Opportunity Information: Apply for W81XWH 10 NFRP IIFRA
Apply for W81XWH 10 NFRP IIFRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Investigator Initiated Focused Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Feb 23, 2010 and posted on Feb 23, 2010.
- Applicants must submit their applications by May 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Neurofibromatosis Research Program (NFRP) Investigator Initiated Focused Research Award (IIFRA) is a FY2010 funding opportunity from the Department of the Army (USAMRAA) designed to support targeted, investigator-driven research on neurofibromatosis (NF) and/or schwannomatosis. This mechanism was offered for the first time in FY10 and is intended to fund projects that are tightly aligned to specific priority topics rather than broad, exploratory work. The program is positioned within the Military Medical Research and Development CFDA (12.420) and uses assistance instruments such as grants and cooperative agreements.
Projects submitted under this award must directly address at least one of the designated research focus areas: pain, wound repair, nerve regeneration, stress and inflammation, cognitive dysfunction, health-related quality of life, or the neurofibromin protein. In other words, proposals need to clearly map their aims and outcomes to one or more of these subjects and explain why the work is relevant to NF and/or schwannomatosis. A key requirement is that applications include preliminary data that come from the principal investigator (PI), the research team, or a collaborator, and that these data are relevant both to NF and to the proposed studies. This makes the award more suitable for teams that already have early evidence supporting feasibility and rationale, rather than teams starting from scratch.
Human subjects research is allowed under this opportunity, but clinical trials are explicitly not permitted. The announcement uses a standard definition of a clinical trial as a prospective human study in which an intervention (such as a drug, device, behavioral approach, surgical procedure, or other intervention) is tested to measure an outcome. Applicants who want to run a clinical trial are directed to use a separate Clinical Trial Award mechanism instead. The guidance also notes that applicants should consult the program’s general application instructions (including Appendix 5) for expectations around studies involving human subjects, human subjects data, or human anatomical substances, signaling that human research protections and proper regulatory handling are important even when the work does not meet the definition of a clinical trial.
The program strongly encourages meaningful collaboration, especially partnerships that bridge basic science and clinical research or connect academia with biotechnology/pharmaceutical industry scientists. Collaborations that bring in new disciplines or new investigators to the NF field are also encouraged. Importantly, the announcement describes an optional “qualified collaborator” approach that can make an application eligible for a higher funding level (as described in the full announcement). To qualify for that higher level, the PI must include a Statement of Collaboration identifying the collaborator and explaining how the collaboration meets the program’s criteria, and the collaborator must provide a letter describing their role. The collaboration must be genuinely interdependent: the collaborator must contribute in a way that is essential to completing the work, not simply providing samples or access to patients. The collaborator must be at least an Assistant Professor (or equivalent), must commit at least 10 percent level of effort, and that effort must be reflected in the project budget.
From an administrative standpoint, the opportunity number is W81XWH-10-NFRP-IIFRA. It was posted and created on February 23, 2010, with an original and final closing date of May 20, 2010, and an archive date of June 19, 2010. The program anticipated making about three awards, with an estimated total funding amount of $3,000,000, and it did not require cost sharing or matching. Eligibility is listed as unrestricted (open to any entity type), subject to any additional eligibility clarifications in the full announcement. For applicant support, the notice provides contacts for announcement access issues (PA HELP) and for electronic submission support (eReceipt/CDMRP Help Desk).
FAQs: DoD Neurofibromatosis Research Program (NFRP) Investigator Initiated Focused Research Award (IIFRA) - FY2010
What is the NFRP Investigator Initiated Focused Research Award (IIFRA)?
The Investigator Initiated Focused Research Award (IIFRA) is a FY2010 funding opportunity under the DoD Neurofibromatosis Research Program (NFRP), managed by the Department of the Army (USAMRAA). It is designed to support targeted, investigator-driven research focused on neurofibromatosis (NF) and/or schwannomatosis.
What is the main purpose or intent of this award mechanism?
This mechanism is intended to fund projects that are tightly aligned with specific, designated priority topics. It is not intended for broad, exploratory, or loosely defined research. It was offered for the first time in FY2010.
