Opportunity Information: Apply for W81XWH 15 DMRDP MSIS REALMETRX

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD FY15 Metrics Transitioning Training to Reality (RealMETRX) Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Jun 11, 2015 and posted on Jun 11, 2015.
  • Applicants must submit their applications by Nov 12, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $3,200,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 15 DMRDP MSIS REALMETRX

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Opportunity Summary:

The DoD FY15 Metrics Transitioning Training to Reality (RealMETRX) Award (Funding Opportunity Number W81XWH-15-DMRDP-MSIS-REALMETRX) was a Department of the Army/USAMRAA research funding opportunity under CFDA 12.420 (Military Medical Research and Development) aimed at solving a very practical problem in military and civilian medicine: simulation-based training is widely used, but the field still struggles to prove, with objective evidence, which simulation-measurable indicators actually predict better real-world patient care. RealMETRX sought projects that would determine, define, and validate training proficiency metrics and evaluation criteria that can be captured in medical simulation systems and that are empirically linked to optimal clinical performance and patient outcomes. The program emphasized acute trauma care, critical care, and prolonged care, and encouraged inclusion of military-relevant injuries while still producing metrics broad enough to generalize across military, VA, academic centers, rural settings, public/private hospitals, and even international contexts. The funding mechanism was a grant/cooperative agreement, with an estimated total of $3.2M and about 2 expected awards, no cost sharing required, and eligibility described as unrestricted. A core expectation was that awardees would use rigorous statistical approaches to identify the best-performing metrics and show that they track the transition from simulation training to actual practice across as much of the continuum of care as possible (from first encounter through discharge and near-term follow-up).

For measuring effective decision making (for novices and more experienced clinicians), the strongest approach is usually not a single score but a structured set of metrics that capture (1) the process of decision making under uncertainty, (2) the timeliness and appropriateness of actions taken, (3) teamwork and communication behaviors that directly influence execution, and (4) patient-centered outcomes and safety signals that are plausibly sensitive to training. In trauma and critical care, good decision making is often reflected in whether the clinician recognizes key patterns early, selects the right priorities, sequences actions correctly, adapts to changing physiology, and avoids preventable harm. That can be measured in simulation through time-stamped event logs, physiologic trajectories produced by the simulator, eye tracking or attention proxies when available, structured rater instruments, and analysis of the decisions chosen at critical branching points. In addition, because RealMETRX emphasizes connection to real care, the same constructs should be mapped to clinical data sources (EHR timestamps, order sets, vitals trends, complications, and follow-up events) to test whether simulation performance predicts actual performance after controlling for case-mix and context.

The most defensible decision-making metrics tend to fall into several categories. First are time-to-critical-action measures that reflect prioritization and recognition, such as time to hemorrhage control, time to activation of massive transfusion protocols, time to antibiotic administration in suspected sepsis, time to airway stabilization when indicated, time to lactate measurement and reassessment, and time to escalation (calling for help, consult, transfer to higher level of care). These are attractive because they are objective, timestampable in both simulation and clinical practice, and often associated with outcomes. Second are guideline- and evidence-concordance measures, where the evaluation checks whether actions match validated pathways (ATLS/trauma resuscitation principles, ventilator lung-protective strategies, sepsis bundles, DVT prophylaxis decisions, sedation/analgesia best practices, transfusion ratios, damage control resuscitation, and appropriate imaging choices). Third are error and near-miss measures, which can include omission errors (failure to reassess, failure to recognize shock, failure to consider reversible causes), commission errors (unnecessary intubation, inappropriate fluid choice, contraindicated medication), and safety-critical violations (wrong dose, wrong route, contamination breaks, failure to confirm tube placement). Fourth are adaptive decision-making measures that look at whether the clinician updates the plan when new information arrives (dynamic re-triage, changing differential diagnosis, revising ventilator settings when compliance changes, or stopping a harmful intervention promptly). In simulation, this can be captured as “decision pivots” and the latency between a physiologic change and the corrective action.

To better reflect the multitude of variables across the continuum of care from initial encounter to discharge and 6-month follow-up, the best metric strategy is to build a chain of linked indicators rather than jumping straight to long-term outcomes alone. Long-term outcomes are important, but they are heavily confounded by injury severity, comorbidities, resources, and post-discharge social factors. Training-sensitive indicators can be built as intermediate outcomes and process reliability measures that are more directly attributable to decision quality. Examples include stabilization quality (shock index improvement, lactate clearance, avoidance of hypoxemia/hypotension episodes, timely temperature management), complication prevention (ventilator-associated events, catheter-associated infections, pressure injuries, delirium burden, DVT/PE prevention adherence), and discharge readiness measures (med reconciliation quality, follow-up scheduling, return precautions documented and communicated, early outpatient complication detection plans). Near-term follow-up metrics within 6 months could include unplanned readmissions, ED revisits, preventable complications, functional outcomes when feasible (return to duty/work, mobility, neurocognitive function after TBI), and patient-reported outcomes. The key is to treat these as downstream validation targets while still focusing training measurement on upstream decisions and behaviors that plausibly drive them.

