DOD Peer Reviewed Cancer Research Program New Investigator Award | Apply Online

Opportunity Summary:

The DOD Peer Reviewed Cancer Research Program (PRCRP) New Investigator Award is a Department of the Army (USAMRAA) funding opportunity aimed at helping early-career researchers establish themselves as independent principal investigators while advancing cancer research that is directly tied to military-relevant exposures. The program is designed to support a career transition or continued development for promising new PIs who bring innovative, high-impact ideas or enabling technologies. A designated collaborator is strongly encouraged, reflecting the program's interest in mentorship, complementary expertise, and team-based science that can accelerate a new investigator's trajectory.

A key feature of this opportunity is its narrow scientific scope: proposed projects must focus on genetic cancer research in relation to exposures and environments that are unique to, or commonly experienced in, military life. The solicitation explicitly states that no other topic areas are allowed, and it also explicitly excludes breast, prostate, and ovarian cancer research. In other words, the science has to be both genetics-focused and tightly connected to military exposure contexts, while staying away from those three cancer areas regardless of approach.

From a proposal-readiness standpoint, preliminary data are not required, which can lower the barrier for newer investigators who are still building resources and datasets. Even so, applications must still present a well-formulated and testable hypothesis supported by a strong scientific rationale. The expectation is that the work is hypothesis-driven and scientifically rigorous, even if the applicant is proposing a newer concept, emerging technology, or an early-stage line of inquiry.

For FY09, applications are expected to align with at least one of four specified focus areas, and review scoring will consider how responsive the proposal is to these areas. The first focus area emphasizes identifying and characterizing changes in gene structure and/or gene expression that arise from exposures or stressful environments that may increase cancer risk, whether those hazards occur alone or in combination. The announcement gives examples of exposure categories relevant to military populations, including radiation (UV and other sources), biological agents, chemicals, physical and/or psychological stress, and other environmental conditions such as noise, heat, and altitude. The second focus area targets the biological pathways that drive carcinogenic mechanisms when those pathways are influenced by military exposures, pushing applicants toward mechanistic insights rather than only descriptive associations. The third focus area looks at transgenerational cancer risk, meaning research that examines whether military exposures can influence cancer risk in subsequent generations through genetic or related heritable mechanisms. The fourth focus area asks investigators to evaluate differences in genetic susceptibility to cancer among ethnic groups as those differences relate to military exposures, which may involve gene-environment interactions and population-level susceptibility questions.

Military relevance is not optional or implied; it must be clearly and explicitly explained by the applicant. Reviewers are instructed to expect a direct articulation of why the research matters to service members, veterans, or military communities in the context of specific exposures and conditions associated with military lifestyle or duties. Applicants are directed to consult the full program announcement for complete requirements and details.

Administratively, this is a discretionary funding opportunity offered as either a cooperative agreement or a grant under CFDA 12.420 (Military Medical Research and Development). The funding opportunity number is W81XWH-09-PRCRP-NIA, and the estimated total funding is $2,100,000 with an expected five awards. Cost sharing or matching is not required. Eligibility is listed as unrestricted (open to any type of entity), subject to any clarifications provided in the full announcement. The opportunity was posted June 24, 2009, with an application closing date of December 9, 2009, and an archive date of January 8, 2010. For assistance, the announcement provides contacts for the CDMRP program announcement help and eReceipt helpdesk.

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