Opportunity Information: Apply for W81XWH 09 GWIRP IIRA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Gulf War Investigator Initiated Research Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Apr 21, 2009 and posted on Apr 21, 2009.
  • Applicants must submit their applications by Sep 9, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,800,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 09 GWIRP IIRA

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Opportunity Summary:

The DoD Gulf War Illness Research Program (GWIRP) Investigator Initiated Research Award (IIRA) is a Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA) funding opportunity that supports investigator-driven studies focused on Gulf War Illness (GWI). The purpose is to advance the field in practical, clinically meaningful ways by improving how GWI is diagnosed and by clarifying the underlying biology (pathobiology) that may explain the persistent, complex symptom patterns reported by ill Gulf War veterans. The mechanism is meant to encourage fresh approaches and new ideas, including basic science and early-stage clinical or developmental research, as long as the work stays clearly centered on ill Gulf War veterans and the unique features of GWI.

A central goal of the program is to move beyond purely symptom-based descriptions and toward objective measures that can reliably distinguish ill veterans from healthy veterans. In practice, that means proposals aiming to identify or validate biomarkers and other measurable indicators tied to biological processes in GWI, or proposals that help reveal treatment targets by explaining what systems are disrupted and how. The announcement also accepts studies that examine the long-term (chronic) effects of neurotoxic exposures associated with Gulf War service, provided the exposure modeling is relevant and comparable in dosage to what veterans may have encountered. Overall, the opportunity is positioned to strengthen diagnostic testing and deepen understanding of mechanisms, with the longer-term implication that better biological clarity can support better clinical decision-making and therapeutic development.

The program highlights specific scientific areas of interest where objective indicators could be particularly informative. These include central nervous system structure and function, central neuroinflammatory processes, neuroendocrine measures, autonomic nervous system function, immune parameters, indicators of chronic infection, gastrointestinal complaints and symptoms, and genetic/genomic, proteomic, or metabolic characteristics. Applicants can approach these topics from different angles (for example, mechanistic studies, translational work, or clinically oriented developmental projects), but the unifying expectation is that the research will yield measurable insight into what differentiates GWI biologically and how those differences could be used for diagnosis or to guide treatment strategies.

A notable feature of the IIRA mechanism is that preliminary data are not required. Applicants may include preliminary data if it strengthens the proposal, and that data does not have to come from prior GWI research specifically. For proposals without preliminary data, the program emphasizes the need for a strong scientific rationale; these applications may be grounded in clinical observations or may test whether discoveries made in other chronic multi-symptom illnesses also apply to GWI. Regardless of the approach, the work should remain firmly focused on Gulf War veterans who are ill and on questions that meaningfully advance the understanding or measurement of GWI.

Administratively, this opportunity was posted April 21, 2009, with an original and current closing date of September 9, 2009, and an archive date of October 9, 2009. It is listed under Funding Opportunity Number W81XWH 09 GWIRP IIRA and CFDA 12.420 (Military Medical Research and Development). The funding instrument type allows for either a grant or cooperative agreement, there is no cost-sharing or matching requirement, eligibility is listed as unrestricted (open to any type of entity, subject to any additional clarifications in the full text), and the program anticipated making about three awards with an estimated total funding level of $2.8 million. For access or submission system issues, the announcement provides help contacts through the CDMRP support channels (PA HELP and eReceipt HELP).

Frequently Asked Questions (FAQs)

What is the GWIRP Investigator Initiated Research Award (IIRA)?

The Gulf War Illness Research Program (GWIRP) Investigator Initiated Research Award (IIRA) is a funding opportunity managed by the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA). It supports investigator-driven studies focused on Gulf War Illness (GWI).

What is the main purpose of this funding opportunity?

The purpose is to advance Gulf War Illness research in practical, clinically meaningful ways by improving how GWI is diagnosed and by clarifying the underlying biology (pathobiology) that may explain persistent, complex symptom patterns reported by ill Gulf War veterans.

What kind of research does the IIRA mechanism encourage?

