Opportunity Information: Apply for W81XWH 14 NFRP IIRA
Apply for W81XWH 14 NFRP IIRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Investigator Initiated Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on May 27, 2014 and posted on May 27, 2014.
- Applicants must submit their applications by Jul 24, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $6,004,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Neurofibromatosis Research Program (NFRP) Investigator Initiated Research Award (IIRA) is a long-running funding mechanism (first offered in FY1996) designed to support investigator-driven projects that can meaningfully advance neurofibromatosis (NF) research and ultimately improve patient care. The program emphasizes highly rigorous, high-impact work, and it is intentionally broad in the kinds of research questions it will consider. Projects can span the full pipeline from basic discovery through translational research, including preclinical studies in animal models, studies involving human subjects or human specimens, and correlative studies tied to an existing clinical trial. The key restriction is that applicants may not propose a clinical trial under this particular award mechanism; investigators who want to run a clinical trial are directed to a separate NFRP Clinical Trial Award opportunity.
A central expectation of this opportunity is that proposals are grounded in evidence and designed for reproducibility. Applications must include preliminary and/or published data that directly relate to NF and to the proposed research plan, signaling that the program is looking for ideas with a credible foundation rather than purely speculative concepts. The announcement also places strong weight on rigorous study design and transparent reporting practices, referencing widely cited standards for improving the predictive value of preclinical research (including principles such as randomization, blinding, sample size estimation, and clear rules for data handling). Even though the cited guidance was written with preclinical research in mind, the program stresses that these basic practices reflect established research best practices and should be applied broadly where relevant.
For projects using animal models, the rigor requirements are especially explicit. Applicants must submit an Animal Research Plan (listed as Attachment 8 in the application package) explaining how they will implement and document these rigor elements. The announcement also encourages use of the ARRIVE guidelines (Animal Research Reporting In Vivo Experiments) so that animal studies are not only well planned but also reported in a way that supports interpretation, replication, and translation. For research involving human subjects or human anatomical substances, such work is allowed under the IIRA, and applicants are pointed to additional human-subject resources available through the electronic Biomedical Research Application Portal (eBRAP) to help clarify what is considered clinical research versus a clinical trial and to support compliant study planning.
From an administrative and funding standpoint, this opportunity was issued by the Department of the Army through USAMRAA under CFDA 12.420 (Military Medical Research and Development). The funding opportunity number is W81XWH-14-NFRP-IIRA, and the instrument types listed include both cooperative agreements and grants. The total estimated funding amount in the announcement is $6,004,000, with an expectation of about seven awards, and there is no cost-sharing or matching requirement. Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications included in the full announcement. Key dates for this posting were May 27, 2014 (posted/created) with an application closing date of July 24, 2014, and an archive date of August 23, 2014.
For practical access and support, applications and program materials are routed through eBRAP, and the announcement provides CDMRP Help Desk contact information for assistance (phone 301-682-5507; email help@eBRAP.org), particularly for applicants who have trouble accessing the full announcement online.
FAQs: DoD Neurofibromatosis Research Program (NFRP) Investigator Initiated Research Award (IIRA)
What is the NFRP Investigator Initiated Research Award (IIRA)?
The IIRA is a long-running Department of Defense Neurofibromatosis Research Program funding mechanism (first offered in FY1996) that supports investigator-driven projects intended to meaningfully advance neurofibromatosis (NF) research and ultimately improve patient care.
What is the main goal of this award?
The main goal is to fund highly rigorous, high-impact NF research that can move the field forward and support improvements in patient care. The mechanism is designed to accommodate a wide range of NF-focused research questions.
What types of research are eligible under this opportunity?
The IIRA is intentionally broad and can support projects across the full research pipeline, including basic discovery, translational research, preclinical studies in animal models, studies involving human subjects or human specimens, and correlative studies linked to an existing clinical trial.
Are clinical trials allowed under the IIRA?
No. A key restriction is that applicants may not propose a clinical trial under this award mechanism. Investigators who want to conduct a clinical trial are directed to a separate NFRP Clinical Trial Award opportunity.
Can a project include work related to an existing clinical trial?
Yes. Correlative studies tied to an existing clinical trial are specifically mentioned as an allowable type of work under this award, as long as the proposed work itself is not a clinical trial.
Is research involving human subjects or human specimens allowed?
Yes. Research involving human subjects or human anatomical substances is allowed under the IIRA. The opportunity points applicants to human-subject resources in eBRAP to help distinguish clinical research from a clinical trial and to support compliant study planning.
What is emphasized about scientific rigor and reproducibility?
The program places strong emphasis on proposals being evidence-based and designed for reproducibility. It highlights rigorous study design and transparent reporting practices, referencing principles commonly used to improve the predictive value of preclinical research.
What kinds of rigor practices are expected to be addressed in the application?
The announcement references best-practice elements such as randomization, blinding, sample size estimation, and clear rules for data handling. While the cited guidance was written with preclinical research in mind, the program indicates these practices should be applied broadly where relevant.
Is preliminary data required?