A particularly powerful set of evaluation criteria for decision making involves measuring situation awareness, clinical reasoning, and cognitive workload in ways that can be operationalized. Situation awareness can be approximated with “information gathering completeness and relevance” (what data were sought, in what order, and whether irrelevant testing was minimized), “anticipation and planning” (whether the clinician prepared for deterioration, pre-briefed the team, staged equipment, or ordered blood early), and “reassessment discipline” (frequency and appropriateness of reassessments after interventions). Clinical reasoning quality can be assessed by scoring differential diagnosis breadth early vs late, appropriateness of hypothesis updates, and consistency between stated diagnosis and actions (the plan matches the claimed mental model). Cognitive workload and stress resilience can be measured via performance under time pressure (decision latency, error rate under load), secondary-task performance in simulation, or physiologic proxies if available; even without advanced sensors, variability in decision times and escalation patterns under increasing scenario complexity can serve as an indirect workload marker.

Because RealMETRX explicitly wants metrics that can accelerate maturity and experience, the most useful evaluation criteria are those that show clear learning curves and discriminate between novice, intermediate, and expert performers. Commonly, experts distinguish themselves not just by speed, but by selecting the right actions with fewer unnecessary steps, maintaining broader awareness, and preventing errors. Metrics that often show this include efficiency measures (task completion with fewer non-value-added actions, fewer redundant orders, fewer cancellations), prioritization accuracy (correct ordering of interventions), and “stability of performance” (less variance across scenarios, better performance in rare but critical events). Another expert-like hallmark is calibrated confidence: knowing when to act decisively and when to pause and gather more data. This can be measured by comparing confidence ratings to correctness (calibration curves), or by examining inappropriate certainty (aggressive irreversible actions taken with weak evidence) versus appropriate uncertainty management (seeking confirmatory signs, escalating to expert consultation). In team-based trauma and ICU care, maturity also shows up in closed-loop communication, role clarity, effective delegation, and early activation of resources; these can be rated with validated teamwork frameworks and also captured with objective speech-event coding in recorded simulations.

For comparing novices and not-so-novice personnel to high-performing experienced colleagues, the cleanest method is to define benchmark distributions based on expert performance and then compute gap-to-benchmark scores across multiple dimensions. That can include z-scores against expert medians for time-to-action, error rates, adherence measures, and physiologic outcome proxies within the simulation (time in hypotension, time in hypoxemia, total “harm exposure” minutes). A useful framing is “entrustment”: how much supervision a clinician would require for a given scenario. Entrustable Professional Activities (EPAs) or entrustment scales can be adapted to acute care tasks (leading a trauma resuscitation, managing ventilated shock, initiating massive transfusion, coordinating prolonged field care), with anchors that translate to observable behaviors. Pairing entrustment ratings with objective logs helps reduce subjectivity. Another strong approach is generalizability theory or many-facet Rasch modeling to account for rater severity, scenario difficulty, and learner ability, enabling fairer comparisons across different cases and evaluators.

On the statistical side, the opportunity implicitly pushes teams to move beyond simple checklists and toward validated measurement models. That typically means identifying candidate metrics, testing reliability (inter-rater reliability for observational scores; test-retest reliability; internal consistency where relevant), demonstrating construct validity (experts outperform novices; performance improves with training), and then demonstrating criterion validity (simulation metrics predict clinical performance or outcomes). Because real outcomes are confounded, the best analyses often use multilevel modeling (patients nested within clinicians nested within sites), risk adjustment (injury severity scores, comorbidity indices), and propensity or matching techniques when comparing trained vs untrained cohorts. For selecting the “best” indicators among many candidates, approaches like regularized regression (LASSO/elastic net), random forests/gradient boosting with careful cross-validation, and interpretable models that allow clinical insight are common. A practical deliverable is a small set of high-yield composite indices (for example, a Trauma Decision Quality Index) built from weighted components that remain interpretable and can be computed in both simulation and clinical datasets.

