DOD FY12 Duchenne Muscular Dystrophy Therapeutic Idea Award | Apply Online

Opportunity Summary:

The DOD FY12 Duchenne Muscular Dystrophy Therapeutic Idea Award (Funding Opportunity Number W81XWH-12-DMDRP-TIA) is a Department of Defense research funding opportunity under the U.S. Army Medical Research Acquisition Activity (USAMRAA) and the Duchenne Muscular Dystrophy Research Program (DMDRP). Its overarching aim aligns with the DMDRP vision: to extend and improve function, quality of life, and lifespan for people diagnosed with Duchenne muscular dystrophy (DMD). Within that mission, this specific award focuses on helping move the field toward new treatments by supporting early-stage therapeutic concepts that could generate influential data, open new research directions, and ultimately speed the path toward later-stage development and clinical evaluation. At the same time, the program is interested in work that helps the community better understand why some therapeutic approaches succeed or fail, including lessons learned from prior clinical trial outcomes, even though this particular mechanism does not permit running clinical trials.

This mechanism is explicitly positioned as a "Therapeutic Idea Award," meaning it is intended for novel, conceptually innovative projects that are still at a relatively early point in development. The emphasis is on high risk/high reward research, where the ideas may be unproven but are grounded in a strong scientific rationale and presented with a well-formulated, testable hypothesis. The program is looking for proposals that can produce high-impact insights or proof-of-concept results that meaningfully advance the DMD therapeutics landscape, rather than incremental extensions of established approaches. In practical terms, the ideal project under this mechanism would be one where a strong biological or translational argument is paired with a clear experimental plan designed to quickly test the core idea and generate decisive data that can inform next steps.

In terms of what is allowed, the announcement permits research involving human subjects and human anatomical substances, which can include studies using human-derived samples, tissues, or datasets where appropriate and compliant with applicable rules. However, despite the DMDRP-wide interest in accelerating clinical testing, clinical trials themselves are not allowed under this specific funding opportunity. That boundary signals that the award is meant to support foundational and preclinical work, early translational studies, and other investigational activities that can de-risk an approach and prepare it for future clinical-stage funding mechanisms.

Administratively, the opportunity is categorized as discretionary funding and supports projects through either a cooperative agreement or a grant, under the broader activity category of science and technology and other research and development. The total estimated funding listed is $480,000, with an expectation of making 1 award, and it does not require cost sharing or matching funds. Eligibility is described as unrestricted, meaning the competition is broadly open to many entity types, subject to any additional eligibility clarifications contained in the full announcement. Key dates show it was posted on June 6, 2012, with an original and current closing date of November 7, 2012, and an archive date of December 7, 2012. The associated CFDA number is 12.420 (Military Medical Research and Development), reflecting its placement within the Department of Defense medical R&D portfolio. For assistance accessing the full announcement or submitting materials, the listed contact is the CDMRP Help Desk (including PA HELP and eReceipt HELP) at 301-682-5507 and help@cdmrp.org.

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