DOD Neurofibromatosis New Investigator Award | Apply Online

Opportunity Summary:

The DOD Neurofibromatosis New Investigator Award (NIA) is a Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA) funding opportunity under the Neurofibromatosis Research Program (NFRP) designed to help promising independent investigators establish themselves or continue their transition into a stable, productive research career focused on neurofibromatosis (NF). First introduced in fiscal year 1999, the mechanism has historically been competitive: across the years cited in the announcement, 266 applications were received and 36 were recommended for funding. The overall goal is to grow the pipeline of investigators working on NF and to encourage strong, impactful projects that respond to pressing needs in the NF community.

A key feature of this award is that prior experience in NF research is allowed but not required, which makes it especially relevant to early-stage investigators coming from adjacent fields (for example, cancer biology, neuroscience, genetics, vascular biology, imaging, pain research, or endocrinology) who can bring new ideas and tools into NF. At the same time, the program recognizes that newcomers may need disease-specific guidance, so applicants with limited NF background are strongly encouraged to include a collaborator who has established expertise in NF. Another central requirement is that proposals must include preliminary data that is relevant to NF and to the proposed project, and that data may come from the principal investigator, the research team, or a collaborator. In practical terms, the award is not meant for purely speculative concepts; it expects some evidence of feasibility or rationale that directly connects to NF.

For FY09, the announcement highlights several encouraged research areas aligned with critical unmet needs. One priority is complications of NF associated with high mortality, including neoplasms (tumors) and cerebrovascular abnormalities. Another is complications associated with high morbidity, such as skeletal problems, learning deficits, hormone-associated effects, and pain, reflecting a focus on issues that substantially affect day-to-day function and long-term quality of life. The program also encourages refinement and standardization work that can strengthen future clinical trials, such as improving imaging techniques and establishing molecular and cellular markers, along with quality-of-life metrics that can be used consistently across studies and sites. Finally, the award emphasizes translational research, including development or preclinical testing of therapeutic agents intended to treat NF, supporting the step between basic discovery and eventual clinical application.

This opportunity supports research and development activities (Science and Technology and other R&D) and offers funding through either a cooperative agreement or a grant. The opportunity does not require cost sharing or matching. The estimated total funding listed is $1,200,000, with an expectation of making 2 awards, indicating a relatively small number of funded projects and, therefore, a selective review environment. Eligibility is described as unrestricted (open to any entity type), subject to any clarifications contained in the full announcement, so applicants typically need to verify specific eligibility rules in the program announcement section referenced (including the PI eligibility requirements noted as being in Section I.C.).

A major boundary condition is that clinical trials are not permitted under this mechanism. Applicants who want to run a clinical trial are directed to a separate Clinical Trial Award mechanism within the program. This distinction signals that the New Investigator Award is intended for foundational, mechanistic, tool-building, or preclinical therapeutic work that can position projects for later-stage clinical testing rather than executing clinical trials themselves.

Administratively, the funding opportunity number is W81XWH 09 NFRP NIA, and it is associated with CFDA 12.420 (Military Medical Research and Development). The opportunity was posted on February 2, 2009, with an original and current closing date of April 14, 2009, and an archive date of May 14, 2009. For applicants needing assistance accessing the full announcement or navigating submission systems, the notice provides program announcement help and eReceipt/CDMRP helpdesk contact points, reflecting that the program is administered through the CDMRP infrastructure.

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