Opportunity Information: Apply for W81XWH 15 MBRP BIRA
Apply for W81XWH 15 MBRP BIRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Military Burn Injuries Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Jun 30, 2015 and posted on Jun 30, 2015.
- Applicants must submit their applications by Dec 3, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $8,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Military Burn Injuries Research Award (BIRA) is a funding opportunity from the Department of the Army (USAMRAA) under the Military Burn Research Program (MBRP) that was introduced for the first time in FY2015. Its purpose is to support research that directly advances the treatment of traumatic burn injuries in ways that matter to military personnel, with an emphasis on work that can move beyond concept-level science toward realistic solutions that could be tested in people. The program is designed to accelerate development of practical medical products, approaches, or technologies that could improve outcomes for service members affected by burn trauma.
A central point of this opportunity is that it does not fund fundamental basic research. In the terms used in the announcement, basic research is work aimed at expanding general knowledge about biological or physical phenomena without a clear, specific application leading toward a process or product. Instead, this award targets applied research, meaning studies that refine concepts into potential solutions, evaluate technical feasibility, and generate evidence needed to justify and prepare for initial human testing. That makes the award especially relevant for teams that already have a promising intervention or technology and need support to mature it through key translational steps like preclinical testing, feasibility work, and early clinical evaluation.
Applicants are required to include preliminary data, and the program expects investigators to demonstrate logical, evidence-based reasoning. Competitive proposals must present a strong scientific rationale and a well-formed, testable hypothesis grounded in a critical review of existing literature, supported by preliminary and/or published data that directly connects to the research question. In other words, the award is not structured for speculative early ideas; it is meant for projects with enough existing evidence to justify a focused development plan and clear next steps toward clinical use.
Clinical trials are allowed under this mechanism, and the announcement explicitly contemplates early human testing for promising pharmaceuticals, biologics, and medical devices or technologies. The opportunity uses a standard definition of a clinical trial: a prospective study in which human subjects are accrued and an intervention is tested to measure outcomes related to exploratory findings, safety, effectiveness, and/or efficacy, where the outcome reflects a direct effect of the intervention on the participant. The scope permits Phase I or early Phase II trials (often described as Phase IIa), but it does not support late Phase II, Phase III, large-scale effectiveness trials, or advanced development beyond these early stages. It also references additional guidance for human subjects research through a Human Subject Resource Document hosted on eBRAP.
In terms of project types, the award supports a wide range of translational and clinical activities, from smaller studies up to larger efforts, as long as they remain aligned with early-stage clinical readiness. Examples of work within scope include efficacy studies, comparative studies, human-use or observational studies, clinical trial development activities, and clinical trials themselves. The program highlights activities such as refining emerging approaches and technologies, evaluating and narrowing down candidate products (including in vitro and in vivo work), conducting preclinical safety and toxicity studies, and preparing materials or evidence needed for a future clinical trial or regulatory submission. The common thread is that projects should be positioned to produce tangible, testable deliverables that move a candidate intervention closer to real-world use in burn care.
From an administrative standpoint, the funding opportunity number is W81XWH-15-MBRP-BIRA, and it was offered as grants and cooperative agreements under CFDA 12.420 (Military Medical Research and Development). The opportunity was posted on June 30, 2015, with an application closing date of December 3, 2015, and an estimated total funding amount of $8,000,000 to support an expected four awards. Eligibility is listed as unrestricted, meaning the solicitation is generally open to many entity types, subject to any additional eligibility notes in the full announcement. No cost sharing or matching is required. For assistance accessing the full announcement, applicants were directed to the CDMRP Help Desk at 301-682-5507.
DoD Military Burn Injuries Research Award (BIRA) - FAQs
What is the DoD Military Burn Injuries Research Award (BIRA)?
The Military Burn Injuries Research Award (BIRA) is a Department of Defense funding opportunity administered by the Department of the Army (USAMRAA) under the Military Burn Research Program (MBRP). It was introduced for the first time in FY2015 to support research that directly advances treatment of traumatic burn injuries in ways that matter to military personnel.
