DOD Neurofibromatosis Exploration Hypothesis Development Award | Apply Online

Opportunity Summary:

The DOD Neurofibromatosis Exploration - Hypothesis Development Award (EHDA) is a Department of the Army/USAMRAA funding opportunity under the Neurofibromatosis Research Program (NFRP) intended to jump-start early, idea-driving research in neurofibromatosis and/or schwannomatosis. The purpose is to give investigators room to test innovative and largely unproven concepts that are high risk but could produce high-impact breakthroughs. Projects supported by this mechanism are expected to generate the kind of initial evidence or conceptual framework that can either form the scientific rationale for a new hypothesis or establish the first principles behind an unconventional hypothesis. In practice, this means the award is positioned as an entry point for novel directions rather than a mechanism for mature, heavily validated research programs.

A defining feature of the EHDA is its openness to exploratory work, including lines of inquiry that may stem from unexpected or serendipitous observations. The program explicitly recognizes that, at this early stage, applicants may not be able to supply a complete body of supporting literature or prior results, and it tolerates some gaps in rationale due to limited available information. While preliminary data are encouraged because they can strengthen feasibility and credibility, they are not required, which signals that reviewers are expected to weigh innovation and potential significance heavily alongside feasibility. At the same time, the burden is on the Principal Investigator to make a clear, explicit case for why the proposed research is genuinely innovative and how the idea is novel relative to existing work in the field.

Administratively, this opportunity was posted February 2, 2009, under Funding Opportunity Number W81XWH-09-NFRP-EHDA, with an application deadline of April 14, 2009, and an archive date of May 14, 2009. The funding instrument type is listed as a cooperative agreement and/or grant, and the activity category is Science and Technology and other Research and Development. The program anticipated making about three awards, with an estimated total funding pool of $450,000, and it did not require cost sharing or matching funds. Eligibility was described as unrestricted, meaning it was broadly open to different types of applicant organizations, subject to any additional clarifications in the full announcement.

The program also provided context on the award mechanism's track record up to that point: first offered in FY08, it had received 21 applications, with 6 recommended for funding. That history suggests the mechanism was competitive and selective, likely emphasizing standout novelty and transformative potential rather than incremental advances. For applicants, the central takeaway is that a strong EHDA application would focus on a bold, testable concept in neurofibromatosis and/or schwannomatosis, explain why the idea could change understanding or practice if it works, and lay out an approach designed to yield interpretable early evidence even if the starting premise is unconventional.

For assistance, the announcement listed support contacts for accessing the full posting and for submission-system help, including PA HELP at 301-619-7079 (cdmrp.pa@amedd.army.mil), eReceipt HELP at 301-682-5507 (help@cdmrp.org), and the CDMRP Helpdesk.

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