Opportunity Information: Apply for HT9425 23 PRP IIRA
Apply for HT9425 23 PRP IIRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD, Parkinson's Investigator-Initiated Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Apr 27, 2023.
- Applicants must submit their applications by Aug 17, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The Department of Defense Parkinson's Research Program (PRP) Investigator-Initiated Research Award (IIRA) is a competitive funding opportunity designed to support ambitious, high-impact Parkinson's disease (PD) projects that can meaningfully advance the field. Managed through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), this mechanism is meant for studies that are both scientifically rigorous and multidisciplinary, encouraging teams to bring together expertise across areas like basic neuroscience, engineering, bioinformatics, population science, translational research, and clinical investigation. The award is structured to support the full research pipeline, meaning proposals can range from fundamental laboratory studies of disease mechanisms all the way through clinical research, including clinical trials when appropriate.
A central expectation of the IIRA is a strong research strategy backed by clear feasibility. Applicants are expected to show a deep and critical understanding of the neurodegenerative processes involved in Parkinson's disease and to propose experimental approaches that are well-justified and methodologically sound. The program allows for either novel strategies or approaches grounded in existing evidence, as long as the scientific rationale is convincing. Feasibility needs to be demonstrated through a well-defined research design, realistic methods, and a clear plan for achieving the project goals. Preliminary data are encouraged to strengthen confidence in the approach, but they are not strictly required; however, if preliminary data are provided and have not been published, they must come from the Principal Investigator's lab or the research team and must directly support the feasibility of the proposed work. For applicants proposing clinical trials, the opportunity specifically notes an added requirement: submission of a Clinical Strategy Statement (identified in the announcement as Attachment 8), signaling that trial design, operational planning, and clinical execution will receive focused scrutiny.
Impact is treated as a defining review theme. The proposal must make a strong case that it addresses an area of major importance in Parkinson's research and that the results could matter in practical terms for people living with PD. Applications are expected to spell out both short-term and long-term impact in a direct way, not leaving reviewers to infer significance. In other words, it is not enough for a study to be interesting or technically clever; it must be framed around why the work is consequential for the field and how it could ultimately benefit individuals affected by Parkinson's disease, whether through improved understanding of disease biology, better tools for diagnosis or monitoring, new therapeutic strategies, or improved clinical care pathways.
The opportunity also includes programmatic alignment requirements. Proposed research must address at least one of the two fiscal year 2023 PRP Focus Areas, meaning applicants need to ensure their aims explicitly map to the priorities defined for that funding year. Although the focus areas themselves are not listed in the provided text, the requirement implies that alignment with those priorities is not optional and must be clearly stated in the application narrative.
Eligibility for this opportunity is broadly open, described as "unrestricted," meaning many types of organizations can apply, subject to any clarifications in the full announcement. The funding instrument can be either a grant or a cooperative agreement, which typically indicates that some awards may involve substantial involvement from the funding agency depending on project needs and structure. The opportunity was posted under Funding Opportunity Number HT9425-23-PRP-IIRA, associated with CFDA 12.420, and was originally released on April 27, 2023 with an original closing date of August 17, 2023. The announcement anticipated approximately four awards. The listed award ceiling is shown as 0, which usually indicates that a fixed maximum was not specified in the summarized record and that applicants should refer to the full funding announcement for budget constraints, allowable costs, and any implicit caps.
Finally, the IIRA places clear responsibility on the Principal Investigator and team readiness. The application should demonstrate that the investigators have the right expertise and roles to execute the work successfully and contribute meaningfully to the PD research landscape. A specific commitment requirement is included: the PI must dedicate at least 15 percent of their full-time professional effort to the award during the project period, reinforcing that this mechanism is intended for projects where the PI is actively engaged rather than only providing high-level oversight.
Frequently Asked Questions (FAQs)
What is the Investigator-Initiated Research Award (IIRA) under the DoD Parkinson's Research Program?
The Investigator-Initiated Research Award (IIRA) is a competitive funding opportunity within the Department of Defense (DoD) Parkinson's Research Program (PRP) intended to support ambitious, high-impact Parkinson's disease (PD) research projects that can meaningfully advance the field.
Which government office manages this funding opportunity?
The opportunity is managed through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA).
What kinds of Parkinson's disease research projects are appropriate for this award?
The award is designed to support scientifically rigorous and multidisciplinary PD projects. Supported work can span the full research pipeline, from fundamental laboratory studies of disease mechanisms through translational and clinical research, including clinical trials when appropriate.
Does the IIRA encourage multidisciplinary teams?
