Opportunity Information: Apply for W81XWH 13 MRPRA MRFA
Apply for W81XWH 13 MRPRA MRFA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD FY13 Militarily Relevant Peer Reviewed Alzheimers Disease Military Risk Factors Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Aug 21, 2013 and posted on Aug 21, 2013.
- Applicants must submit their applications by Dec 16, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,500,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DOD FY13 Militarily Relevant Peer Reviewed Alzheimers Disease Military Risk Factors Research Award (MRFA) was a Department of the Army/USAMRAA funding opportunity designed to support high-impact research on how traumatic brain injury (TBI) in military populations may be linked to the later development of Alzheimers disease (AD). The central goal was to push forward systematic, population-based studies that can clarify whether, how, and under what conditions TBIs contribute to Alzheimers-like outcomes, including dementia-related changes as well as related cognitive, emotional, and behavioral problems that can interfere with daily functioning.
This program specifically emphasized projects that would work with well-defined, already identified study cohorts rather than proposing to build a brand-new cohort from scratch. Applicants were expected to clearly describe how they would characterize the relationship between a history of TBI and subsequent Alzheimers disease, including careful attention to the real-world cognitive and behavioral symptoms that lead to functional impairment. The announcement highlighted the broad spectrum of long-term issues seen after TBI in service members, such as memory loss, depression, aggression, and neurological symptoms that resemble or overlap with other brain disorders, and it encouraged proposals that can distinguish and measure these outcomes in a rigorous way.
Methodologically, the opportunity encouraged studies that combine multiple measurement approaches instead of relying on a single type of data. Examples explicitly mentioned include neuropsychological testing, brain imaging, genomics, and cerebrospinal fluid measures, reflecting an interest in studies that can connect clinical symptoms with biological and structural indicators of disease processes. The program also encouraged investigators to form interdisciplinary teams or consortia, recognizing that answering complex questions about TBI and AD risk often requires coordinated expertise across neurology, psychiatry, epidemiology, imaging, biomarker science, genetics, and biostatistics.
From an administrative standpoint, this was a discretionary science and technology/research and development award offered as a grant or cooperative agreement under CFDA 12.420 (Military Medical Research and Development). The opportunity anticipated making 1 award, with an estimated total funding amount of $5,500,000, and it did not require cost sharing or matching. Eligibility was described as unrestricted, meaning it was broadly open to different types of applicant organizations, subject to any additional eligibility clarifications in the full text of the announcement. The opportunity was posted on August 21, 2013, with an application deadline of December 16, 2013, and it was later archived on January 15, 2014.
Overall, the MRFA aimed to generate evidence that directly benefits the military community by improving understanding of long-term neurological risks following TBI, while also serving a wider public purpose by producing findings relevant to civilians who experience TBI through sports injuries, accidents, or other causes. For access issues related to the full announcement, the listed point of contact was the TATRC Help Desk at programannouncements@tatrc.org.
Frequently Asked Questions (FAQs)
What is the DOD FY13 Militarily Relevant Peer Reviewed Alzheimer's Disease Military Risk Factors Research Award (MRFA)?
The MRFA was a Department of the Army/USAMRAA funding opportunity intended to support high-impact research examining how traumatic brain injury (TBI) in military populations may be linked to the later development of Alzheimer's disease (AD) and AD-like outcomes.
What was the central goal of this funding opportunity?
The central goal was to advance systematic, population-based studies that clarify whether, how, and under what conditions TBIs contribute to Alzheimer's-like outcomes. This included studying dementia-related changes as well as cognitive, emotional, and behavioral problems that interfere with daily functioning.
What specific relationship was the program trying to characterize?
The program emphasized characterizing the relationship between a history of TBI and subsequent Alzheimer's disease, including careful attention to real-world symptoms that drive functional impairment.
What kinds of long-term issues after TBI were highlighted in the announcement?
The opportunity highlighted a broad spectrum of long-term issues observed after TBI in service members, including memory loss, depression, aggression, and neurological symptoms that resemble or overlap with other brain disorders.
Did the program expect applicants to create a brand-new study cohort?
No. The program specifically emphasized projects that would use well-defined, already identified study cohorts rather than proposing to build a brand-new cohort from scratch.
What type of study design or approach was encouraged?
The opportunity encouraged systematic, population-based research using existing cohorts, with rigorous efforts to distinguish, measure, and interpret outcomes that overlap with other neurological or psychiatric conditions.
What outcomes were in scope besides Alzheimer's disease itself?
In addition to Alzheimer's disease, the announcement emphasized outcomes that can resemble Alzheimer's-like trajectories or dementia-related changes, as well as cognitive, emotional, and behavioral problems that interfere with daily functioning.
What measurement approaches were encouraged?
The program encouraged studies that combine multiple measurement approaches rather than relying on a single data type. Examples explicitly mentioned include neuropsychological testing, brain imaging, genomics, and cerebrospinal fluid measures.
Why did the program encourage combining multiple measurement approaches?
The stated interest was in studies that can connect clinical symptoms with biological and structural indicators of disease processes, strengthening the ability to interpret how TBI history may relate to Alzheimer's disease risk or Alzheimer's-like outcomes.
Were interdisciplinary teams or consortia encouraged?
Yes. The opportunity encouraged investigators to form interdisciplinary teams or consortia, reflecting that complex questions about TBI and Alzheimer's risk often require coordinated expertise.
What disciplines were relevant to the interdisciplinary work described?
The announcement referenced coordinated expertise across neurology, psychiatry, epidemiology, imaging, biomarker science, genetics, and biostatistics.
Which agency or office offered this opportunity?
This was a Department of the Army/USAMRAA funding opportunity.
What was the assistance listing (CFDA) number associated with this opportunity?
The opportunity was offered under CFDA 12.420 (Military Medical Research and Development).
What award mechanisms were anticipated?
The announcement described the award as a discretionary science and technology/research and development award offered as a grant or cooperative agreement.
How many awards were anticipated?
The opportunity anticipated making 1 award.
What was the estimated total funding amount?
The estimated total funding amount was $5,500,000.
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
Who was eligible to apply?
Eligibility was described as unrestricted, meaning it was broadly open to different types of applicant organizations, subject to any additional eligibility clarifications in the full text of the announcement.
When was the opportunity posted?
The opportunity was posted on August 21, 2013.
What was the application deadline?
The application deadline was December 16, 2013.
When was the opportunity archived?
The opportunity was archived on January 15, 2014.
What broader impact did the program aim to have beyond the military community?
While the program aimed to generate evidence that directly benefits the military community by improving understanding of long-term neurological risks following TBI, it also sought to produce findings relevant to civilians who experience TBI through sports injuries, accidents, or other causes.
What was the point of contact for access issues related to the full announcement?
For access issues related to the full announcement, the listed point of contact was the TATRC Help Desk at programannouncements@tatrc.org.
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