Yes. Applications must include preliminary and/or published data that directly relate to neurofibromatosis and to the proposed research plan, indicating the program is looking for proposals with a credible foundation rather than purely speculative concepts.
What additional requirements apply to projects using animal models?
For animal model projects, the rigor requirements are especially explicit. Applicants must submit an Animal Research Plan (Attachment 8 in the application package) describing how rigor elements will be implemented and documented.
Are any specific animal-study reporting guidelines recommended?
Yes. The announcement encourages the use of the ARRIVE guidelines (Animal Research Reporting In Vivo Experiments) to support well-planned studies and reporting that enables interpretation, replication, and translation.
Who is the issuing agency for this opportunity?
The opportunity was issued by the Department of the Army through USAMRAA under CFDA 12.420 (Military Medical Research and Development).
What is the funding opportunity number?
The funding opportunity number is W81XWH-14-NFRP-IIRA.
What award instrument types are associated with this opportunity?
The instrument types listed in the announcement include cooperative agreements and grants.
How much funding is estimated for this opportunity?
The total estimated funding amount in the announcement is $6,004,000.
How many awards are expected?
The announcement indicates an expectation of about seven awards.
Is cost sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications included in the full announcement.
What are the key dates for this posting?
The posting/creation date was May 27, 2014. The application closing date was July 24, 2014. The archive date was August 23, 2014.
How do applicants access the full announcement and apply?
Applications and program materials are routed through the electronic Biomedical Research Application Portal (eBRAP). The announcement also notes that applicants who have trouble accessing the full announcement online can contact the CDMRP Help Desk for assistance.
Where can applicants get help with eBRAP or access issues?
Applicants can contact the CDMRP Help Desk at 301-682-5507 or by email at help@eBRAP.org.
Where can applicants find additional resources related to human-subject research planning?
The opportunity points applicants to additional human-subject resources available through eBRAP, including information to clarify what is considered clinical research versus a clinical trial.
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| Funding Opportunity |
|---|
| DoD Neurofibromatosis New Investigator Award Apply for W81XWH 14 NFRP NIA Funding Number: W81XWH 14 NFRP NIA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Neurofibromatosis Clinial Trial Award Apply for W81XWH 14 NFRP CTA Funding Number: W81XWH 14 NFRP CTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Neurofibromatosis Exploration Hypothesis Development Award Apply for W81XWH 14 NFRP EHDA Funding Number: W81XWH 14 NFRP EHDA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Central Valley Project Conservation Program and Central Valley Project Improvement Act Habitat Restoration Program Apply for R14AS00050 Funding Number: R14AS00050 Agency: Bureau of Reclamation Category: Science and Technology and other Research and Development Funding Amount: $1,000,000 |
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| DoD Prostate Cancer Exploration Hypothesis Development Award Apply for W81XWH 14 PCRP EHDA Funding Number: W81XWH 14 PCRP EHDA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Laboratory Clinical Transition Award Apply for W81XWH 14 PCRP LCTA Funding Number: W81XWH 14 PCRP LCTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Postdoctoral Training Award Apply for W81XWH 14 PCRP PTA Funding Number: W81XWH 14 PCRP PTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Physician Research Training Award Apply for W81XWH 14 PCRP PRTA Funding Number: W81XWH 14 PCRP PRTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Dr. Barbara Terry Koroma Health Disparity Research Award Apply for W81XWH 14 PCRP HDRA Funding Number: W81XWH 14 PCRP HDRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Collaborative Undergraduate Historically Black Colleges and Universities Student Summer Training Program Award Apply for W81XWH 14 PCRP STPA Funding Number: W81XWH 14 PCRP STPA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Population Science Impact Award Apply for W81XWH 14 PCRP PSIA Funding Number: W81XWH 14 PCRP PSIA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Early Stage Innovations (ESI) Apply for NNH14ZOA001N 14ESI B2 Funding Number: NNH14ZOA001N 14ESI B2 Agency: NASA Headquarters Category: Science and Technology and other Research and Development Funding Amount: $500,000 |
| Tribal Colleges and Universities Program Apply for 14 572 Funding Number: 14 572 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: $2,500,000 |
| ADVANCE Increasing the Participation and Advancement of Women in Academic Science and Engineering Careers Apply for 14 573 Funding Number: 14 573 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: $4,000,000 |
| Cooperative Ecosystem Studies Unit, Great Basin Apply for G14AS00076 Funding Number: G14AS00076 Agency: Geological Survey Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Spinal Cord Injury Investigator Initiated Research Award Apply for W81XWH 14 SCIRP IIRA Funding Number: W81XWH 14 SCIRP IIRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Spinal Cord Injury Qualitative Research Award Apply for W81XWH 14 SCIRP QRA Funding Number: W81XWH 14 SCIRP QRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Spinal Cord Injury Translational Research Award Apply for W81XWH 14 SCIRP TRA Funding Number: W81XWH 14 SCIRP TRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Spinal Cord Injury Clinical Trial Award Apply for W81XWH 14 SCIRP CTA Funding Number: W81XWH 14 SCIRP CTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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