Yes. The mechanism encourages multidisciplinary efforts that bring together expertise across areas such as basic neuroscience, engineering, bioinformatics, population science, translational research, and clinical investigation.
Is this award limited to early-stage (basic) research only?
No. The IIRA is structured to support the full research pipeline. Proposals may range from basic research on disease mechanisms to clinical research, including clinical trials when appropriate.
Are clinical trials allowed under this award?
Yes, clinical trials may be included when appropriate. However, clinical trial proposals have an added requirement: submission of a Clinical Strategy Statement (referred to as Attachment 8 in the announcement).
What is the Clinical Strategy Statement and when is it required?
The Clinical Strategy Statement (Attachment 8) is required for applications proposing clinical trials. It signals that trial design, operational planning, and clinical execution will receive focused scrutiny during review.
What are the key expectations for the research strategy?
A central expectation is a strong research strategy with clear feasibility. Applicants are expected to demonstrate a deep and critical understanding of the neurodegenerative processes involved in Parkinson's disease and propose well-justified, methodologically sound experimental approaches.
Does the IIRA require a novel approach, or can it be based on existing evidence?
Either is acceptable. The program allows for novel strategies or approaches grounded in existing evidence, as long as the scientific rationale is convincing.
How should feasibility be demonstrated in the application?
Feasibility should be demonstrated through a well-defined research design, realistic methods, and a clear plan for achieving the project goals.
Are preliminary data required?
Preliminary data are encouraged to strengthen confidence in the approach, but they are not strictly required.
If preliminary data are included, are there restrictions on what can be used?
Yes. If preliminary data are provided and have not been published, they must come from the Principal Investigator's lab or the research team and must directly support the feasibility of the proposed work.
How important is "impact" in the review of this award?
Impact is treated as a defining review theme. The proposal must make a strong case that it addresses an area of major importance in Parkinson's research and that the results could matter in practical terms for people living with PD.
What should applicants include when describing impact?
Applications are expected to clearly spell out both short-term and long-term impact, rather than leaving reviewers to infer significance. The work should be framed around why it is consequential for the field and how it could ultimately benefit individuals affected by PD.
What kinds of real-world benefits does the opportunity highlight?
The opportunity notes that impactful work could lead to improved understanding of disease biology, better tools for diagnosis or monitoring, new therapeutic strategies, or improved clinical care pathways for people living with Parkinson's disease.
Do projects need to align with specific PRP priorities?
Yes. Proposed research must address at least one of the two fiscal year 2023 PRP Focus Areas, and the application should explicitly map the project aims to those priorities.
Are the fiscal year 2023 PRP Focus Areas listed in the provided information?
No. The provided summary states that alignment with at least one of the two FY2023 PRP Focus Areas is required, but it does not list what those focus areas are.
Who is eligible to apply?
Eligibility is described as "unrestricted," meaning many types of organizations can apply, subject to any clarifications in the full announcement.
What types of funding instruments may be used for awards?
The funding instrument can be either a grant or a cooperative agreement.
What does it mean that the instrument could be a cooperative agreement?
The summary notes that a cooperative agreement can indicate substantial involvement from the funding agency depending on project needs and structure, as opposed to a standard grant.
What is the Funding Opportunity Number for this program?
The Funding Opportunity Number is HT9425-23-PRP-IIRA.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 12.420.
When was this opportunity originally released and when did it close?
The opportunity was originally released on April 27, 2023, and the original closing date was August 17, 2023.
How many awards were anticipated?
The announcement anticipated approximately four awards.
Is there a maximum award amount (ceiling) listed?
The summarized record shows an award ceiling of 0, which typically indicates that a fixed maximum was not specified in the summary and that applicants should refer to the full funding announcement for budget constraints, allowable costs, and any implicit caps.
What does the opportunity expect regarding the Principal Investigator's commitment and involvement?
The opportunity places clear responsibility on the Principal Investigator (PI) and emphasizes team readiness. It includes a specific commitment requirement: the PI must dedicate at least 15 percent of their full-time professional effort to the award during the project period, indicating the PI should be actively engaged rather than providing only high-level oversight.
What does the application need to show about the research team?
The application should demonstrate that the investigators have the right expertise and roles to execute the work successfully and to contribute meaningfully to the Parkinson's disease research landscape.
What is the overall goal of this funding mechanism?
The overall goal is to support ambitious, high-impact Parkinson's disease research that is scientifically rigorous, feasible, and positioned to advance the field in ways that can ultimately matter for people living with PD.
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| DOD, Orthotics and Prosthetics Outcomes Clinical Trial Award Apply for HT9425 23 OPORP CTA Funding Number: HT9425 23 OPORP CTA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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