DoD Neurofibromatosis Investigator Initiated Research Award | Apply Online

Opportunity Summary:

The DoD Neurofibromatosis Investigator Initiated Research Award (IIRA) is a Department of Defense funding opportunity under the Neurofibromatosis Research Program (NFRP) designed to back investigator-driven projects that are both highly rigorous and likely to have a meaningful impact on neurofibromatosis (NF) research and, ultimately, patient care. The central goal is to support studies that can significantly advance understanding of NF biology, improve approaches to diagnosis or management, or help move promising concepts closer to real-world clinical benefit, while keeping the scientific bar high in terms of study design, execution, and reporting.

This award is intentionally broad in the kinds of research it will consider, as long as the work is clearly relevant to NF and positioned to make an important contribution. Projects can span essentially any stage of research (for example, basic mechanistic work, translational studies, or other non-trial human or population-based research), but clinical trials are explicitly excluded. The program also recognizes that strong research ideas can emerge from many sources, including laboratory discoveries, population-based observations, insights grounded in day-to-day clinical care, or even well-supported anecdotal observations that point to a testable hypothesis. A key requirement, however, is that applications must include preliminary and/or published data that directly ties into NF and supports the feasibility and rationale of the proposed project. In practice, this means applicants need to demonstrate that the idea is not purely speculative and that there is a credible foundation suggesting the approach can work and is worth pursuing.

A major theme of the opportunity is reproducibility and transparent research practices, especially for preclinical work. Applicants are expected to adhere to established standards for rigorous study design and reporting that increase the reliability and translational value of results. The announcement specifically points to the principles described by Landis et al. (Nature, 2012) emphasizing elements such as randomization, blinding, appropriate sample size estimation, and clear data handling procedures. Even though these standards are often discussed in the context of animal or other preclinical studies, the underlying logic applies widely: reduce bias, pre-plan analyses where possible, ensure adequate statistical power, and document methods and outcomes in a way that other researchers can evaluate and reproduce.

For projects that involve animal models, the requirements become more concrete. Applicants must include an Animal Research Plan (listed as Attachment 8 in the application package) explaining how the study will meet these rigor standards. They are also encouraged to use the ARRIVE guidelines (Animal Research Reporting of In Vivo Experiments) when planning and later reporting animal research, to help ensure that essential methodological details are included and that the study is set up to yield interpretable, reproducible results. This emphasis signals that the program is not just funding interesting ideas, but is also prioritizing work that is designed from the start to withstand scrutiny and to better predict what may eventually translate to human benefit.

Administratively, this opportunity was posted May 6, 2015, by the Department of the Army through USAMRAA (U.S. Army Medical Research Acquisition Activity), under Funding Opportunity Number W81XWH-15-NFRP-IIRA. The funding instrument is listed as a cooperative agreement and/or grant, and it falls under the Science and Technology and other Research and Development category, with CFDA 12.420 (Military Medical Research and Development). The program anticipated making about 7 awards, with an estimated total funding level of $6,004,000, and it did not require cost sharing or matching funds. Eligibility is described as unrestricted, meaning it is open to any type of entity, subject to any additional eligibility language contained in the full announcement. The original and current closing date listed for this cycle was July 27, 2015, and the opportunity was archived August 26, 2015. For applicants who had trouble accessing the announcement, the contact listed was the CDMRP Help Desk at 301-682-5507.

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