Opportunity Information: Apply for W81XWH 14 OPORP OPORA
Apply for W81XWH 14 OPORP OPORA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Orthotics and Prosthetics Outcomes Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Oct 6, 2014 and posted on Oct 6, 2014.
- Applicants must submit their applications by Jan 20, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $8,900,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Orthotics and Prosthetics Outcomes Research Award (OPORA) is a Department of Defense funding opportunity first introduced in FY2014 under the Orthotics and Prosthetics Outcomes Research Program. It supports clinically focused research aimed at figuring out which prosthetic, orthotic, and rehabilitation approaches work best for Service Members and Veterans who have experienced traumatic extremity injury, limb salvage, or limb amputation. The central purpose is comparative effectiveness and outcomes: generating real-world evidence on functional results, patient-centered outcomes, and measurable impacts on patient care, with the longer-term intent of improving prescribing decisions, rehabilitation plans, secondary complication prevention, and policy decisions that affect this population.
Projects are expected to produce outcomes data directly tied to orthotic and prosthetic devices and/or related clinical and rehabilitation interventions, and applicants must clearly describe how the findings would affect patient care metrics. The announcement emphasizes practical usefulness, such as informing new clinical practice guidelines, improving prescription algorithms for device selection, and strengthening the evidence base clinicians and caregivers rely on. It also highlights broader outcomes beyond gait or mobility alone, including quality of life, community reintegration, and return to duty or return to work for individuals using prosthetic or orthotic devices due to limb trauma.
The program encourages collaboration with military clinicians and researchers and explicitly welcomes joint DoD and VA studies, including longitudinal work that follows patients over time. The kinds of studies the program is looking for include comparisons of different care pathways and interventions, with strong patient-centric outcome assessment. Examples of appropriate topics include identifying the best timing for prosthetic or orthotic interventions during treatment, testing different treatment algorithms to match patients with the most appropriate device, evaluating how specific devices influence maximum functional ability, and developing or validating outcomes related to preventing secondary harms from device use such as falls, skin breakdown, balance loss, or other adverse consequences. The scope also includes improving existing materials and techniques, as well as developing and assessing new materials and technologies that could lead to better comfort, durability, function, and overall health outcomes. In addition, studies can focus on rehabilitation approaches intended to speed up or enhance functional recovery trajectories for prosthetic and orthotic users.
Beyond clinical performance, OPORA allows proposals that examine health care delivery and decision-making factors that shape outcomes in practice, including cost, accessibility, policy adoption, and patient preferences. Methodologically, the opportunity is broad as long as the work stays clinically oriented and human-focused. Acceptable study designs include surveys, retrospective analyses, simulation modeling, longitudinal and cross-sectional observational studies, case-control designs, qualitative research, and clinical trials. Animal studies are explicitly not permitted under this mechanism, reinforcing that the award is intended for patient-relevant outcomes and near-term clinical applicability.
Funding is structured into two levels based on project maturity and translational readiness, and it is up to the Principal Investigator to choose the level that matches the proposed work. Funding Level 1 is intended for research backed by preliminary data with strong potential to push meaningful clinical translation forward. Funding Level 2 targets advanced translational efforts positioned for near-term clinical investigation. Clinical research and clinical trials can be proposed under either level, and projects may range from small to large scale across stages such as efficacy work, comparative effectiveness studies, observational research, human-use research, and trials.
Administratively, this opportunity (Funding Opportunity Number W81XWH-14-OPORP-OPORA) was offered by the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), under CFDA 12.420 (Military Medical Research and Development). It anticipated approximately six awards with an estimated total funding of about $8.9 million, did not require cost sharing, and had unrestricted eligibility (open to many entity types, subject to any additional eligibility clarifications in the full text). The announcement was posted October 6, 2014, with an application deadline of January 20, 2015, and it was later archived on February 19, 2015.
FAQs: DoD Orthotics and Prosthetics Outcomes Research Award (OPORA)
What is the OPORA grant opportunity?
The DoD Orthotics and Prosthetics Outcomes Research Award (OPORA) is a Department of Defense funding opportunity under the Orthotics and Prosthetics Outcomes Research Program. It supports clinically focused research that determines which prosthetic, orthotic, and rehabilitation approaches work best for Service Members and Veterans affected by traumatic extremity injury, limb salvage, or limb amputation.
What is the main purpose of OPORA-funded research?
The central purpose is comparative effectiveness and outcomes research. OPORA aims to generate real-world evidence on functional results, patient-centered outcomes, and measurable impacts on patient care, with the long-term goal of improving prescribing decisions, rehabilitation planning, prevention of secondary complications, and policy decisions affecting this population.
Who is the intended patient population for studies under this award?