Within acute trauma care, high-value metrics often include early recognition and control of life threats (airway compromise, tension pneumothorax, major hemorrhage), correct triage decisions (appropriate imaging vs OR, transfer timing), and avoidance of secondary insults (hypotension and hypoxia in TBI, hypothermia in hemorrhage). Simulation can measure the “burden” of these insults as area-under-the-curve time below thresholds, plus the latency to correction. In critical care, decision metrics that map to outcomes include ventilator strategy choices (tidal volume per predicted body weight, plateau pressure awareness, PEEP titration rationale), shock management patterns (fluid responsiveness assessment, timely vasopressor initiation, source control decisions), and sedation/analgesia/delirium practices. In prolonged care, especially in austere or resource-limited environments, metrics shift toward planning, resource stewardship, complication prevention over time, handoffs, documentation quality, and contingency management. Decision making here is less about single rapid actions and more about maintaining patient stability, anticipating deterioration, and balancing risk when definitive care is delayed.

If the goal is to accelerate acquisition of maturity, the most actionable metrics are those that can drive feedback and deliberate practice. Metrics should therefore be (1) specific enough to coach (for example, “reassessed BP within 3 minutes after intervention” rather than a generic “good resuscitation”), (2) sensitive to improvement, and (3) linked to patient safety. Dashboards that show a learner’s trajectory over repeated scenarios, highlight their most frequent decision bottlenecks (late escalation, missed reassessment, inappropriate fixation), and compare them to expert patterns can shorten the path to competence. Including scenario complexity scaling is also important: learners should be measured across routine cases and edge cases where cognitive traps are common, because that is where expert decision making diverges most clearly.

Finally, RealMETRX’s emphasis on “training sensitive outcome indicators versus those currently used to evaluate tasks, skills, and procedures” suggests a shift from counting whether someone performed a procedure to measuring whether the overall care plan was correct, timely, coordinated, and safe. The best metrics for that are often hybrid measures: objective timestamps and physiologic impact paired with structured assessments of reasoning and teamwork. Done well, the result is a set of validated indicators that can be captured in simulation, that discriminate levels of expertise, that improve with targeted training, and that meaningfully predict better clinical care from first contact through discharge and near-term follow-up.

RealMETRX (DoD FY15 Metrics Transitioning Training to Reality) - Frequently Asked Questions

1) What is the RealMETRX award?

RealMETRX (Metrics Transitioning Training to Reality) is a Department of Defense (Department of the Army/USAMRAA) research funding opportunity focused on identifying and validating objective, simulation-captured training metrics that are empirically linked to better real-world clinical performance and patient outcomes.

2) What is the official funding opportunity number for this program?

The Funding Opportunity Number is W81XWH-15-DMRDP-MSIS-REALMETRX.

3) What CFDA program is associated with this opportunity?

This opportunity is under CFDA 12.420, Military Medical Research and Development.

4) What problem is RealMETRX trying to solve?

Simulation-based training is widely used in military and civilian medicine, but the field has struggled to demonstrate (with objective evidence) which simulation-measurable indicators actually predict improved real-world patient care. RealMETRX sought projects that define and validate proficiency metrics and evaluation criteria that translate from simulation performance to clinical performance.

5) What types of projects were sought under RealMETRX?

Projects aimed to determine, define, and validate training proficiency metrics and evaluation criteria that can be captured in medical simulation systems and are empirically linked to optimal clinical performance and patient outcomes.

6) Which clinical areas did the program emphasize?

The program emphasized acute trauma care, critical care, and prolonged care.

7) Did the program encourage military-relevant topics?

Yes. The program encouraged inclusion of military-relevant injuries while still aiming for metrics broad enough to generalize across multiple settings.

8) How broadly were the resulting metrics expected to generalize?

Metrics were encouraged to be applicable across military settings, the VA, academic centers, rural settings, public and private hospitals, and even international contexts.

9) What funding mechanism was used?

The mechanism was a grant/cooperative agreement.

10) What was the estimated total funding and expected number of awards?

The opportunity described an estimated total of $3.2M and about 2 expected awards.

11) Was cost sharing required?

No cost sharing was required.

12) Who was eligible to apply?

Eligibility was described as unrestricted.

13) What was a core expectation for how awardees would select metrics?

A core expectation was to use rigorous statistical approaches to identify best-performing metrics and demonstrate that these metrics track the transition from simulation-based training to actual clinical practice.

14) Across what span of care did RealMETRX expect metrics to track performance?

The opportunity emphasized tracking across as much of the continuum of care as possible, from first encounter through discharge and near-term follow-up.

15) For decision-making assessment, did RealMETRX favor a single score or multiple measures?

