DoD FY15 Spinal Cord Injury Investigator Initiated Research Award | Apply Online

Opportunity Summary:

The DoD FY15 Spinal Cord Injury Investigator Initiated Research Award (SCIRP IIRA) is a Department of Defense funding opportunity designed to back investigator-driven studies that can meaningfully advance spinal cord injury (SCI) research and translate into better patient care and improved quality of life. The intent is to support projects that offer a clear, compelling contribution to the field, whether that contribution is a new scientific insight, a practical improvement in care delivery, or an intervention strategy that could ultimately help people living with SCI. While the program is open to a wide range of research approaches, applicants are expected to make a strong case for why their work matters both in the near term and over the long term.

For FY15, the program particularly encourages proposals aligned with one or more priority areas. One focus is the earliest phase of care: pre-hospital response, care delivered during transport (en route), and early hospital management after an SCI. Another priority is the development, validation, and optimal timing of interventions aimed at the consequences of SCI and recovery outcomes. Within that broad intervention theme, the announcement highlights several major complication areas that substantially affect daily life and long-term health, including bladder, bowel, and autonomic dysfunction; cardiometabolic dysfunction; neuropathic pain and sensory dysfunction; pressure ulcers; respiratory dysfunction; and sexual dysfunction. A third encouraged area is the identification and validation of best practices in SCI care, spanning critical care interventions, musculoskeletal health interventions, rehabilitation strategies, surgical interventions, and psychosocial or behavioral interventions, with explicit mention of relevance to military and Veteran populations.

Several core expectations shape what a competitive application looks like. Impact is central: proposals need to explain how the project could change understanding, practice, or outcomes, and they should spell out both short-term deliverables and longer-term implications for SCI research and care. Military relevance is also mandatory rather than optional. The proposed research must clearly connect to the needs of injured Service members, Veterans, and/or their family members and caregivers, and the application must explicitly describe that relevance. The program encourages collaboration with military clinicians and researchers, which can strengthen feasibility and relevance, but the key requirement is that the work is tied in a direct and understandable way to the military and Veteran SCI community.

The award also requires preliminary support for the proposed idea. Applicants must include preliminary and/or published data related to SCI and directly connected to the proposed project. The solicitation recognizes that early evidence can come from different sources, such as laboratory discoveries, population-based findings, clinical observations, or even well-supported anecdotal experience that motivates a testable research plan, but it still expects applicants to ground their proposal in real data rather than a purely speculative concept.

In terms of what kinds of research are allowed, the mechanism is broad across the pipeline from basic to translational science. It can include preclinical work in animal models, studies involving human subjects (so long as they are not clinical trials), and correlative or ancillary studies associated with an existing clinical trial. A crucial restriction is that clinical trials themselves are not permitted under this specific funding opportunity, so projects must be designed accordingly (for example, focusing on mechanistic studies, biomarker/correlation work, validation studies that are not trial-based, or other translational steps short of testing an intervention in a clinical trial framework).

Administratively, this opportunity was offered by the Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under Funding Opportunity Number W81XWH-15-SCIRP-IIRA. It supported science and technology and other research and development activities and used grant and cooperative agreement funding instruments. The program anticipated making about 9 awards with an estimated total funding level of $7.2 million, did not require cost sharing or matching, and listed eligibility as unrestricted (open to any type of entity, subject to any additional eligibility clarifications in the full announcement). The opportunity was posted June 2, 2015, with an original and final closing date of October 14, 2015, and it was archived November 13, 2015. For assistance accessing the full announcement, the contact listed was the CDMRP Help Desk (help@eBRAP.org, 301-682-5507).

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