer this funding opportunity?

The opportunity falls under the Department of the Army and is administered through USAMRAA.

What type of funding instrument is used?

The funding instrument type allows for either a cooperative agreement or a grant.

How much total funding is estimated for this opportunity?

The total estimated funding listed for the opportunity is $480,000.

How many awards are expected to be made?

The opportunity indicates an expectation of making 1 award.

Is cost sharing or matching required?

No. There is no cost sharing or matching requirement listed for this opportunity.

What is the CFDA number associated with this program?

The CFDA listing associated with the program is 12.420 (Military Medical Research and Development).

Who is eligible to apply?

Eligibility is described as unrestricted, meaning it is broadly open to applicants of any entity type, subject to any additional eligibility clarifications contained in the full announcement text.

What category does this opportunity fall under?

It is categorized under science and technology and other research and development.

When was this opportunity posted?

The posted (and creation) date listed for this cycle is May 27, 2014.

What was the application closing date?

The original and current closing date listed is October 22, 2014.

When was this opportunity archived?

The archive date is November 21, 2014.

Who should applicants contact for technical issues accessing the full announcement?

For technical issues accessing the full announcement, the point of contact provided is the CDMRP Help Desk: phone 301-682-5507, email help@eBRAP.org.

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