Opportunity Information: Apply for W81XWH 14 PRCRP IA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Peer Reviewed Cancer Idea Award with Special Focus" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on May 28, 2014 and posted on Apr 22, 2014.
  • Applicants must submit their applications by Sep 17, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $8,160,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 17 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:

The DoD Peer Reviewed Cancer Idea Award with Special Focus (Funding Opportunity Number W81XWH-14-PRCRP-IA) is a Department of the Army, USAMRAA-administered funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) Peer Reviewed Cancer Research Program (PRCRP). It is designed to push forward bold, early-stage cancer research ideas that may be too new, too unconventional, or too risky for more traditional grant mechanisms, but that could have an outsized payoff if successful. The award mechanism emphasizes genuinely innovative concepts, including new theories, methods, and research paradigms, rather than cautious extensions of existing work.

A defining feature of this particular Idea Award is its "Special Focus" requirement. Applicants are expected to center their proposals on cancers tied to exposures, conditions, or circumstances that are unique to military service or that occur disproportionately among military beneficiaries (active duty service members, their families, and other eligible populations served by the Military Health System). In practical terms, proposals need to make a clear case for military relevance, showing how the work connects to the needs of the Military Health System and aligns with the mission of the Defense Health Program (DHP) and the FY14 PRCRP. The opportunity materials point applicants to background resources on the Military Health System and PRCRP priorities via health.mil and the CDMRP PRCRP website and reports.

The program is explicit about what it does not want to fund: a logical next step in an already established research project, or an incremental improvement built directly on published data. Reviewers are being asked to look for projects that challenge existing assumptions, reframe problems in novel ways, or introduce highly creative approaches. Even though the research is intended to be exploratory, the proposal still needs to be scientifically grounded, meaning it should include a well-formulated and testable hypothesis supported by a strong rationale and an appropriate study design.

Another major expectation is that preliminary data should not be a central feature of the application. In fact, inclusion of preliminary data is discouraged because this mechanism is meant for untested ideas. The intended output of the award is to generate robust preliminary data during the funded period, creating a credible foundation for larger follow-on studies aimed at understanding cancer initiation mechanisms, progression pathways, or other fundamental drivers that could ultimately inform patient care and treatment options. Because of this, the award is also not meant to subsidize ongoing work in the applicant's lab; substantial existing datasets or extensive supporting results generally run counter to the spirit of the mechanism, aside from minimal data or truly serendipitous findings.

From an administrative standpoint, the opportunity was posted April 22, 2014, with an original and current closing date of September 17, 2014. The total estimated funding listed is $8,160,000, with an expected 17 awards. The funding instrument type indicates grants and cooperative agreements, and the activity category is science and technology and other research and development. There is no cost sharing or matching requirement. Eligibility is described as unrestricted, meaning it is broadly open to different types of entities, subject to any additional eligibility details provided in the full announcement.

For applicant support, the opportunity lists the CDMRP Help Desk as the point of contact for access issues or submission assistance, reachable by phone at 301-682-5507 or by email at help@eBRAP.org.

Frequently Asked Questions (FAQs)

What is the name of this funding opportunity?

This opportunity is the DoD Peer Reviewed Cancer Idea Award with Special Focus under the Peer Reviewed Cancer Research Program (PRCRP).

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number is W81XWH-14-PRCRP-IA.

Which agency and program are offering this award?

The award is administered by the Department of the Army through USAMRAA under the Congressionally Directed Medical Research Programs (CDMRP), specifically within the Peer Reviewed Cancer Research Program (PRCRP).

What is the main purpose of the Idea Award?

The purpose is to advance bold, early-stage cancer research ideas that may be too new, unconventional, or risky for traditional funding mechanisms, but that could deliver an outsized payoff if successful.

What types of research ideas are encouraged?

Applications are expected to emphasize genuinely innovative concepts, including new theories, methods, or research paradigms. Reviewers are looking for projects that challenge existing assumptions, reframe problems in novel ways, or introduce highly creative approaches.

What does "Special Focus" mean for this Idea Award?

"Special Focus" means proposals are expected to center on cancers tied to exposures, conditions, or circumstances that are unique to military service or that occur disproportionately among military beneficiaries (such as active duty service members, their families, and other eligible populations served by the Military Health System).

How should an application demonstrate military relevance?

The proposal should make a clear case for military relevance by showing how the work connects to the needs of the Military Health System and aligns with the mission of the Defense Health Program (DHP) and the FY14 PRCRP.

Are there suggested resources for understanding the Military Health System and PRCRP priorities?

Applicants are pointed to background resources on the Military Health System and PRCRP priorities via health.mil and the CDMRP PRCRP website and reports.

What kinds of projects are explicitly not a good fit for this mechanism?

The program is explicit that it does not want to fund a logical next step in an already established research project or an incremental improvement built directly on published data.

Is the research expected to be scientifically grounded even if it is high-risk?

Yes. Even though the work is intended to be exploratory, the proposal still needs to be scientifically grounded. It should include a well-formulated, testable hypothesis supported by a strong rationale and an appropriate study design.

Is preliminary data required?

No. Preliminary data should not be a central feature of the application, and inclusion of preliminary data is discouraged because this mechanism is designed for untested ideas.

If preliminary data is discouraged, what is the expected output of the award?

The intended output is to generate robust preliminary data during the funded period. This is meant to provide a credible foundation for larger follow-on studies focused on areas such as cancer initiation mechanisms, progression pathways, or other fundamental drivers that could ultimately inform patient care and treatment options.

Can this award be used to support ongoing work in an applicant's lab?

This award is not intended to subsidize ongoing work. Substantial existing datasets or extensive supporting results generally run counter to the spirit of the mechanism, aside from minimal data or truly serendipitous findings.

When was this opportunity posted?

The opportunity was posted on April 22, 2014.

What is the application deadline?

The original and current closing date listed is September 17, 2014.

How much total funding is estimated for this opportunity?

The total estimated funding is $8,160,000.

How many awards are expected?

An estimated 17 awards are expected.

What funding instrument types are associated with this opportunity?

The funding instrument types indicated are grants and cooperative agreements.

What is the activity category for this funding opportunity?

The activity category is science and technology and other research and development.

Is cost sharing or matching required?

No. There is no cost sharing or matching requirement.

Who is eligible to apply?

Eligibility is described as unrestricted, meaning it is broadly open to different types of entities, subject to any additional eligibility details provided in the full announcement.

Who should applicants contact for submission help or access issues?

Applicants can contact the CDMRP Help Desk for access issues or submission assistance at 301-682-5507 or by email at help@eBRAP.org.

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Previous opportunity: DoD Peer Reviewed Cancer Career Development Award

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