What is the main purpose of this award?
The purpose is to accelerate development of practical medical products, approaches, or technologies that could improve outcomes for service members affected by burn trauma, with an emphasis on work that can move beyond concept-level science toward realistic solutions that could be tested in people.
What kind of research does BIRA fund (basic vs. applied)?
BIRA targets applied research and does not fund fundamental basic research. Applied research under this opportunity includes refining concepts into potential solutions, evaluating technical feasibility, and generating evidence needed to justify and prepare for initial human testing.
What does the solicitation mean by "basic research" that is not funded?
In the terms used in the announcement, basic research is work aimed at expanding general knowledge about biological or physical phenomena without a clear, specific application leading toward a process or product.
What stage of development is this award designed for?
This award is intended for projects that already have a promising intervention or technology and need support to mature it through translational steps such as preclinical testing, feasibility work, and early clinical evaluation, with the goal of moving closer to clinical use in burn care.
Are preliminary data required?
Yes. Applicants are required to include preliminary data, and the program expects logical, evidence-based reasoning tied to the proposed research question.
What makes a proposal competitive under BIRA?
Competitive proposals are expected to present a strong scientific rationale and a well-formed, testable hypothesis grounded in a critical review of existing literature, supported by preliminary and/or published data that directly connects to the research question.
Is BIRA appropriate for speculative or very early concepts?
No. The award is not structured for speculative early ideas; it is meant for projects with enough existing evidence to justify a focused development plan and clear next steps toward clinical use.
Are clinical trials allowed under this mechanism?
Yes. Clinical trials are allowed, and the announcement explicitly contemplates early human testing for promising pharmaceuticals, biologics, and medical devices or technologies.
How does the opportunity define a clinical trial?
The opportunity uses a standard definition: a clinical trial is a prospective study in which human subjects are accrued and an intervention is tested to measure outcomes related to exploratory findings, safety, effectiveness, and/or efficacy, where the outcome reflects a direct effect of the intervention on the participant.
What phases of clinical trials are within scope?
The scope permits Phase I or early Phase II trials (often described as Phase IIa).
What phases or types of trials are not supported?
The opportunity does not support late Phase II, Phase III, large-scale effectiveness trials, or advanced development beyond early Phase II/Phase IIa.
What kinds of project activities are supported?
The award supports translational and clinical activities aligned with early-stage clinical readiness. Examples include efficacy studies, comparative studies, human-use or observational studies, clinical trial development activities, and clinical trials.
What translational development work is specifically highlighted as within scope?
Highlighted activities include refining emerging approaches and technologies, evaluating and narrowing down candidate products (including in vitro and in vivo work), conducting preclinical safety and toxicity studies, and preparing materials or evidence needed for a future clinical trial or regulatory submission.
What is the common theme of the projects BIRA wants to support?
Projects should be positioned to produce tangible, testable deliverables that move a candidate intervention closer to real-world use in burn care and improve outcomes for service members affected by burn trauma.
Who is the awarding/administrating organization for this opportunity?
The funding opportunity is from the Department of the Army (USAMRAA) under the DoD Military Burn Research Program (MBRP).
What is the funding opportunity number?
The funding opportunity number is W81XWH-15-MBRP-BIRA.
Under what CFDA number is this opportunity listed?
It was offered as grants and cooperative agreements under CFDA 12.420 (Military Medical Research and Development).
When was the opportunity posted and when was it due?
The opportunity was posted on June 30, 2015, and the application closing date was December 3, 2015.
What was the estimated total funding amount and expected number of awards?
The estimated total funding amount was $8,000,000, with an expectation of four awards.
Is cost sharing or matching required?
No. No cost sharing or matching is required.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning the solicitation is generally open to many entity types, subject to any additional eligibility notes in the full announcement.
Where can applicants find additional guidance for human subjects research?
The announcement references additional guidance through a Human Subject Resource Document hosted on eBRAP.
Who should applicants contact for help accessing the full announcement?
For assistance accessing the full announcement, applicants were directed to the CDMRP Help Desk at 301-682-5507.
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