DOD FY12 Lung Cancer Translational Research Partnership Award | Apply Online

Opportunity Summary:

The DOD FY12 Lung Cancer Translational Research Partnership Award (TRPA) is a funding opportunity from the Department of the Army (USAMRAA) under the Lung Cancer Research Program that is meant to speed up the translation of lung cancer research ideas into practical clinical use. The core purpose is to push beyond traditional single-investigator projects by requiring a true, integrated partnership between two independent, faculty-level (or equivalent) investigators who bring different strengths to the table. The program is designed around the idea that some of the most clinically meaningful advances in lung cancer happen when laboratory discovery and patient-centered clinical insight are developed together from the start, rather than handed off late in the process.

A central requirement is that the research team must consist of one laboratory scientist and one clinician, and the application must clearly demonstrate that both partners contributed equally and intellectually to the research concept, study design, and overall strategy. This is not meant to be a “division of labor” arrangement where one person leads and the other provides support. In particular, proposals will not fit the intent of the award if the clinician’s role is limited to providing tissue samples, supplying access to patients, or serving primarily as a recruitment pipeline. The award expects the clinical partner to be substantively involved in shaping the research questions, aligning experiments with clinical realities, and helping define how results could become clinically useful. At least one member of the partnership must already have experience in lung cancer research or in the care of lung cancer patients, which helps ensure the project stays grounded in real lung cancer needs and context.

The projects supported are explicitly translational in nature, meaning they should connect strong mechanistic or biological work to a path toward clinical application. Multi-institutional collaborations are encouraged because they can bring together specialized resources, patient populations, and complementary expertise, but they are not required. The announcement also encourages submissions from and partnerships with investigators at Military Medical Treatment Facilities, military laboratories, Department of Veterans Affairs medical centers and research labs, and commercial organizations, reflecting an interest in leveraging diverse settings and capabilities that can accelerate practical outcomes.

In terms of what the award will and will not fund, this mechanism does not support the conduct of clinical trials as a primary activity. However, it can support correlative studies linked to an already existing clinical trial, such as biomarker analyses or studies that connect clinical outcomes with molecular or imaging findings. It can also support work aimed at developing or refining clinical endpoints that could be used in future clinical trials, which is often a key translational bottleneck. Beyond these clinical-adjacent activities, the award allows preclinical research, including studies in animal models, research involving human subjects (as appropriate to the project scope and regulations), and work using human anatomical substances. A critical feasibility expectation is that preliminary data are required to justify the hypotheses and research approach, although the preliminary data do not have to be generated specifically in lung cancer, as long as they credibly support the proposed direction.

Administratively, the opportunity was posted on April 17, 2012, with an application closing date of September 20, 2012, and an archive date of October 20, 2012. The funding instrument type is listed as cooperative agreement/grant under a discretionary program in the science and technology/research and development category. The program anticipated making about three awards, with an estimated total funding amount of $4,320,000. There is no cost-sharing or matching requirement. Eligibility is described as unrestricted (open to any type of entity), subject to any clarifications in the full announcement. The CFDA listing associated with the program is 12.420, Military Medical Research and Development. For technical issues accessing the full announcement, the contact point is the CDMRP Help Desk (help@cdmrp.org; 301-682-5507).

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