Opportunity Information: Apply for W81XWH 15 GWIRP GWIERA
Apply for W81XWH 15 GWIRP GWIERA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Gulf War Illness Epidemiology Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Jul 9, 2015 and posted on May 14, 2015.
- Applicants must submit their applications by Oct 29, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,600,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Gulf War Illness Epidemiology Research Award (GWIERA) is a FY2015 grant and cooperative agreement opportunity from the Department of the Army (USAMRAA) under the Gulf War Illness Research Program. Offered for the first time in FY15, it is designed to fund population-based epidemiology studies that deepen understanding of how Gulf War Illness (GWI) has affected veterans who deployed during the 1990-1991 Persian Gulf War, with a particular emphasis on how outcomes have evolved over time. The program is centered on characterizing long-term patterns of mortality, morbidity, and symptom profiles in affected veterans, and comparing those patterns against appropriate control populations to understand differences in rates and trajectories.
A key aim is to strengthen and refine GWI case definitions by leveraging additional epidemiological evidence on symptom onset, duration, frequency, severity, progression, and relevant laboratory findings. While GWI symptoms vary across individuals, the announcement highlights a generally consistent symptom spectrum, often involving widespread pain and headaches, persistent fatigue, cognitive difficulties, gastrointestinal problems, and skin abnormalities. Projects can be hypothesis-driven (testing specific proposed relationships) or discovery-based (identifying previously unrecognized patterns), but they must stay anchored in rigorous epidemiological characterization of the Gulf War veteran population.
The funding announcement identifies several topic areas of interest. These include studying mortality rates and causes of death; building detailed descriptors of GWI symptomatology and how symptoms change over time; examining clinical diagnoses and lab findings associated with GWI; analyzing symptom clustering to identify subgroups within the broader GWI population; and evaluating gender and racial differences in outcomes and symptom patterns. The opportunity also notes gaps flagged in the April 2014 Research Advisory Committee on Gulf War Veterans' Illnesses report, including evidence that certain exposure groups (such as veterans exposed to nerve agent releases and oil well fires) show elevated brain cancer mortality. Beyond that, it emphasizes that comparatively little research has mapped Gulf War veterans' rates of other potentially relevant conditions, such as neurological disorders (for example multiple sclerosis or Parkinson's disease), other cancers, sleep disorders, adverse pregnancy outcomes, or birth defects in veterans' children. Applicants may propose studies on co-occurring conditions or offspring outcomes, but the primary emphasis must remain on epidemiological characterization of the veteran population rather than shifting the project into a different main focus.
The program signals a preference for studies that can inform broad populations and provide meaningful comparative insights across one or more of the identified topic areas. Proposals focused on smaller cohorts, narrow catchment areas, specific units, limited deployment geographies, or restricted sets of symptoms/markers are not excluded, but they must clearly justify why the scope is necessarily constrained and why the resulting findings would still be valuable and generalizable. One example of an acceptable justification is revisiting previously studied cohorts to extend or generate longitudinal data, which aligns with the award's interest in changes and progression over time.
Administratively, the opportunity was posted May 14, 2015, with an original and final closing date of October 29, 2015, and an archive date of November 28, 2015. It anticipated funding a single award (ExpectedAwards: 1) with an estimated total funding amount of $1.6 million, and it did not require cost sharing or matching. The eligible applicant pool was listed as unrestricted (open to any entity type, subject to any additional eligibility clarifications in the full announcement). The activity falls under CFDA 12.420, Military Medical Research and Development, and supports science and technology research and development activities. For access issues, the announcement directed applicants to the CDMRP Help Desk at 301-682-5507.
FAQs: DoD Gulf War Illness Epidemiology Research Award (GWIERA) (FY2015)
What is the DoD Gulf War Illness Epidemiology Research Award (GWIERA)?
The Gulf War Illness Epidemiology Research Award (GWIERA) is a FY2015 grant and cooperative agreement opportunity from the Department of the Army (USAMRAA) under the Gulf War Illness Research Program. It was offered for the first time in FY15 and is intended to support population-based epidemiology studies focused on Gulf War Illness (GWI) among veterans who deployed during the 1990-1991 Persian Gulf War.
What is the overall purpose of this award?
The award is designed to deepen understanding of how Gulf War Illness has affected deployed veterans over time by characterizing long-term patterns of mortality, morbidity, and symptom profiles, and by comparing these patterns to appropriate control populations to understand differences in rates and trajectories.
Who is the population of interest for GWIERA studies?
The primary population of interest is veterans who deployed during the 1990-1991 Persian Gulf War, with an emphasis on understanding outcomes and symptom patterns as they have evolved over time.