The information emphasizes that the strongest approach is usually a structured set of metrics rather than a single score, capturing decision process under uncertainty, action timeliness/appropriateness, teamwork and communication, and patient-centered outcomes and safety signals.

16) What are examples of objective decision-making metrics that can be captured in simulation and also mapped to clinical care?

Examples include time-to-critical-action measures (timestamped), guideline/evidence concordance measures, error and near-miss measures, and adaptive decision-making measures such as decision pivots and latency between physiologic change and corrective action.

17) What are examples of time-to-critical-action measures mentioned for trauma and critical care?

Examples include time to hemorrhage control, time to massive transfusion protocol activation, time to antibiotic administration in suspected sepsis, time to airway stabilization when indicated, time to lactate measurement and reassessment, and time to escalation (calling for help, consult, or transfer).

18) What are guideline- and evidence-concordance measures in this context?

These measures evaluate whether actions match validated pathways, such as ATLS/trauma resuscitation principles, lung-protective ventilation strategies, sepsis bundles, DVT prophylaxis decisions, sedation/analgesia best practices, transfusion ratios and damage control resuscitation, and appropriate imaging choices.

19) What types of errors and near-misses were highlighted as measurable?

Examples include omission errors (failure to reassess, failure to recognize shock, failure to consider reversible causes), commission errors (unnecessary intubation, inappropriate fluid choice, contraindicated medication), and safety-critical violations (wrong dose, wrong route, contamination breaks, failure to confirm tube placement).

20) What is meant by adaptive decision-making measures?

These measures assess whether the clinician updates the plan appropriately as new information arrives (for example, dynamic re-triage, updating the differential diagnosis, revising ventilator settings when compliance changes, or stopping a harmful intervention promptly). In simulation, this can be captured as decision pivots and the latency from physiologic change to corrective action.

21) Why does the opportunity suggest using a chain of linked indicators rather than only long-term outcomes?

Long-term outcomes are important but heavily confounded by factors such as injury severity, comorbidities, resources, and post-discharge social determinants. A linked chain of training-sensitive intermediate outcomes and process reliability measures is more directly attributable to decision quality and can still be validated downstream against longer-term outcomes.

22) What are examples of training-sensitive intermediate outcomes across the continuum of care?

Examples include stabilization quality (shock index improvement, lactate clearance, avoidance of hypoxemia/hypotension episodes, timely temperature management), complication prevention (ventilator-associated events, catheter-associated infections, pressure injuries, delirium burden, DVT/PE prevention adherence), and discharge readiness measures (medication reconciliation quality, follow-up scheduling, return precautions documented and communicated, and early outpatient complication detection plans).

23) What near-term follow-up metrics (within 6 months) were mentioned?

Examples include unplanned readmissions, emergency department revisits, preventable complications, functional outcomes when feasible (return to duty/work, mobility, neurocognitive function after TBI), and patient-reported outcomes.

24) What kinds of data sources were suggested for connecting simulation metrics to real clinical performance?

The information references mapping constructs to clinical data sources such as EHR timestamps, order sets, vital trends, complications, and follow-up events, while controlling for case mix and context.

25) What simulation data streams were described as useful for measuring decision making?

Examples include time-stamped event logs, physiologic trajectories produced by the simulator, eye tracking or attention proxies when available, structured rater instruments, and analysis of decisions at critical branching points.

26) How can situation awareness be operationalized as measurable criteria?

Situation awareness can be approximated using measures such as information gathering completeness and relevance (what data were sought and in what order), anticipation and planning (preparing for deterioration, staging equipment, ordering blood early, pre-briefing), and reassessment discipline (frequency and appropriateness of reassessments after interventions).

27) How can clinical reasoning quality be evaluated under the approach described?

Clinical reasoning quality can be assessed by scoring differential diagnosis breadth early versus late, appropriateness of hypothesis updates, and consistency between stated diagnosis and actions (whether the plan matches the clinician's mental model).

28) How was cognitive workload or stress resilience suggested to be measured?

Examples include decision latency and error rate under load, secondary-task performance in simulation, physiologic proxies when available, and indirect markers such as variability in decision times and escalation patterns as scenario complexity increases.

29) What characteristics make a metric useful for showing maturation from novice to expert?

Metrics were described as especially useful when they show clear learning curves, discriminate between novice/intermediate/expert levels, and reflect expert patterns such as fewer unnecessary steps, broader awareness, and fewer errors (not just faster performance).

30) What are examples of "expert-like" performance metrics mentioned?

Examples include efficiency measures (fewer non-value-added actions, fewer redundant orders, fewer cancellations), prioritization accuracy (correct ordering of interventions), stability of performance (less variance across scenarios), and calibrated confidence (appropriate decisiveness versus premature irreversible action with weak evidence).