Studies are intended to benefit Service Members and Veterans who have experienced traumatic extremity injury, limb salvage, or limb amputation and who use (or may use) prosthetic and/or orthotic devices and related rehabilitation interventions.
What kinds of outcomes does OPORA emphasize?
OPORA emphasizes outcomes that are clinically meaningful and patient-centered, including functional results and measurable impacts on care. The announcement also highlights outcomes beyond gait or mobility alone, such as quality of life, community reintegration, and return to duty or return to work for people using prosthetic or orthotic devices due to limb trauma.
What does OPORA mean by “comparative effectiveness�
Within this opportunity, comparative effectiveness refers to comparing different devices, interventions, or care pathways to determine which approaches produce better outcomes in real-world clinical contexts for the target population.
Do proposed projects need to be tied to specific devices or interventions?
Yes. Projects are expected to produce outcomes data directly tied to orthotic and prosthetic devices and/or related clinical and rehabilitation interventions.
How should applicants describe the impact of their findings?
Applicants must clearly describe how findings would affect patient care metrics. The announcement stresses practical usefulness, such as informing clinical practice guidelines, improving prescription algorithms for device selection, and strengthening the evidence base clinicians and caregivers rely on.
What are examples of research topics that fit OPORA?
Examples described in the announcement include:
- Identifying the best timing for prosthetic or orthotic interventions during treatment
- Testing treatment algorithms to match patients with the most appropriate device
- Evaluating how specific devices influence maximum functional ability
- Developing or validating outcomes related to preventing secondary harms (for example: falls, skin breakdown, balance loss, or other adverse consequences)
- Improving existing materials and techniques
- Developing and assessing new materials and technologies to improve comfort, durability, function, and overall health outcomes
- Studying rehabilitation approaches intended to speed up or enhance functional recovery trajectories
Are rehabilitation approaches within scope, or is this only about devices?
Rehabilitation is explicitly within scope. OPORA supports studies of clinical and rehabilitation interventions related to prosthetic and orthotic use, including approaches intended to speed up or enhance functional recovery trajectories.
Does OPORA consider outcomes beyond clinical performance?
Yes. OPORA allows proposals that examine health care delivery and decision-making factors that shape outcomes in practice, including cost, accessibility, policy adoption, and patient preferences.
Is collaboration with military or VA partners encouraged?
Yes. The program encourages collaboration with military clinicians and researchers and explicitly welcomes joint DoD and VA studies.
Are longitudinal studies allowed?
Yes. The opportunity explicitly includes longitudinal work that follows patients over time.
What study designs are considered acceptable under OPORA?
The announcement is methodologically broad as long as the work remains clinically oriented and human-focused. Acceptable designs include surveys, retrospective analyses, simulation modeling, longitudinal and cross-sectional observational studies, case-control designs, qualitative research, and clinical trials.
Are clinical trials allowed under this award?
Yes. Clinical research and clinical trials may be proposed under either funding level.
Are animal studies permitted?
No. Animal studies are explicitly not permitted under this mechanism, reflecting the program’s emphasis on patient-relevant outcomes and near-term clinical applicability.
How is funding structured for OPORA?
Funding is structured into two levels based on project maturity and translational readiness. The Principal Investigator selects the level that best matches the proposed work.
What is Funding Level 1 intended for?
Funding Level 1 is intended for research backed by preliminary data with strong potential to meaningfully advance clinical translation.
What is Funding Level 2 intended for?
Funding Level 2 is intended for advanced translational efforts positioned for near-term clinical investigation.
Can projects be small or large in scope?
Yes. The announcement indicates projects may range from small to large scale and may span stages such as efficacy work, comparative effectiveness studies, observational research, human-use research, and trials.
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is W81XWH-14-OPORP-OPORA.
Which DoD organization offered this opportunity?
This opportunity was offered by the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA 12.420, Military Medical Research and Development.
How many awards and how much total funding were anticipated?
The announcement anticipated approximately six awards with an estimated total funding of about $8.9 million.
Was cost sharing required?
No. The announcement stated that cost sharing was not required.
Who was eligible to apply?
Eligibility was described as unrestricted (open to many entity types), subject to any additional eligibility clarifications in the full announcement text.
When was the announcement posted and when were applications due?
The announcement was posted on October 6, 2014, and the application deadline was January 20, 2015.
Is this funding opportunity still open?
No. The opportunity was archived on February 19, 2015.
What kinds of practical deliverables or uses does OPORA prioritize?
The announcement emphasizes practical usefulness in clinical settings, including informing new or improved clinical practice guidelines, improving prescription algorithms for device selection, strengthening evidence used by clinicians and caregivers, and supporting decisions that affect patient care and policy.
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