The IIRA is designed to encourage fresh approaches and new ideas. It can support basic science research as well as early-stage clinical or developmental research, as long as the work stays clearly centered on ill Gulf War veterans and the unique features of GWI.

Is the program focused on symptoms or objective measures?

A central goal is to move beyond purely symptom-based descriptions and toward objective measures that can reliably distinguish ill veterans from healthy veterans. This includes work to identify or validate biomarkers or other measurable indicators tied to biological processes in GWI.

What types of outcomes is the program hoping to support?

The opportunity is positioned to strengthen diagnostic testing and deepen understanding of biological mechanisms. By improving biological clarity, the program aims to support better clinical decision-making and to inform therapeutic development over the longer term.

Are biomarker studies allowed or encouraged?

Yes. Proposals aiming to identify or validate biomarkers and other measurable indicators connected to biological processes in GWI are within the intent of the announcement.

Can research focus on treatment targets, even if it is not a treatment trial?

Yes. Studies that reveal potential treatment targets by explaining what systems are disrupted in GWI and how they are disrupted are described as responsive to the program goals.

Are studies on neurotoxic exposures associated with Gulf War service allowed?

Yes. The announcement accepts studies examining long-term (chronic) effects of neurotoxic exposures associated with Gulf War service, provided the exposure modeling is relevant and comparable in dosage to what veterans may have encountered.

What scientific areas of interest are highlighted in the announcement?

The program highlights areas where objective indicators could be particularly informative, including:

  • Central nervous system structure and function
  • Central neuroinflammatory processes
  • Neuroendocrine measures
  • Autonomic nervous system function
  • Immune parameters
  • Indicators of chronic infection
  • Gastrointestinal complaints and symptoms
  • Genetic/genomic, proteomic, or metabolic characteristics

Does an application need to fit only one scientific area of interest?

The announcement lists specific areas of interest, but applicants may approach these topics from different angles (mechanistic, translational, or clinically oriented developmental projects). The unifying expectation is that the research yields measurable insight into what differentiates GWI biologically and how those differences could be used for diagnosis or to guide treatment strategies.

Is preliminary data required to apply?

No. A notable feature of the IIRA mechanism is that preliminary data are not required.

Can preliminary data be included if available?

Yes. Applicants may include preliminary data if it strengthens the proposal.

Does preliminary data have to come from prior Gulf War Illness research?

No. The announcement notes that preliminary data does not have to come from prior GWI research specifically.

If preliminary data are not included, what does the program expect?

For proposals without preliminary data, the program emphasizes the need for a strong scientific rationale. These applications may be grounded in clinical observations or may test whether discoveries made in other chronic multi-symptom illnesses also apply to GWI.

Who or what must the research remain focused on?

Regardless of approach, the work should remain firmly focused on Gulf War veterans who are ill and on questions that meaningfully advance the understanding or measurement of GWI.

Which agency is associated with this opportunity?

This is a Department of the Army opportunity administered through USAMRAA under the DoD Gulf War Illness Research Program (GWIRP).

What is the Funding Opportunity Number for this announcement?

The Funding Opportunity Number is W81XWH 09 GWIRP IIRA.

What CFDA number is associated with this grant?

The CFDA listing provided is 12.420 (Military Medical Research and Development).

What type of funding instrument will be used?

The funding instrument type allows for either a grant or a cooperative agreement.

Is cost sharing or matching required?

No. The announcement states there is no cost-sharing or matching requirement.

Who is eligible to apply?

Eligibility is listed as unrestricted, meaning it is open to any type of entity, subject to any additional clarifications in the full text of the opportunity.

How many awards were anticipated under this opportunity?

The program anticipated making about three awards.

What was the estimated total funding level?

The estimated total funding level listed is $2.8 million.

When was the opportunity posted?

The opportunity was posted on April 21, 2009.

What was the closing date for applications?

The original and current closing date listed is September 9, 2009.

What is the archive date of the opportunity?

The archive date listed is October 9, 2009.

Where can applicants get help with access or submission system issues?

The announcement directs applicants to CDMRP support channels for technical help, including PA HELP and eReceipt HELP.

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