DoD FY15 Peer Reviewed Alzheimer s Military Risk Factors Research Award | Apply Online

Opportunity Summary:

The DoD FY15 Peer Reviewed Alzheimer s Research Program (PRARP) Military Risk Factors Research Award (MRFA) is a funding opportunity from the Department of the Army (USAMRAA) designed to support high impact, systematic, population based research on how traumatic brain injury (TBI) may be linked to the later development of Alzheimer s disease (AD). The central goal is to generate evidence that clarifies whether, how, and in whom TBI contributes to progression toward AD, with results intended to benefit not only military Service members and Veterans, but also the broader civilian community. Projects are expected to go beyond general associations and clearly lay out how the research team will characterize the relationship between a history of TBI and subsequent AD outcomes, including careful description of cognitive and behavioral symptoms that translate into real world functional impairment in the study population.

A key expectation of this award is that applicants already have expedited access to a well defined, already identified cohort, and that they can provide data showing how that cohort will be used to test the proposed hypothesis or hypotheses. In other words, this mechanism is not meant for teams that are still trying to locate participants or build a cohort from scratch; the application must convincingly demonstrate that the cohort exists, is accessible quickly, and is appropriate for the planned analyses. While preliminary data is not strictly required, it is encouraged, and the program emphasizes that supporting data should strongly align with and substantiate the proposed research direction.

The MRFA encourages comprehensive study designs that use multiple, complementary measurement approaches to capture neurological change and clinical progression. Competitive applications are expected to think in an integrated way about assessment, for example combining neuropsychological testing with imaging approaches, genomics, and cerebrospinal fluid biomarkers, rather than relying on a single data stream. The program also explicitly encourages the formation of interdisciplinary teams or consortia, reflecting the idea that understanding TBI to AD trajectories often requires expertise spanning neurology, neuropsychology, epidemiology, imaging science, molecular biology, bioinformatics, and related fields.

In terms of the scientific problems the DoD is trying to push forward, applications must address one or more overarching challenges identified for FY15. These include the limited availability of research resources specifically suited to examining TBI and later AD in military and Veteran populations, the shortage of strong clinical or epidemiological studies focused on this interrelationship, and the need for diagnostic technologies, tests, or devices that can detect or track progression toward AD following TBI. Applicants are also encouraged to align with at least one of the listed FY15 focus areas, although work outside these areas can still be considered if the applicant makes a strong case for why it is relevant and necessary. The named focus areas include genomics, proteomics, and bioinformatics strategies to characterize neurological changes tied to TBI and subsequent AD; research into Tau pathology mechanisms that may connect TBI to AD; studies of non neuronal cells such as astrocytes and their roles in AD type neurodegeneration following TBI; and the development or application of anatomic or molecular imaging methods to capture TBI related changes and later AD associated progression.

The opportunity is open broadly with unrestricted eligibility in terms of entity type, but it sets clear expectations for leadership and expertise. The Principal Investigator must be at or above the Assistant Professor level (or equivalent), and while investigators may come from any discipline, the application must demonstrate that the study team has credible experience across both TBI and AD research. The funding instrument type listed includes cooperative agreement and grant, and the activity category is research and development (science and technology). The total estimated funding amount is $5,000,000 with an expectation of a single award, and there is no cost sharing or matching requirement.

One major boundary is that pharmacologic interventions are specifically discouraged under this program announcement. That includes clinical or basic research that requires investigational drugs or even FDA approved medicines as part of the proposed work. In practice, this steers applicants toward observational, epidemiological, biomarker, imaging, and mechanistic or diagnostic tool development studies rather than drug based trials.

Administrative details from the announcement include the funding opportunity number W81XWH 15 PRARP MRFA, CFDA 12.420 (Military Medical Research and Development), a posted and created date of July 20, 2015, and an original/current closing date of November 25, 2015 (archived December 25, 2015). For help accessing the full announcement, the listed contact is the CDMRP Help Desk (301 682 5507, help@eBRAP.org).

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Previous opportunity: DoD FY15 Peer Reviewed Alzheimer s Quality of Life Research Award

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