DOD Lung Cancer Early Detection Clinical Consortium Award | Apply Online

Opportunity Summary:

The DOD Lung Cancer Early Detection Clinical Consortium Award (Funding Opportunity Number W81XWH-10-LCRP-LCEDCC) is a Fiscal Year 2010 funding opportunity from the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), under the Lung Cancer Research Program (LCRP). It is a discretionary, science and technology/research and development award made as a cooperative agreement, meaning the government expects to have substantial involvement during the project period rather than operating strictly as a hands-off grant. This mechanism was offered for the first time in FY2010 and is aimed specifically at supporting clinical research that can improve how lung cancer is detected early, with the larger goal of improving patient outcomes.

The core purpose of the award is to fund clinical studies that characterize, develop, and/or improve early detection modalities for lung cancer. In practice, this is meant to move beyond basic discovery and focus on patient-centered research that can generate evidence strong enough to influence real-world screening or diagnostic approaches. The program emphasizes building a multi-institutional clinical consortium that intentionally links military and civilian capabilities: it seeks to bring together (1) military beneficiaries who are at high risk for developing lung cancer and lung cancer patients treated at specified military treatment facilities (MTFs) and (2) the patient populations, specialized tools, and scientific expertise available at strong civilian research organizations. A major expected outcome is not just study results, but also the creation of a durable clinical infrastructure for an ongoing early detection program that can continue beyond the end of the award.

Projects proposed under this award are expected to be militarily relevant and methodologically rigorous. The announcement highlights several expectations that signal a focus on high-quality clinical evidence: proposals should have clear, well-defined objectives; they should control for confounding factors; and they should include access to a patient population large enough to deliver adequate statistical power. The studies should also be designed with an eye toward impact, specifically the likelihood of producing results that could change clinical practice for early detection of lung cancer. If any portion of the work involves non-military patient populations, applicants must explicitly explain how those populations and findings relate back to the targeted communities, namely Armed Forces members and/or the U.S. veteran population.

The allowable scope is limited strictly to clinical research and clinical trials, including multi-site consortium studies that may range from small randomized or pilot clinical trials to large randomized clinical trials. Preclinical work is not the focus here, and animal studies are explicitly excluded from consideration. In other words, the award is built for investigators who are ready to test or validate early detection strategies in humans, within a structured clinical consortium setting, and with enough scale and rigor to yield clinically meaningful conclusions.

From an administrative standpoint, the opportunity anticipated a single award, with an estimated total funding amount of $13,500,000 and no cost sharing or matching requirement. Eligibility was listed as unrestricted (open to any type of entity), subject to any additional eligibility clarifications contained in the full announcement. The opportunity was posted on September 3, 2010, with an original and final closing date of December 7, 2010, and an archive date of January 6, 2011. The CFDA listing associated with the program is 12.420 (Military Medical Research and Development). For assistance, the announcement provided contacts for accessing the full posting (PA HELP at 301-619-7079 or cdmrp.pa@amedd.army.mil) and for electronic submission support (eReceipt HELP at 301-682-5507 or help@cdmrp.org), along with the CDMRP Help Desk.

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Previous opportunity: Cooperative Agreement, NPS/MTFWP

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