Opportunity Information: Apply for W81XWH 12 MSRP IA
Apply for W81XWH 12 MSRP IA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Multiple Sclerosis Research Program" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Mar 15, 2012 and posted on Mar 15, 2012.
- Applicants must submit their applications by Jul 17, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,200,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The Department of Defense Multiple Sclerosis Research Program (MSRP) Idea Award (Funding Opportunity Number W81XWH-12-MSRP-IA) is a discretionary research funding opportunity managed through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed specifically to spark and support new, early-stage research ideas in multiple sclerosis (MS) that are not yet fully developed but have a realistic chance of producing major, field-shifting results. The program is looking for conceptually innovative projects that may be high risk but also potentially high reward, with the long-term goal of enabling critical discoveries about the causes and progression of MS and/or generating meaningful improvements in patient care and quality of life.
A central expectation of the Idea Award is that the proposed work is truly innovative rather than incremental. In this context, innovation means more than improving an existing approach or taking the next logical step. Competitive applications are expected to introduce a new paradigm, challenge widely held assumptions, or reframe an MS research problem from a fresh angle in a way that could open entirely new avenues of investigation. The funding mechanism explicitly signals that routine extensions of prior work or modest refinements are unlikely to be considered responsive, because the award is meant to catalyze bold ideas that could change how MS is understood or managed if they succeed.
Impact is another major emphasis. Proposed projects should be aimed at a central, critical scientific or clinical question in MS research, and reviewers will be looking for a clear line of sight between the proposed experiments and the potential to substantially advance MS knowledge or care. A high-impact project, as described in the announcement, is one that could significantly move the field forward and align with the broader MSRP vision, rather than generating narrow or purely confirmatory findings. In practical terms, strong applications typically make a compelling case for why the problem matters, why it remains unsolved, and how the proposed approach could deliver a meaningful leap forward.
While the award encourages boldness, it also requires a sound scientific foundation. Applications must include a well-formulated, testable hypothesis supported by strong scientific rationale. In addition, preliminary data are expected, which can include unpublished results from the principal investigator or named collaborators, or relevant findings drawn from the published literature. The intent is to show that, even though the idea may be unconventional and carries risk, it is still grounded in logic, evidence, and a thoughtful analysis of what is known. The program acknowledges that groundbreaking research can encounter unforeseen obstacles, but it expects applicants to demonstrate that the concept is credible and that the proposed work is designed in a way that can realistically evaluate the hypothesis.
From an administrative and funding standpoint, this opportunity was posted March 15, 2012, with an original and current closing date of July 17, 2012, and an archive date of August 16, 2012. The total estimated funding listed is $3.2 million, with an expected five awards. The funding instrument types include cooperative agreements and grants, and it falls under CFDA 12.420 (Military Medical Research and Development). No cost sharing or matching is required. Eligibility is described as unrestricted, meaning it is broadly open to applicants of any entity type, subject to any additional eligibility clarifications that may appear in the full announcement. For access issues or assistance with the announcement, the listed point of contact is the CDMRP Help Desk at 301-682-5507.
Frequently Asked Questions (FAQs) - DoD Multiple Sclerosis Research Program (MSRP) Idea Award
What is the MSRP Idea Award?
The Department of Defense Multiple Sclerosis Research Program (MSRP) Idea Award is a discretionary research funding opportunity intended to spark and support new, early-stage research ideas in multiple sclerosis (MS). It is aimed at conceptually innovative projects that are not yet fully developed but have a realistic chance of producing major, field-shifting results.
What is the Funding Opportunity Number for this award?
The Funding Opportunity Number (FON) is W81XWH-12-MSRP-IA.
Which agency manages this grant opportunity?
This opportunity is managed through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Department of Defense Multiple Sclerosis Research Program (MSRP).
What is the main goal of the Idea Award?
The long-term goal is to enable critical discoveries about the causes and progression of MS and/or generate meaningful improvements in patient care and quality of life. The award specifically aims to catalyze bold ideas that could change how MS is understood or managed if they succeed.
What kind of research projects is the program looking for?
The program is looking for conceptually innovative MS research projects that may be high risk but potentially high reward. Competitive proposals are expected to introduce a new paradigm, challenge widely held assumptions, or reframe an MS research problem from a fresh angle in a way that could open new avenues of investigation.
What does "innovation" mean for this funding opportunity?
In this context, innovation means more than improving an existing approach or taking the next logical step. The opportunity emphasizes truly innovative ideas rather than incremental progress. Routine extensions of prior work or modest refinements are described as unlikely to be considered responsive to the intent of this award.
Are incremental or confirmatory studies a good fit for the Idea Award?
Based on the program description, incremental projects, routine extensions of prior work, modest refinements, or narrowly confirmatory studies are unlikely to align with the purpose of the Idea Award, which is designed to catalyze bold, field-shifting ideas.
What is the program looking for in terms of "impact"?
Impact is a major emphasis. Proposed projects should address a central, critical scientific or clinical question in MS research and show a clear line of sight from the proposed experiments to the potential to substantially advance MS knowledge or care. Strong applications typically explain why the problem matters, why it remains unsolved, and how the proposed approach could deliver a meaningful leap forward.
Does the Idea Award allow high-risk research?
Yes. The program encourages bold, conceptually innovative projects that may be high risk, provided they are also potentially high reward and have a realistic chance of producing major results if successful.
What scientific requirements are expected in an application?
Applications are expected to include a well-formulated, testable hypothesis supported by strong scientific rationale. Even though the program supports unconventional ideas, applicants are expected to demonstrate that the concept is credible and that the work is designed in a way that can realistically evaluate the hypothesis.
Is preliminary data required?
Yes. Preliminary data are expected. The announcement notes that preliminary data can include unpublished results from the principal investigator or named collaborators, or relevant findings drawn from the published literature.
Can preliminary data come from collaborators or published literature?
Yes. The program indicates that preliminary data may include unpublished results from the principal investigator or named collaborators, as well as relevant findings from the published literature.
How does the program balance bold ideas with feasibility?
While groundbreaking research can encounter unforeseen obstacles, the program expects proposals to be grounded in logic, evidence, and thoughtful analysis of what is known, with a credible concept and a study design capable of realistically testing the hypothesis.
When was this funding opportunity posted?
The opportunity was posted on March 15, 2012.
What is the application closing date?
The original and current closing date listed is July 17, 2012.
Is this opportunity still open?
The information provided lists a closing date of July 17, 2012 and an archive date of August 16, 2012, indicating it is not currently open based on the dates shown.
What is the archive date?
The archive date listed is August 16, 2012.
How much total funding is estimated for this opportunity?
The total estimated funding amount listed is $3.2 million.
How many awards are expected to be made?
The opportunity states an expected five awards.
What types of funding instruments are used?
The funding instrument types include cooperative agreements and grants.
What is the CFDA number associated with this program?
The CFDA number listed is 12.420 (Military Medical Research and Development).
Is cost sharing or matching required?
No. The opportunity states that no cost sharing or matching is required.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to applicants of any entity type, subject to any additional eligibility clarifications that may appear in the full announcement.
Where can applicants get help or report access issues?
For access issues or assistance with the announcement, the listed point of contact is the CDMRP Help Desk at 301-682-5507.
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