What types of studies does GWIERA fund?
GWIERA funds population-based epidemiology studies. Projects may be hypothesis-driven (testing specific proposed relationships) or discovery-based (identifying previously unrecognized patterns), but they must remain anchored in rigorous epidemiological characterization of the Gulf War veteran population.
Is this opportunity focused on long-term outcomes?
Yes. A central emphasis is on long-term patterns and how outcomes have changed over time, including progression and trajectories for mortality, morbidity, and symptom profiles.
Does the program require comparison groups or controls?
Yes. The announcement emphasizes comparing patterns observed in affected veterans against appropriate control populations to understand differences in rates and trajectories.
What are the main research topic areas highlighted in the announcement?
Topic areas of interest include: mortality rates and causes of death; detailed descriptors of GWI symptomatology and how symptoms change over time; clinical diagnoses and laboratory findings associated with GWI; symptom clustering to identify subgroups within the broader GWI population; and evaluating gender and racial differences in outcomes and symptom patterns.
How does GWIERA relate to Gulf War Illness case definitions?
A key aim is to strengthen and refine GWI case definitions by using additional epidemiological evidence on symptom onset, duration, frequency, severity, progression, and relevant laboratory findings.
What symptom spectrum does the announcement associate with Gulf War Illness?
While symptoms vary across individuals, the announcement notes a generally consistent spectrum often including widespread pain and headaches, persistent fatigue, cognitive difficulties, gastrointestinal problems, and skin abnormalities.
Can applicants study symptom subgroups within Gulf War Illness?
Yes. The announcement explicitly includes analyzing symptom clustering to identify subgroups within the broader GWI population as a topic area of interest.
Are gender and racial differences in outcomes within scope?
Yes. Evaluating gender and racial differences in outcomes and symptom patterns is specifically identified as a topic area of interest.
Does the opportunity mention specific exposure groups of interest?
Yes. It references gaps highlighted in the April 2014 Research Advisory Committee on Gulf War Veterans' Illnesses report, including evidence that certain exposure groups (such as veterans exposed to nerve agent releases and oil well fires) show elevated brain cancer mortality.
Are studies on cancers and neurological disorders relevant to this award?
The announcement notes that comparatively little research has mapped Gulf War veterans' rates of other potentially relevant conditions, including neurological disorders (for example, multiple sclerosis or Parkinson's disease) and other cancers, and it identifies these as areas where additional epidemiological mapping could be important.
Can a project focus on sleep disorders or other co-occurring conditions?
Applicants may propose studies on co-occurring conditions (including sleep disorders), but the primary emphasis must remain on epidemiological characterization of the Gulf War veteran population rather than shifting the project into a different main focus.
Can projects include adverse pregnancy outcomes or birth defects in veterans' children?
Yes, studies on adverse pregnancy outcomes or birth defects in veterans' children may be proposed, but the announcement states that the primary emphasis must remain on epidemiological characterization of the veteran population.
Are small cohort or narrowly scoped studies allowed?
They are not excluded, but proposals focused on smaller cohorts, narrow catchment areas, specific units, limited deployment geographies, or restricted sets of symptoms/markers must clearly justify why the scope is necessarily constrained and why findings would still be valuable and generalizable.
Is there an example of an acceptable justification for a constrained scope?
Yes. One example given is revisiting previously studied cohorts to extend or generate longitudinal data, aligning with the award's interest in changes and progression over time.
Does the award prefer studies that can inform broader populations?
Yes. The program signals a preference for studies that can inform broad populations and provide meaningful comparative insights across one or more of the identified topic areas.
How many awards were expected under this opportunity?
The opportunity anticipated a single award (ExpectedAwards: 1).
What was the estimated total funding amount?
The estimated total funding amount was $1.6 million.
Was cost sharing or matching required?
No. The announcement indicated that cost sharing or matching was not required.
Who was eligible to apply?
The eligible applicant pool was listed as unrestricted (open to any entity type), subject to any additional eligibility clarifications in the full announcement.
What agency and program administered the opportunity?
The opportunity was from the Department of the Army (USAMRAA) under the Gulf War Illness Research Program.
What is the CFDA number associated with this opportunity?
The activity falls under CFDA 12.420, Military Medical Research and Development.
What type of activity does CFDA 12.420 support in this context?
The announcement describes the activity as supporting science and technology research and development.
When was the opportunity posted?
The opportunity was posted on May 14, 2015.
What were the closing dates for submissions?
The original and final closing date listed was October 29, 2015.
When was the opportunity archived?
The archive date was November 28, 2015.
Where could applicants get help with access issues?
For access issues, applicants were directed to the CDMRP Help Desk at 301-682-5507.
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