Opportunity Information: Apply for W81XWH 10 NFRP IIRA
Apply for W81XWH 10 NFRP IIRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Investigator Initiated Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Feb 23, 2010 and posted on Feb 23, 2010.
- Applicants must submit their applications by May 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Neurofibromatosis Research Program (NFRP) Investigator Initiated Research Award (IIRA) is a Department of the Army funding opportunity (USAMRAA) that supports hypothesis-driven basic and clinically oriented research focused on neurofibromatosis (NF) and schwannomatosis. The intent is to back projects that meaningfully advance the field by improving understanding of disease development, driving substantial improvements in how these conditions are diagnosed and treated, and ultimately improving quality of life for people affected by NF and schwannomatosis. This mechanism has a long track record, first offered in FY1996, with 321 applications received historically and 92 recommended for funding, signaling a competitive program aimed at impactful work.
For FY2010, the program highlights several priority needs where proposals are particularly encouraged. One emphasis is on serious NF complications associated with high mortality, including neoplasms (tumors) and cerebrovascular abnormalities. Another is on complications that produce high morbidity, such as skeletal problems, learning deficits, hormone-related effects, and pain, reflecting day-to-day burdens that can be debilitating even when not immediately life-threatening. The announcement also encourages efforts to refine and standardize tools needed to run strong future clinical trials, including imaging techniques, molecular and cellular markers, and quality-of-life metrics. In addition, it promotes translational research, especially development or preclinical testing of therapeutic agents intended for NF treatment, supporting projects that move discoveries closer to practical interventions without crossing into prohibited trial activity.
A key boundary of this award is that studies involving human subjects are allowed, but clinical trials are not. The program uses a typical definition of a clinical trial: a prospective study in which an intervention (such as a drug, device, behavioral approach, or surgical procedure) is tested in human subjects for measurable outcomes. Investigators who want to run a clinical trial are directed to use a separate Clinical Trial Award mechanism instead. Applicants are also expected to include preliminary data generated by the principal investigator, their research team, or a collaborator, and that preliminary data must be relevant to NF and to the proposed project, reinforcing that proposals should be grounded in existing evidence and feasibility.
Collaboration is strongly encouraged, especially partnerships that bridge basic science and clinical research or connect academia with biotechnology and pharmaceutical industry expertise. The announcement describes an option for a “qualified collaborator†that can make an application eligible for a higher funding level, but only if the collaboration is truly integral. To qualify, the principal investigator must submit a Statement of Collaboration, and the collaborator must provide a letter describing their role. The collaboration must be essential in the sense that the work could not be accomplished without the collaborator’s unique contribution; simply providing tissue samples or patient access is explicitly not enough. The collaborator must be at least at the Assistant Professor level (or equivalent), must commit at least 10 percent level of effort, and that effort should be reflected in the project budget.
Administratively, this FY2010 opportunity was posted February 23, 2010, with an application deadline of May 20, 2010, and an estimated total funding pool of $3,000,000 for an expected three awards. The funding instrument is listed as a cooperative agreement and grant, categorized under science and technology and other research and development, with CFDA 12.420 (Military Medical Research and Development). Eligibility is described as unrestricted (open to any type of entity), with any caveats addressed in the full announcement text. For help accessing the announcement or submission systems, the notice provides contacts for program announcement assistance and the CDMRP eReceipt/Help Desk.
FAQs - DoD Neurofibromatosis Research Program (NFRP) Investigator Initiated Research Award (IIRA), FY2010
What is the NFRP Investigator Initiated Research Award (IIRA)?
The Neurofibromatosis Research Program (NFRP) Investigator Initiated Research Award (IIRA) is a Department of Defense funding opportunity (administered through the Department of the Army/USAMRAA) that supports hypothesis-driven basic research and clinically oriented research focused on neurofibromatosis (NF) and schwannomatosis.
What is the main purpose of this award?
The intent is to fund projects that meaningfully advance the NF and schwannomatosis field by improving understanding of disease development, driving substantial improvements in diagnosis and treatment, and ultimately improving quality of life for people affected by these conditions.
What kinds of research are supported under this mechanism?
The award supports hypothesis-driven research that can be basic (fundamental biology and mechanisms) or clinically oriented (research connected to clinical problems and patient impact) as long as it remains within the program rules, including the restriction that clinical trials are not allowed.
Which diseases or conditions must the research focus on?
Projects must be focused on neurofibromatosis (NF) and/or schwannomatosis, and the proposal is expected to be directly relevant to these conditions.
