DoD Ovarian Cancer Clinical Translational Award | Apply Online

Opportunity Summary:

The Department of Defense (DoD), through the U.S. Army Medical Research Acquisition Activity (USAMRAA) and the Congressionally Directed Medical Research Programs (CDMRP) Ovarian Cancer Research Program (OCRP), offered the Ovarian Cancer Clinical Translational Award (CTA) under funding opportunity number W81XWH-15-OCRP-CTA. This opportunity was designed to move promising ovarian cancer research closer to patient impact by supporting translational work that targets high-impact ideas or clear unmet needs in ovarian cancer. In practice, that means projects should be positioned to bridge the gap between laboratory discoveries and clinically meaningful applications, with a strong emphasis on potential relevance to patient outcomes, diagnostics, prevention strategies, or therapeutic development pathways.

The CTA mechanism supported both preclinical and clinical research studies, but it explicitly did not support clinical trials. In other words, applicants could propose studies using clinical samples, clinical data, patient-derived models, or other clinically oriented methods, but could not request funds to run an interventional clinical trial under this mechanism. At the same time, the announcement made an important distinction: while new clinical trials were not allowable, the award could support research that is related to or associated with ongoing or completed clinical trials funded elsewhere. This allows investigators to leverage trial resources, biospecimens, correlative science opportunities, follow-on analyses, biomarker validation work, or translational extensions that build on trial infrastructure without paying for the trial itself.

A key requirement of this opportunity was preliminary data. Applicants needed to demonstrate an existing foundation for the proposed translational direction, suggesting the program expected projects to be more mature than early exploratory concepts and to have credible feasibility and rationale. This requirement typically signals that reviewers will be looking for evidence that the approach is workable, that early results support the central hypothesis, and that the project is realistically positioned to produce actionable translational deliverables within the performance period.

From an administrative and funding standpoint, the opportunity fell under the discretionary category and allowed for awards made as either cooperative agreements or grants, reflecting that some projects may involve more substantial programmatic involvement or coordination expectations from the funding agency. The activity category was Science and Technology and other Research and Development, and the CFDA listing was 12.420 (Military Medical Research and Development). Cost sharing or matching was not required, reducing barriers for institutions that may not have access to matching funds.

In terms of scale and competitiveness, the posting anticipated approximately three awards, with an estimated total funding amount of $1,440,000 across all awards. Eligibility was listed as unrestricted (open to any type of entity), subject to any additional eligibility language within the full announcement, which generally means a broad set of organizations (such as universities, nonprofits, small businesses, and other research entities) could apply as long as they met any specific requirements described in the detailed solicitation.

The opportunity was posted on March 23, 2015, with an application closing date of August 5, 2015, and it was archived on September 4, 2015. Applicants needing help accessing the full announcement were directed to the CDMRP eBRAP Help Desk at 301-682-5507 or help@eBRAP.org, which is the standard support channel for CDMRP electronic submission and registration issues.

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