DoD Neurofibromatosis Investigator Initiated Research Award | Apply Online

Opportunity Summary:

The DoD Neurofibromatosis Investigator Initiated Research Award (IIRA) is a Fiscal Year 2013 funding opportunity under the Department of Defense Neurofibromatosis Research Program (NFRP), managed by the U.S. Army Medical Research Acquisition Activity (USAMRAA). Its overarching goal is to reduce the clinical impact of neurofibromatosis (NF) by backing innovative, high-impact research that can shift the field in meaningful ways. The program is designed to stimulate new research directions, tackle issues that have been historically underexplored, and build a balanced research portfolio spanning NF1, NF2, and schwannomatosis. A major theme is encouraging multidisciplinary and multi-institutional collaboration so that teams can bring fresh perspectives and complementary expertise to complex NF problems. The opportunity also explicitly aims to help cultivate the next generation of NF investigators and to support translational and clinical work that can move promising concepts from the lab into real-world patient care.

Research proposals are particularly encouraged if they align with one or more specific Areas of Emphasis reflecting critical needs in the NF community. These emphasis areas include cognitive and social dysfunction associated with NF, which covers neurodevelopmental and behavioral challenges that can substantially affect daily functioning and long-term outcomes. Another priority is drug discovery for NF, highlighting interest in identifying and advancing therapeutic candidates rather than limiting work to descriptive studies. The program also calls for work on the heterogeneity of neurofibromas and other NF-related tumors using modern biology approaches such as genomics, epigenetics, and systems biology, recognizing that tumor variability is a major barrier to predicting disease course and choosing effective treatments. Additional emphasis areas include manifestations of NF after adolescence, a topic that can be neglected when research focuses heavily on pediatric presentation; novel disease markers, including imaging-based markers and proteomics, intended to improve diagnosis, monitoring, and treatment response assessment; and pain in the context of NF, acknowledging pain as a significant and sometimes under-addressed driver of reduced quality of life.

In terms of what the award is meant to fund, the Investigator Initiated Research Award supports both basic science and clinically oriented research, as long as the work is innovative and clearly positioned to matter for patients. Proposed projects should aim to provide insight into how NF develops or into the mechanisms behind specific lesions or abnormalities caused by NF. Projects are also expected to point toward substantial improvement over current approaches to diagnosing and treating NF, rather than incremental advances with limited clinical relevance. A key expectation is tangible impact on the quality of life of people living with NF, which places weight on outcomes that matter to patients and families, such as better symptom control, improved functional abilities, earlier detection of complications, or more effective and less toxic treatments.

A practical requirement for applicants is that proposals must include preliminary data or published data relevant to NF and to the proposed research plan. This signals that, while innovation is strongly valued, the program also expects a credible foundation demonstrating feasibility and a clear connection to NF biology, NF-related tumors, or NF patient needs.

From an administrative standpoint, this opportunity was listed under Funding Opportunity Number W81XWH-13-NFRP-IIRA and offered support through grants or cooperative agreements within the Science and Technology/Research and Development category. The estimated total funding was $3.68 million, with an expectation of making about four awards, and there was no cost-sharing or matching requirement. Eligibility was described as unrestricted (open to any entity type), subject to any additional eligibility clarifications in the full announcement. The posting date was May 3, 2013, and the application deadline was July 11, 2013, with the opportunity archived on August 10, 2013. For access issues or questions about the announcement, the listed point of contact was the CDMRP Help Desk at 301-682-5507.

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