What priority research areas are highlighted for FY2010?
FY2010 encourages proposals in several priority areas, including: (1) serious NF complications associated with high mortality such as neoplasms (tumors) and cerebrovascular abnormalities; (2) complications associated with high morbidity such as skeletal problems, learning deficits, hormone-related effects, and pain; (3) refinement and standardization of tools needed for future clinical trials (for example imaging techniques, molecular/cellular markers, and quality-of-life metrics); and (4) translational research including development or preclinical testing of therapeutic agents intended for NF treatment.
Does the program allow studies with human subjects?
Yes. Studies involving human subjects are allowed under this award.
Are clinical trials allowed under the IIRA?
No. Clinical trials are not allowed under this award mechanism.
How does the program define a clinical trial?
The opportunity uses a typical definition: a clinical trial is a prospective study in which an intervention (such as a drug, device, behavioral approach, or surgical procedure) is tested in human subjects for measurable outcomes.
What should investigators do if they want to run a clinical trial?
Investigators who want to conduct a clinical trial are directed to apply under a separate Clinical Trial Award mechanism rather than the IIRA.
Is translational research encouraged, and what does that include here?
Yes. Translational research is encouraged, especially work involving development or preclinical testing of therapeutic agents intended for NF treatment. The emphasis is on moving discoveries closer to practical interventions while staying within the rule that clinical trials are not permitted under this mechanism.
Does the application require preliminary data?
Yes. Applicants are expected to include preliminary data.
Whose preliminary data can be used?
The preliminary data may be generated by the principal investigator, the PI's research team, or a collaborator.
What does the preliminary data need to show?
The preliminary data must be relevant to neurofibromatosis and to the proposed project, reflecting that the application should be grounded in evidence of feasibility and connection to NF/schwannomatosis.
Is collaboration encouraged?
Yes. Collaboration is strongly encouraged, especially collaborations that bridge basic science and clinical research or connect academic investigators with biotechnology or pharmaceutical industry expertise.
What is the "qualified collaborator" option mentioned in the announcement?
The announcement describes an option to include a "qualified collaborator" that can make an application eligible for a higher funding level, but only when the collaborator's contribution is truly integral to completing the proposed work.
What documentation is required to include a qualified collaborator?
The principal investigator must submit a Statement of Collaboration, and the collaborator must provide a letter describing their role in the project.
What makes a collaboration "integral" under this opportunity?
The collaboration must be essential, meaning the project could not be accomplished without the collaborator's unique contribution. The notice specifically states that simply providing tissue samples or patient access is not sufficient to qualify as an integral collaboration.
Are there requirements for the collaborator's position or experience level?
Yes. The collaborator must be at least at the Assistant Professor level (or equivalent).
Is there a minimum effort requirement for a qualified collaborator?
Yes. The collaborator must commit at least 10 percent level of effort, and that level of effort should be reflected in the project budget.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is open to any type of entity, with any additional caveats addressed in the full announcement text.
Which agency and program administer this opportunity?
This opportunity is a Department of the Army funding opportunity administered via USAMRAA under the DoD Neurofibromatosis Research Program (NFRP).
What funding instrument type is used?
The funding instrument is listed as a cooperative agreement and grant.
What is the CFDA number for this opportunity?
The CFDA is 12.420, Military Medical Research and Development.
When was this FY2010 opportunity posted, and what was the deadline?
The FY2010 opportunity was posted on February 23, 2010, and the application deadline was May 20, 2010.
How much funding was expected to be available in total for FY2010?
The estimated total funding pool for FY2010 was $3,000,000.
How many awards were expected?
The program estimated an expected three awards for FY2010.
How competitive is this award mechanism historically?
The mechanism has been offered since FY1996. Historically, 321 applications were received and 92 were recommended for funding, indicating a competitive program focused on impactful research.
What types of complications does the program especially encourage researchers to address?
For FY2010, the program encourages proposals that address serious, high-mortality complications (including neoplasms and cerebrovascular abnormalities) and high-morbidity complications that affect daily life (including skeletal problems, learning deficits, hormone-related effects, and pain).
Does the program encourage development of tools for future clinical trials?
Yes. The announcement encourages efforts to refine and standardize tools that support strong future clinical trials, including imaging techniques, molecular and cellular markers, and quality-of-life metrics.
Where can applicants get help with the announcement or submission systems?
The notice provides contacts for program announcement assistance and for the CDMRP eReceipt/Help Desk to support applicants with access to the announcement and submission systems.
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