Opportunity Information: Apply for W81XWH 11 PCRP SIDA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD FY11 Prostate Cancer Synergistic Idea Development Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Apr 21, 2011 and posted on Apr 21, 2011.
  • Applicants must submit their applications by Aug 23, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $8,400,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 7 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 11 PCRP SIDA

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Opportunity Summary:

The DoD FY11 Prostate Cancer Synergistic Idea Development Award (SIDA), offered through the Congressionally Directed Medical Research Programs (CDMRP) Prostate Cancer Research Program (PCRP), is a cooperative agreement/grant opportunity intended to speed up meaningful progress in prostate cancer research by funding highly innovative, team-based projects. The program is built around the idea that some of the most impactful advances come from true collaboration, where different disciplines and viewpoints are combined to tackle a shared scientific problem in a way that a single lab could not accomplish alone. Since the mechanism began in FY07, it attracted 260 proposed projects, with 26 projects (57 individual awards) recommended for funding, which signals that it is competitive and focused on standout concepts.

The core requirement is that the project must be jointly designed and carried out by two or three independent, faculty-level (or equivalent) Principal Investigators. These investigators are expected to bring complementary expertise and to demonstrate real synergy, meaning the proposal should clearly explain what each PI uniquely contributes and how the combined approach accelerates progress beyond what would be possible through separate, parallel efforts. Multidisciplinary and multi-institution collaborations are welcomed, but the application must spell out how the team will function in practice, including how they will communicate, coordinate work, share data, and manage project integration across sites. For multi-institution teams, the announcement also requires an intellectual property plan to proactively address ownership and sharing of intellectual and material property and to prevent institutional policies from becoming barriers to collaboration.

In terms of scientific scope, the award supports new ideas and innovative approaches across the full range of prostate cancer research, from basic science through clinical research, but with an important boundary: human subjects research is allowed only if it does not involve a clinical trial. The announcement defines a clinical trial as prospective enrollment of human subjects where an intervention (such as a drug, device, biologic, surgery, behavioral intervention, or similar) is tested for measurable outcomes related to safety, effectiveness, efficacy, or other direct effects of that intervention on the participant. Applicants who want to run a clinical trial are directed instead to the FY11 PCRP Clinical Trial Award. Similarly, investigators planning population-based studies are encouraged to consider the FY11 PCRP Population Based Research Award rather than this mechanism.

The program emphasizes innovation and accepts that higher-risk ideas can be part of groundbreaking work, but it still expects proposals to be anchored in a sound scientific rationale supported by logical reasoning and/or a critical analysis of the existing literature. Preliminary data relevant to prostate cancer is encouraged but not required, reflecting the mechanism's goal of enabling novel directions that may not yet have extensive pilot results. If preliminary data are included, they should come from the participating PIs or members of the collaborating team.

Applicants are strongly encouraged to align their projects with one of the FY11 PCRP overarching challenges. If a proposed project does not directly address one of those challenges, the application must make a clear case for why it still meets a critical need in prostate cancer research and/or patient care. This reflects the program's broader mission to accelerate advances that support the PCRP vision of conquering prostate cancer, while still allowing room for compelling ideas that may fall outside predefined thematic areas if they convincingly address an unmet need.

From an administrative and funding standpoint, this opportunity was posted April 21, 2011, with an original and current closing date of August 23, 2011, and an archive date of September 22, 2011. It is identified by Funding Opportunity Number W81XWH-11-PCRP-SIDA and CFDA 12.420 (Military Medical Research and Development). The agency is the Department of the Army (USAMRAA). The estimated total funding was $8.4 million, with an expected 7 awards, and there is no cost sharing or matching requirement. Eligibility is listed as unrestricted (open to any entity type), subject to any additional eligibility clarifications in the full announcement. A notable structural feature is that although the collaborators jointly develop a single integrated project, each partner is formally recognized as a PI, submits a separate application, and receives an individual award, which reinforces the expectation of independent investigators contributing distinct and essential components to one unified research plan.

For practical support, the announcement points applicants to CDMRP human subjects guidance materials (including a Human Subject Resource Document) and provides a help desk phone number (301-682-5507) for difficulties accessing the full announcement.

Frequently Asked Questions (FAQ)

What is the DoD FY11 Prostate Cancer Synergistic Idea Development Award (SIDA)?

The FY11 Prostate Cancer Synergistic Idea Development Award (SIDA) is a Department of Defense (DoD) funding opportunity offered through the Congressionally Directed Medical Research Programs (CDMRP) Prostate Cancer Research Program (PCRP). It is designed to accelerate meaningful progress in prostate cancer research by supporting highly innovative, team-based projects that rely on true collaboration and synergy.

What is the main goal of this award mechanism?

The mechanism is built around the idea that some of the biggest advances come from real collaboration across disciplines and viewpoints. The award aims to fund integrated projects that can solve a shared scientific problem in a way that a single lab, working alone, could not.

