DoD Lung Cancer Clinical Exploration Award | Apply Online

Opportunity Summary:

The DoD Lung Cancer Clinical Exploration Award (CEA) is a Department of Defense Lung Cancer Research Program funding opportunity designed to jump-start early, proof-of-principle clinical work that could meaningfully change how lung cancer is managed. Introduced for the first time in fiscal year 2013, the program is aimed at supporting hypothesis-driven, innovative clinical interventions and the correlative studies that help explain why an intervention works (or does not work). The larger goal is to tackle persistent clinical roadblocks in lung cancer care by backing ideas that are creative, high-impact, and grounded in a clear scientific rationale, with the expectation that successful results will justify and enable larger, later-stage efficacy trials.

A central theme of this award is testing "outside the box" approaches in real clinical settings, but at an early stage where feasibility, safety signals, biological activity, and early evidence of potential benefit can be assessed. Proposed therapeutic strategies must be novel in the context of lung cancer, yet they do not have to be entirely new to medicine. The opportunity explicitly allows investigators to repurpose therapies that are already used clinically or currently being evaluated for other diseases, as long as the proposed lung cancer application is truly innovative and could represent a major step forward in treatment. This creates space for rapid translation of promising concepts into lung cancer trials, rather than limiting applicants only to brand-new compounds or technologies.

The CEA specifically supports early-phase clinical trials, including Phase 0, Phase I, and pilot Phase II studies. Eligible trial types include evaluations of drugs or drug combinations, studies involving Class II or Class III medical devices, and other early clinical testing efforts that explore novel approaches to lung cancer. The emphasis is on clinical exploration rather than large confirmatory studies, meaning the award is intended to generate the kind of initial human data and accompanying mechanistic insights that can later support a well-powered, efficacy-focused clinical trial program.

From an administrative and funding perspective, this is a discretionary Department of the Army opportunity administered through USAMRAA (U.S. Army Medical Research Acquisition Activity) under the Military Medical Research and Development CFDA listing (12.420). The funding instrument is listed as a cooperative agreement or grant, with an expected number of awards of one and an estimated total funding amount of $720,000. There is no cost-sharing or matching requirement noted. Eligibility is described as unrestricted, meaning any type of entity may apply, subject to any additional eligibility clarifications contained in the full announcement.

The program also signals a strong interest in collaborations tied to military and veteran health systems. Submissions from, and partnerships with, investigators at Military Medical Treatment Facilities, military laboratories, and Department of Veterans Affairs (VA) Medical Centers and research labs are encouraged. This reflects the DoD focus on leveraging the military and VA research and clinical infrastructure, and it may also align the funded work with populations and care settings relevant to service members and veterans.

Key dates for the FY13 announcement include a posted and creation date of May 21, 2013, with an original and current closing date of October 16, 2013, and an archive date of November 15, 2013. The funding opportunity number is W81XWH-13-LCRP-CEA, and the title is "DoD Lung Cancer Clinical Exploration Award." For applicants who could not access the full announcement electronically, the notice provided a point of contact through the CDMRP Help Desk at 301-682-5507.

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