What research topics are eligible under this opportunity?
Applications must directly address at least one of the designated research focus areas: pain, wound repair, nerve regeneration, stress and inflammation, cognitive dysfunction, health-related quality of life, or the neurofibromin protein.
Do proposals have to focus on neurofibromatosis and/or schwannomatosis specifically?
Yes. Proposals must clearly explain why the work is relevant to NF and/or schwannomatosis and must map the proposed aims and outcomes to one or more of the specified focus areas.
Is preliminary data required?
Yes. Applications must include preliminary data that are relevant to NF and to the proposed studies. The preliminary data may come from the principal investigator (PI), the research team, or a collaborator.
What does the preliminary data need to demonstrate?
Based on the requirements stated, the preliminary data must be relevant to NF and relevant to the proposed studies, supporting feasibility and rationale for the planned work.
Are human subjects studies allowed?
Yes. Human subjects research is allowed under this award opportunity.
Are clinical trials allowed under this award?
No. Clinical trials are explicitly not permitted under this announcement.
How does the announcement define a clinical trial?
A clinical trial is described as a prospective human study in which an intervention (such as a drug, device, behavioral approach, surgical procedure, or other intervention) is tested to measure an outcome.
What should an applicant do if they want to conduct a clinical trial?
Applicants who want to run a clinical trial are directed to use a separate Clinical Trial Award mechanism instead of this IIFRA opportunity.
Does the opportunity mention any specific expectations for human subjects materials or data?
Yes. The guidance notes that applicants should consult the program's general application instructions (including Appendix 5) for expectations around studies involving human subjects, human subjects data, or human anatomical substances.
Is collaboration encouraged?
Yes. The program strongly encourages meaningful collaboration, particularly collaborations that bridge basic science and clinical research, or partnerships connecting academia with biotechnology/pharmaceutical industry scientists.
Are collaborations that bring new disciplines or new investigators to NF encouraged?
Yes. Collaborations that introduce new disciplines or new investigators to the neurofibromatosis field are encouraged.
Is there an option to be eligible for a higher funding level through collaboration?
Yes. The announcement describes an optional "qualified collaborator" approach that can make an application eligible for a higher funding level (as described in the full announcement).
What documentation is required to use the "qualified collaborator" approach?
The PI must include a Statement of Collaboration that identifies the collaborator and explains how the collaboration meets the program's criteria. The collaborator must also provide a letter describing their role.
What makes a collaborator "qualified" under this opportunity?
The collaboration must be genuinely interdependent, meaning the collaborator's contribution must be essential to completing the work and not limited to simply providing samples or access to patients. The collaborator must be at least an Assistant Professor (or equivalent), must commit at least 10 percent level of effort, and that effort must be reflected in the project budget.
Can a collaborator qualify if they only provide samples or access to patients?
No. The announcement indicates that simply providing samples or access to patients is not sufficient. The collaborator must contribute in an essential, interdependent way to complete the project.
What is the opportunity number for this funding announcement?
The opportunity number is W81XWH-10-NFRP-IIFRA.
Which agency administers this opportunity?
The opportunity is associated with the Department of the Army via USAMRAA, within the DoD Neurofibromatosis Research Program (NFRP).
What CFDA program is this opportunity associated with?
It is positioned within the Military Medical Research and Development CFDA, 12.420.
What type of funding instruments are used for this opportunity?
The opportunity uses assistance instruments such as grants and cooperative agreements.
When was this opportunity posted, and what were the closing dates?
It was posted and created on February 23, 2010. The original and final closing date was May 20, 2010. The archive date was June 19, 2010.
How many awards were anticipated, and what was the estimated total funding?
The program anticipated making about three awards, with an estimated total funding amount of $3,000,000.
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching was not required.
Who is eligible to apply?
Eligibility is listed as unrestricted (open to any entity type), subject to any additional eligibility clarifications in the full announcement.
Where can applicants get help if they cannot access the announcement?
The notice provides a contact for announcement access issues: PA HELP.
Where can applicants get technical help with electronic submission?
The notice provides electronic submission support contacts through the eReceipt/CDMRP Help Desk.
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