31) How can teamwork and communication be incorporated into decision-making evaluation?

Team-based measures can include ratings of closed-loop communication, role clarity, delegation, and early activation of resources using validated teamwork frameworks, and may also be captured with objective speech-event coding from recorded simulations.

32) What is a "gap-to-benchmark" approach for comparing learners to experts?

This approach defines benchmark distributions based on expert performance and computes gap-to-benchmark scores across dimensions such as time-to-action, error rates, adherence measures, and physiologic outcome proxies (for example, z-scores against expert medians).

33) What is "entrustment" and how does it relate to measuring decision making?

Entrustment frames evaluation in terms of how much supervision a clinician would require for a given scenario. Entrustable Professional Activities (EPAs) or entrustment scales can be adapted to acute care tasks (leading trauma resuscitation, managing ventilated shock, initiating massive transfusion, coordinating prolonged field care) and paired with objective logs to reduce subjectivity.

34) What measurement or modeling methods were mentioned for making comparisons fair across raters and scenarios?

Generalizability theory and many-facet Rasch modeling were mentioned as approaches to account for rater severity, scenario difficulty, and learner ability.

35) What types of statistical evidence were implied as important for validating metrics?

The description emphasizes moving beyond simple checklists by testing reliability (inter-rater reliability, test-retest reliability, internal consistency where relevant), construct validity (experts outperform novices; performance improves with training), and criterion validity (simulation metrics predict clinical performance or outcomes).

36) What analytic approaches were suggested for handling confounding and real-world complexity?

Examples include multilevel modeling (patients nested within clinicians nested within sites), risk adjustment (injury severity and comorbidity indices), and propensity or matching techniques when comparing trained versus untrained cohorts.

37) How might teams select a small number of high-yield indicators from many candidate metrics?

Approaches mentioned include regularized regression (LASSO/elastic net), random forests/gradient boosting with careful cross-validation, and interpretable models that preserve clinical insight.

38) What is an example of a practical metric deliverable described in the opportunity narrative?

A practical deliverable mentioned is a small set of interpretable composite indices (for example, a Trauma Decision Quality Index) built from weighted components that can be computed in both simulation and clinical datasets.

39) What high-value trauma decision metrics were highlighted?

Examples include early recognition and control of life threats (airway compromise, tension pneumothorax, major hemorrhage), correct triage decisions (appropriate imaging versus OR, transfer timing), and avoiding secondary insults (hypotension and hypoxia in TBI, hypothermia in hemorrhage).

40) How can simulations quantify "secondary insult burden" in trauma?

The narrative describes measuring burden as area-under-the-curve time below thresholds (for example, minutes in hypotension or hypoxemia) and the latency to correction.

41) What critical care decision metrics were described as mapping well to outcomes?

Examples include ventilator strategy choices (tidal volume per predicted body weight, plateau pressure awareness, PEEP titration rationale), shock management patterns (fluid responsiveness assessment, timely vasopressor initiation, source control decisions), and sedation/analgesia/delirium practices.

42) How do decision-making metrics shift in prolonged care or austere environments?

In prolonged care, metrics shift toward planning, resource stewardship, complication prevention over time, handoffs, documentation quality, and contingency management, reflecting the need to maintain stability and balance risk when definitive care is delayed.

43) What makes a metric actionable for feedback and deliberate practice?

Metrics were described as most actionable when they are specific enough to coach (for example, "reassessed BP within 3 minutes after intervention"), sensitive to improvement, and linked to patient safety.

44) What kinds of learner feedback tools were suggested?

The information mentions dashboards that show a learner's trajectory over repeated scenarios, highlight decision bottlenecks (late escalation, missed reassessment, inappropriate fixation), and compare patterns to expert performance.

45) Why is scenario complexity scaling important in this approach?

Measuring learners across routine cases and edge cases helps distinguish expert decision making, especially where cognitive traps are common, and supports a clearer assessment of stability and adaptability under increasing complexity.

46) How does RealMETRX differ from evaluating tasks, skills, and procedures in a traditional way?

The emphasis described is a shift from counting whether someone performed a procedure to measuring whether the overall care plan was correct, timely, coordinated, and safe, often using hybrid measures (objective timestamps and physiologic impact paired with structured assessments of reasoning and teamwork).

47) What overall outcome was RealMETRX aiming to produce for the field?

The intended result is a validated set of indicators that can be captured in simulation, discriminate levels of expertise, improve with targeted training, and meaningfully predict better clinical care from first contact through discharge and near-term follow-up.

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