Opportunity Information: Apply for W81XWH 10 NFRP PTA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Postdoctoral Traineeship Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Mar 2, 2010 and posted on Mar 2, 2010.
  • Applicants must submit their applications by May 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $600,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 4 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 10 NFRP PTA

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Opportunity Summary:

The DoD Neurofibromatosis Postdoctoral Traineeship Award (Funding Opportunity Number W81XWH-10-NFRP-PTA) is a Department of the Army/USAMRAA funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) Neurofibromatosis Research Program (NFRP). It is a discretionary research and training award intended to support postdoctoral-level scientists and clinicians who are early in their careers and want to build the experience, skills, and track record needed to become independent investigators focused on neurofibromatosis (NF). The mechanism was introduced in FY09, and the program notes that, up to that point, a small number of applications had been received and about half had been recommended for funding, signaling a selective but real pathway for strong candidates.

A defining feature of this traineeship is that the postdoctoral trainee is treated as the Principal Investigator (PI). That means the trainee is expected to take primary responsibility for shaping and writing the project narrative, while still working with guidance and oversight from an experienced mentor. The review emphasis is less about funding a large, established lab and more about investing in the individual trainee, the quality and commitment of the mentor, and the strength of the overall training plan and research environment. In practice, the award is designed to function as a career-development bridge: it supports a focused NF research project while also strengthening the trainee's independence through a structured mentorship and training experience.

The award primarily provides salary support for the PI (the postdoctoral trainee), and it requires active involvement from a designated mentor who is already established in NF research. The mentor is expected to demonstrate credibility through a record of NF-related funding and publications, reinforcing that the trainee will be embedded in a setting capable of providing high-quality scientific direction, resources, and professional development. Importantly, the trainee does not have to come into the program with prior NF research experience, but the proposed work itself must be clearly centered on NF. Applicants are therefore positioned to pivot into the NF field, provided they can justify their approach, training needs, and long-term commitment to NF research.

For FY10, the program highlights specific "areas of encouragement" that reflect pressing needs in the NF community. These priorities include work on serious complications associated with high mortality, such as NF-related neoplasms and cerebrovascular abnormalities, as well as complications associated with high morbidity, including skeletal problems, learning deficits, hormone-associated effects, and pain. The announcement also encourages proposals that refine and standardize tools needed for future clinical trials, such as imaging techniques, molecular and cellular markers, and quality-of-life metrics. In addition, it explicitly welcomes translational research aimed at developing or preclinically testing therapeutic agents for NF, signaling interest in projects that can move beyond basic discovery toward tangible interventions.

Administratively, the opportunity uses grant and cooperative agreement instruments within the Science and Technology/Research and Development category and falls under CFDA 12.420 (Military Medical Research and Development). The total estimated funding listed is $600,000 with an expectation of making about 4 awards, and there is no cost sharing or matching requirement. Eligibility is described as unrestricted (open broadly to applicant organizations, subject to any clarifications in the full announcement). The posting date is March 2, 2010, with an original and current closing date of May 20, 2010, and an archive date of June 19, 2010. For support, the announcement provides contact points for help accessing the announcement and for electronic submission assistance through the CDMRP help resources.

FAQs: DoD Neurofibromatosis Postdoctoral Traineeship Award (W81XWH-10-NFRP-PTA)

What is the DoD Neurofibromatosis Postdoctoral Traineeship Award?

The DoD Neurofibromatosis Postdoctoral Traineeship Award (Funding Opportunity Number W81XWH-10-NFRP-PTA) is a discretionary research and training award under the Congressionally Directed Medical Research Programs (CDMRP) Neurofibromatosis Research Program (NFRP), administered by the Department of the Army/USAMRAA. It is intended to support postdoctoral-level scientists and clinicians who are early in their careers and aiming to build the experience, skills, and track record needed to become independent investigators focused on neurofibromatosis (NF).

Who is this award designed to support?

This mechanism is designed for postdoctoral-level trainees (scientists and clinicians) who are early in their careers and want a structured bridge toward independence as NF-focused investigators.

Is this award more focused on the research project or the trainee?

The review emphasis is less about funding a large, established lab and more about investing in the individual trainee, the quality and commitment of the mentor, and the strength of the training plan and research environment. The award supports an NF-focused research project while strengthening the trainee's independence through structured mentorship and training.

Is the postdoctoral trainee considered the Principal Investigator (PI)?

Yes. A defining feature of this traineeship is that the postdoctoral trainee is treated as the Principal Investigator (PI). The trainee is expected to take primary responsibility for shaping and writing the project narrative, while working with guidance and oversight from an experienced mentor.

What role does the mentor play in this traineeship?

The mentor is expected to be actively involved and provide guidance and oversight. The mentor should be established in NF research and is expected to demonstrate credibility through a record of NF-related funding and publications. This helps show the trainee will be working in an environment with strong scientific direction, resources, and professional development.

Does the trainee need prior neurofibromatosis (NF) research experience to apply?

No. The trainee does not have to come into the program with prior NF research experience. However, the proposed work must be clearly centered on NF, and applicants should justify their approach, training needs, and long-term commitment to NF research.

What types of research topics are encouraged for FY10?

For FY10, the program highlights areas of encouragement that reflect pressing needs in the NF community. These include serious complications with high mortality (such as NF-related neoplasms and cerebrovascular abnormalities) and complications with high morbidity (including skeletal problems, learning deficits, hormone-associated effects, and pain). The announcement also encourages work that refines and standardizes tools needed for future clinical trials and welcomes translational research aimed at developing or preclinically testing therapeutic agents for NF.

What NF complications associated with high mortality are mentioned as priorities?

The opportunity specifically calls out serious complications associated with high mortality, including NF-related neoplasms and cerebrovascular abnormalities.

What NF complications associated with high morbidity are mentioned as priorities?

The opportunity specifically calls out complications associated with high morbidity, including skeletal problems, learning deficits, hormone-associated effects, and pain.

Does the program encourage clinical-trial enabling work?

Yes. It encourages proposals that refine and standardize tools needed for future clinical trials, such as imaging techniques, molecular and cellular markers, and quality-of-life metrics.

Is translational research encouraged under this award?

Yes. The announcement explicitly welcomes translational research aimed at developing or preclinically testing therapeutic agents for NF, indicating interest in projects that can move beyond basic discovery toward tangible interventions.

What kind of support does the award primarily provide?

The award primarily provides salary support for the PI (the postdoctoral trainee). It also requires active involvement from a designated NF-established mentor and a strong training plan and research environment.

How much funding is available and how many awards are expected?

The total estimated funding listed is $600,000, with an expectation of making about 4 awards.

Is there a cost sharing or matching requirement?

No. The opportunity states there is no cost sharing or matching requirement.

What is the CFDA number associated with this opportunity?

This opportunity falls under CFDA 12.420 (Military Medical Research and Development).

What type of funding instruments are used?

The opportunity uses grant and cooperative agreement instruments within the Science and Technology/Research and Development category.

Who is eligible to apply?

Eligibility is described as unrestricted (open broadly to applicant organizations), subject to any clarifications provided in the full announcement.

When was the opportunity posted and when did it close?

The posting date is March 2, 2010. The original and current closing date is May 20, 2010. The archive date is June 19, 2010.

Is there any indication of how competitive the award is?

The mechanism was introduced in FY09, and the program notes that up to that point a small number of applications had been received and about half had been recommended for funding. This suggests a selective process but a realistic funding pathway for strong candidates.

Where can applicants get help with the announcement or electronic submission?

The opportunity provides contact points for help accessing the announcement and for electronic submission assistance through CDMRP help resources.

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