How many Principal Investigators (PIs) are required?

Projects must be jointly designed and conducted by either two or three independent, faculty-level (or equivalent) Principal Investigators.

Do the PIs have to be independent investigators?

Yes. The requirement is for two or three independent investigators at the faculty level (or equivalent), each contributing distinct and essential expertise to the unified project.

What does "synergy" mean in the context of this award?

Synergy means the proposal must clearly show what each PI uniquely contributes and how the combined approach accelerates progress beyond what would be achievable through separate, parallel projects. The application should explain how the collaboration is integrated rather than simply divided into independent parts.

Are multidisciplinary collaborations encouraged?

Yes. Multidisciplinary collaborations are welcomed, consistent with the program's emphasis on combining different perspectives and expertise to address a shared prostate cancer research problem.

Are multi-institution collaborations allowed?

Yes. Multi-institution collaborations are welcomed, but the application must explain how the team will function across sites, including communication, coordination, data sharing, and project integration.

Is an intellectual property (IP) plan required?

An intellectual property plan is required for multi-institution teams. The plan is intended to proactively address ownership and sharing of intellectual and material property and to prevent institutional policies from becoming barriers to collaboration.

What research areas are eligible under this opportunity?

The award supports new ideas and innovative approaches across the full range of prostate cancer research, from basic science through clinical research, with specific limitations on clinical trials (see below).

Is human subjects research allowed?

Yes, human subjects research is allowed only if it does not involve a clinical trial.

Are clinical trials allowed under SIDA?

No. Human subjects research is permitted only if it does not involve a clinical trial. Applicants who intend to conduct a clinical trial are directed to the FY11 PCRP Clinical Trial Award instead.

How does the announcement define a clinical trial?

A clinical trial is defined as prospective enrollment of human subjects where an intervention is tested for measurable outcomes related to safety, effectiveness, efficacy, or other direct effects of the intervention on the participant. The announcement lists examples of interventions including drugs, devices, biologics, surgery, and behavioral interventions.

What if my project includes an intervention in human subjects?

If your project prospectively enrolls human subjects to test an intervention for measurable outcomes related to safety, effectiveness, efficacy, or other direct effects, it meets the announcement's definition of a clinical trial and is not appropriate for this mechanism.

Are population-based studies a fit for this award?

Investigators planning population-based studies are encouraged to consider the FY11 PCRP Population Based Research Award rather than this SIDA mechanism.

Is preliminary data required?

No. Preliminary data relevant to prostate cancer is encouraged but not required. This reflects the program's interest in enabling novel, potentially high-impact directions that may not yet have extensive pilot data.

If preliminary data are included, whose data should they be?

If preliminary data are included, the announcement states they should come from the participating PIs or members of the collaborating team.

Does the program support high-risk, high-reward ideas?

The program emphasizes innovation and recognizes that higher-risk ideas may be part of groundbreaking work. However, proposals are still expected to be grounded in a sound scientific rationale supported by logical reasoning and/or a critical analysis of existing literature.

Do projects need to align with the FY11 PCRP overarching challenges?

Applicants are strongly encouraged to align with one of the FY11 PCRP overarching challenges.

What if my project does not directly address an overarching challenge?

If a project does not directly address one of the FY11 PCRP overarching challenges, the application must clearly explain why it still meets a critical need in prostate cancer research and/or patient care.

How competitive is this mechanism?

The announcement notes that since the mechanism began in FY07, it attracted 260 proposed projects, with 26 projects (57 individual awards) recommended for funding, indicating a competitive program focused on standout concepts.

Who is the sponsoring agency for this opportunity?

The agency listed is the Department of the Army (USAMRAA), operating under the DoD CDMRP Prostate Cancer Research Program (PCRP).

What is the Funding Opportunity Number?

The Funding Opportunity Number is W81XWH-11-PCRP-SIDA.

What is the CFDA number for this opportunity?

The CFDA number is 12.420 (Military Medical Research and Development).

When was this opportunity posted, and what were the key dates?

The opportunity was posted on April 21, 2011. The original and current closing date was August 23, 2011. The archive date was September 22, 2011.

How much funding was expected to be available, and how many awards were anticipated?

The estimated total funding was $8.4 million, with an expected 7 awards.

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

Who is eligible to apply?

Eligibility is listed as unrestricted (open to any entity type), subject to any additional eligibility clarifications included in the full announcement.

How are awards structured for collaborative teams?

Although collaborators jointly develop a single integrated project, each partner is formally recognized as a PI, submits a separate application, and receives an individual award. This structure reinforces that the collaborating investigators are independent and each provides a distinct, essential contribution to the unified research plan.

Is there guidance available for human subjects requirements?

Yes. The announcement points applicants to CDMRP human subjects guidance materials, including a Human Subject Resource Document.

Where can applicants get help if they cannot access the full announcement?

The announcement provides a help desk phone number for difficulties accessing the full announcement: 301-682-5507.

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